06A.04APage 1Title slide
06A.04A · Cours 4 — Génome et chromatine
Course 4 — Genome and chromatin
SMB1 De la molécule à la cellule De l'ADN à la protéine · 81 pages
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06A.04APage 2Part II overview
06A.04APage 3Course logistics
06A.04APage 4Slide icon guide
06A.04APage 5Lecture 4 outline
06A.04APage 6Section 1: The Genome
06A.04APage 7The GenomeCentral dogma recap
06A.04APage 8The GenomePhysical vs functional
06A.04APage 9The GenomeDNA double helix
06A.04APage 10The GenomeChromosome organization
06A.04APage 11The GenomeEukaryotic chromosome structure
06A.04APage 12The GenomeGenome in nucleus
06A.04APage 13The GenomeMitochondrial DNA
06A.04APage 14The GenomeDNA as cell fraction
06A.04APage 15The GenomeGenome size variation
06A.04APage 16The GenomeGenome size variation
06A.04APage 17The GenomePhysical vs functional (transition)
06A.04APage 18The GenomeGenome information roles
06A.04APage 19The GenomeGenes
06A.04APage 20The GenomeGenesExons and introns
06A.04APage 21The GenomeGenesVariable intron number/size
06A.04APage 22The GenomeGenome size vs gene count
06A.04APage 23The GenomeGenome size vs gene count
06A.04APage 24The GenomeGenome size vs gene count
06A.04APage 25The GenomeSize ≠ gene number
06A.04APage 26The GenomeIntron size between species
06A.04APage 27The GenomeNon-coding genomeCoding fraction (1.2%)
06A.04APage 28The GenomeNon-coding genomeStructural elements
06A.04APage 29The GenomeNon-coding genomeRegulatory sequences (2–3%)
06A.04APage 30The GenomeNon-coding genomeRepeated sequences (~60%)
06A.04APage 31The GenomeNon-coding genomeTransposable elements
06A.04APage 32The GenomeNon-coding genomeRole of repeated sequences
06A.04APage 33The GenomeNon-coding genomeRepeats across species
06A.04APage 34Quiz 1
06A.04APage 35Section 2: Genome Evolution
06A.04APage 36Genome EvolutionGene sharing model
06A.04APage 37Genome EvolutionGene sharing model
06A.04APage 38Genome EvolutionCommon vs specific genes
06A.04APage 39Genome EvolutionCommon vs specific genes
06A.04APage 40Genome EvolutionHuman common gene distribution
06A.04APage 41Genome EvolutionGenetic innovation mechanisms
06A.04APage 42Genome EvolutionBreak
06A.04APage 43Genome EvolutionIntragenic mutations
06A.04APage 44Genome EvolutionIntragenic mutationsPoint mutations
06A.04APage 46Genome EvolutionOrthologous genes
06A.04APage 48Genome EvolutionGene duplication
06A.04APage 49Genome EvolutionGene duplicationUnequal crossing over
06A.04APage 50Genome EvolutionParalogous genes
06A.04APage 51Genome EvolutionPseudogenes
06A.04APage 52Genome EvolutionGene duplication fates
06A.04APage 53Genome EvolutionGene familiesGlobin gene family
06A.04APage 54Genome EvolutionGene families
06A.04APage 55Genome EvolutionHomologous genes
06A.04APage 56Genome EvolutionExon shuffling
06A.04APage 57Genome EvolutionExon shufflingNon-allelic recombination
06A.04APage 59Genome EvolutionExon shufflingtPA mosaic gene
06A.04APage 60Quiz 2
06A.04APage 61Section 3: 3D Genome Organization
06A.04APage 623D Genome OrganizationGenome in nucleus
06A.04APage 633D Genome OrganizationDNA packing problem
06A.04APage 643D Genome OrganizationChromatin
06A.04APage 653D Genome OrganizationChromatin levels
06A.04APage 663D Genome OrganizationNucleosome
06A.04APage 673D Genome OrganizationNucleosome146 bp, histone octamer
06A.04APage 683D Genome OrganizationNucleosomeAssembly steps
06A.04APage 703D Genome Organization30 nm fiber
06A.04APage 713D Genome OrganizationChromatin loops
06A.04APage 723D Genome OrganizationHistone modificationsHistone tails
06A.04APage 743D Genome OrganizationChromatin dynamics
06A.04APage 753D Genome OrganizationHeterochromatin
06A.04APage 763D Genome OrganizationEuchromatin vs heterochromatin
06A.04APage 773D Genome OrganizationChromatin summary
06A.04APage 783D Genome OrganizationChromosome territories
06A.04APage 79Quiz 3
06A.04APage 80Course 4 objectives
06A.04APage 81Gene annotation exampleHuman X chromosome region
