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01 · Clinical integration · Cas de liaison · 01B.04 · Athérosclérose IV — cholestérol, dyslipidémies et Lp(a) · all pages
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01B.04 · Athérosclérose IV — cholestérol, dyslipidémies et Lp(a)

Atherosclerosis IV — cholesterol, dyslipidemias and Lp(a)

Atherosclerosis series · 54 pages

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1Title Slide
2Modern vs. Ancestral Cholesterol Levels3Framingham Risk Factors4Normal LDL-C at Birth5LDL-C as Causal Driver — Four Lines of Evidence6Cumulative LDL-C Exposure Over Time
7Definition and Lipid Triad8Primary vs. Secondary Causes
9Definition and Genetic Causes10LDL Receptor Pathway — Goldstein & Brown11Epidemiology — Most Frequent Rare Disease12Clinical Signs — Xanthomas and Arcus Cornealis13Case Report — ACS in 10-Year-Old with HoFH14Case Report — CT and Coronary Angiography15Global Prevalence by WHO Region16Under-Recognition in Cardiology Practice17Dutch Lipid Clinic Network Criteria18Cascade Screening — Family Pedigree19Cascade Screening — Management Algorithm
FH in Switzerland
20Prevalence in ACS Patients21Prognosis After ACS
Treatment
22Statin Benefit — Event-Free Survival23Early Treatment — Children vs. Parents24Cumulative LDL-C Burden and Age of Statin Start25Gram-Years of LDL-C and MI Threshold
26Screening Indications
27Lipoprotein Classes — Size and Density28Lp(a) Structure and Dual Pathogenicity29Lp(a) as Independent Genetic Risk Factor30Lp(a) Levels and CVD Risk Thresholds31Global Prevalence of Elevated Lp(a)32Lp(a) vs. LDL Atherogenicity — Mendelian Randomization33Lp(a) and Arterial Wall Inflammation34Pathophysiology — Thrombus at Plaque Rupture35Lifetime Risk of Major CV Events36Effect of Current Lipid Therapies on Lp(a)37Specific Lp(a)-Lowering Drugs in Trials38Lp(a) Risk Calculator — Input39Lp(a) Risk Calculator — Risk With Lp(a)40Lp(a) Risk Calculator — Offsetting Risk via LDL/BP412022 EAS Consensus Summary
42Cholesterol Content of Foods43Hidden Lipids Per Portion44Dietary Choices — Indicated vs. Contraindicated45Physical Activity and Cholesterol Metabolism46Sports and Calories Burned47Optimal Weight Loss — Diet Plus Exercise482020 WHO Physical Activity Guidelines49Sedentary Lifestyle — Stair-Use Intervention
50FH — Most Common Rare Disease, Underdiagnosed51Dutch Lipid Network Score for FH Diagnosis52FH as Poor Prognostic Factor After ACS53Lipid-Lowering Treatment Reduces CV Events in FH54Lp(a) — LDL-Like Genetic Risk Factor