05.14A · Cours 14 — Revues systématiques et méta-analyses

Course 14 — Systematic reviews and meta-analyses

Course and questions · 49 pages

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Systematic Reviews and Meta-Analyses

1Systematic Reviews and Meta-Analyses

Review of Last Session

2Review of Last Session 3Confounding Example

4Lecture Objectives

Solving a Clinical Question

5Information Sources Hierarchy 6Stroke Clinical Example 7PubMed Search Example 8Limitations of Quick Searching

Systematic Review Method

9Definition of Systematic Review 10Step 1 — PICO Criteria 11Step 2 — Search Strategy and Selection 12Steps 3–4 — Description and Synthesis 13PICO Applied to Stroke Example 14Study Selection Flow Chart 15Quality Assessment of Included Trials 16Raw Trial Results Data

Narrative Systematic Review

17Individual Study Evaluation 18Narrative Synthesis of Results

19Principle of Meta-Analysis 20Forest Plot Example 21Interpreting the Common Effect

Statistical Method

22Simpson's Paradox 23Averaging Study-Level Effects 24Weighted Average Formula 25Weighted Average Applied to Example

26Precision and Power Gain

Precision and Power Gain

27No Single Trial Significant, Pool Is 28CI Width, Trial Count, and Quality

29Statistical Test of Common Effect

Statistical Test of Common Effect

30Applied to Stroke Example

31Principle of Heterogeneity 32Causes of Heterogeneity 33Detecting Heterogeneity 34Heterogeneity in Stroke Example

Exploring Causes

35Subgroup Analysis and Meta-Regression 36Subgroup Analysis Example — Enoxaparin vs Heparin 37Subgroup Analysis — Primary vs Secondary PCI 38Meta-Regression Example

39Effect Measures by Outcome Type 40Mean Difference Example

41Value of Meta-Analyses

Bias in Meta-Analysis

42Selection Bias and Publication Bias 43Funnel Plot — Symmetric Case 44Funnel Plot — Asymmetric Case

45Good Review Checklist 46Key Messages — Review vs Meta-Analysis 47Key Messages — Advantages and Risks 48Evidence Hierarchy Pyramid

49Next Session Preview

05.14APage 1Systematic Reviews and Meta-Analyses

Cours 14 — Revues systématiques et méta-analyses page 1

05.14APage 2Systematic Reviews and Meta-AnalysesReview of Last Session

Cours 14 — Revues systématiques et méta-analyses page 2

05.14APage 3Systematic Reviews and Meta-AnalysesReview of Last SessionConfounding Example

Cours 14 — Revues systématiques et méta-analyses page 3

05.14APage 4Systematic Reviews and Meta-AnalysesLecture Objectives

Cours 14 — Revues systématiques et méta-analyses page 4

05.14APage 5Systematic Reviews and Meta-AnalysesSolving a Clinical QuestionInformation Sources Hierarchy

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05.14APage 6Systematic Reviews and Meta-AnalysesSolving a Clinical QuestionStroke Clinical Example

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05.14APage 7Systematic Reviews and Meta-AnalysesSolving a Clinical QuestionPubMed Search Example

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05.14APage 8Systematic Reviews and Meta-AnalysesSolving a Clinical QuestionLimitations of Quick Searching

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05.14APage 9Systematic Reviews and Meta-AnalysesSystematic Review MethodDefinition of Systematic Review

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05.14APage 10Systematic Reviews and Meta-AnalysesSystematic Review MethodStep 1 — PICO Criteria

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05.14APage 11Systematic Reviews and Meta-AnalysesSystematic Review MethodStep 2 — Search Strategy and Selection

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05.14APage 12Systematic Reviews and Meta-AnalysesSystematic Review MethodSteps 3–4 — Description and Synthesis

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05.14APage 13Systematic Reviews and Meta-AnalysesSystematic Review MethodPICO Applied to Stroke Example

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05.14APage 14Systematic Reviews and Meta-AnalysesSystematic Review MethodStudy Selection Flow Chart

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05.14APage 15Systematic Reviews and Meta-AnalysesSystematic Review MethodQuality Assessment of Included Trials

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05.14APage 16Systematic Reviews and Meta-AnalysesSystematic Review MethodRaw Trial Results Data

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05.14APage 17Systematic Reviews and Meta-AnalysesNarrative Systematic ReviewIndividual Study Evaluation

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05.14APage 18Systematic Reviews and Meta-AnalysesNarrative Systematic ReviewNarrative Synthesis of Results

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05.14APage 19Systematic Reviews and Meta-AnalysesMeta-AnalysisPrinciple of Meta-Analysis

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05.14APage 20Systematic Reviews and Meta-AnalysesMeta-AnalysisForest Plot Example

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05.14APage 21Systematic Reviews and Meta-AnalysesMeta-AnalysisInterpreting the Common Effect

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05.14APage 22Systematic Reviews and Meta-AnalysesMeta-AnalysisStatistical MethodSimpson's Paradox

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05.14APage 23Systematic Reviews and Meta-AnalysesMeta-AnalysisStatistical MethodAveraging Study-Level Effects

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05.14APage 24Systematic Reviews and Meta-AnalysesMeta-AnalysisStatistical MethodWeighted Average Formula

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05.14APage 25Systematic Reviews and Meta-AnalysesMeta-AnalysisStatistical MethodWeighted Average Applied to Example

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05.14APage 26Systematic Reviews and Meta-AnalysesMeta-AnalysisPrecision and Power Gain

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05.14APage 27Systematic Reviews and Meta-AnalysesMeta-AnalysisPrecision and Power GainNo Single Trial Significant, Pool Is

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05.14APage 28Systematic Reviews and Meta-AnalysesMeta-AnalysisPrecision and Power GainCI Width, Trial Count, and Quality

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05.14APage 29Systematic Reviews and Meta-AnalysesMeta-AnalysisStatistical Test of Common Effect

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05.14APage 30Systematic Reviews and Meta-AnalysesMeta-AnalysisStatistical Test of Common EffectApplied to Stroke Example

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05.14APage 31Systematic Reviews and Meta-AnalysesHeterogeneityPrinciple of Heterogeneity

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05.14APage 32Systematic Reviews and Meta-AnalysesHeterogeneityCauses of Heterogeneity

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05.14APage 33Systematic Reviews and Meta-AnalysesHeterogeneityDetecting Heterogeneity

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05.14APage 34Systematic Reviews and Meta-AnalysesHeterogeneityHeterogeneity in Stroke Example

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05.14APage 35Systematic Reviews and Meta-AnalysesHeterogeneityExploring CausesSubgroup Analysis and Meta-Regression

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05.14APage 36Systematic Reviews and Meta-AnalysesHeterogeneityExploring CausesSubgroup Analysis Example — Enoxaparin vs Heparin

Cours 14 — Revues systématiques et méta-analyses page 36

05.14APage 37Systematic Reviews and Meta-AnalysesHeterogeneityExploring CausesSubgroup Analysis — Primary vs Secondary PCI

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05.14APage 38Systematic Reviews and Meta-AnalysesHeterogeneityExploring CausesMeta-Regression Example

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05.14APage 39Systematic Reviews and Meta-AnalysesMeta-AnalysisEffect Measures by Outcome Type

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05.14APage 40Systematic Reviews and Meta-AnalysesMeta-AnalysisMean Difference Example

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05.14APage 41Systematic Reviews and Meta-AnalysesValue of Meta-Analyses

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05.14APage 42Systematic Reviews and Meta-AnalysesBias in Meta-AnalysisSelection Bias and Publication Bias

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05.14APage 43Systematic Reviews and Meta-AnalysesBias in Meta-AnalysisFunnel Plot — Symmetric Case

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05.14APage 44Systematic Reviews and Meta-AnalysesBias in Meta-AnalysisFunnel Plot — Asymmetric Case

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05.14APage 45Systematic Reviews and Meta-AnalysesSummaryGood Review Checklist

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05.14APage 46Systematic Reviews and Meta-AnalysesSummaryKey Messages — Review vs Meta-Analysis

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05.14APage 47Systematic Reviews and Meta-AnalysesSummaryKey Messages — Advantages and Risks

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05.14APage 48Systematic Reviews and Meta-AnalysesSummaryEvidence Hierarchy Pyramid

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05.14APage 49Systematic Reviews and Meta-AnalysesNext Session Preview

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