06B.04A · Génétique humaine — session 4

Human genetics — session 4

SMB1 De la molécule à la cellule Génétique et génomique humaine · 38 pages

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Human genetics — session 4

Lecture Icon Guide

2Lecture Icon Guide

Live Participation

3Live Participation

Genome Variability Sources

5Central Question 6Ancestral Contributions 7De Novo Variants 8Meiotic Recombination 9Recombination Hotspots 10Haplotypes & LD Blocks 11Gametogenesis & Fertilization 12Successive Fertilizations 13Within-population Mixing 14Between-population Mixing 15Four Sources Summary

Population Genomics

16Geographic & Temporal Factors 17Variant Count by Ancestry

18Ancient DNA Research 19Out-of-Africa Migration

Environmental Adaptation

20Migration & New Environments 21Selection Marks in Genomes 22Lactase Persistence 23Neanderthal Admixture 24Neanderthal Immune Introgression 25FADS Dietary Adaptation 26Adaptation-Disease Trade-offs

Selection Mechanisms

27Selection Mechanisms 28Positive Selection 29Pre-existing Variant Selection 30Multi-variant Selection 31Balancing Selection 32Selection Types Summary

Evolution & Disease

33Variant Fates 34Ancestry from Neutral Variants 35Variant Outcomes Summary 36Modern Era Consequences 37Human Activity & Evolution

Learning Objectives

38Learning Objectives

06B.04APage 1Course Agenda

Génétique humaine — session 4 page 1

06B.04APage 2Lecture Icon Guide

Génétique humaine — session 4 page 2

06B.04APage 3Live Participation

Génétique humaine — session 4 page 3

06B.04APage 4Session Title

Génétique humaine — session 4 page 4

06B.04APage 5Genome Variability SourcesCentral Question

Génétique humaine — session 4 page 5

06B.04APage 6Genome Variability SourcesAncestral Contributions

Génétique humaine — session 4 page 6

06B.04APage 7Genome Variability SourcesDe Novo Variants

Génétique humaine — session 4 page 7

06B.04APage 8Genome Variability SourcesMeiotic Recombination

Génétique humaine — session 4 page 8

06B.04APage 9Genome Variability SourcesRecombination Hotspots

Génétique humaine — session 4 page 9

06B.04APage 10Genome Variability SourcesHaplotypes & LD Blocks

Génétique humaine — session 4 page 10

06B.04APage 11Genome Variability SourcesGametogenesis & Fertilization

Génétique humaine — session 4 page 11

06B.04APage 12Genome Variability SourcesSuccessive Fertilizations

Génétique humaine — session 4 page 12

06B.04APage 13Genome Variability SourcesWithin-population Mixing

Génétique humaine — session 4 page 13

06B.04APage 14Genome Variability SourcesBetween-population Mixing

Génétique humaine — session 4 page 14

06B.04APage 15Genome Variability SourcesFour Sources Summary

Génétique humaine — session 4 page 15

06B.04APage 16Population GenomicsGeographic & Temporal Factors

Génétique humaine — session 4 page 16

06B.04APage 17Population GenomicsVariant Count by Ancestry

Génétique humaine — session 4 page 17

06B.04APage 18PaleogeneticsAncient DNA Research

Génétique humaine — session 4 page 18

06B.04APage 19PaleogeneticsOut-of-Africa Migration

Génétique humaine — session 4 page 19

06B.04APage 20Environmental AdaptationMigration & New Environments

Génétique humaine — session 4 page 20

06B.04APage 21Environmental AdaptationSelection Marks in Genomes

Génétique humaine — session 4 page 21

06B.04APage 22Environmental AdaptationLactase Persistence

Génétique humaine — session 4 page 22

06B.04APage 23Environmental AdaptationNeanderthal Admixture

Génétique humaine — session 4 page 23

06B.04APage 24Environmental AdaptationNeanderthal Immune Introgression

Génétique humaine — session 4 page 24

06B.04APage 25Environmental AdaptationFADS Dietary Adaptation

Génétique humaine — session 4 page 25

06B.04APage 26Environmental AdaptationAdaptation-Disease Trade-offs

Génétique humaine — session 4 page 26

06B.04APage 27Selection Mechanisms

Génétique humaine — session 4 page 27

06B.04APage 28Selection MechanismsPositive Selection

Génétique humaine — session 4 page 28

06B.04APage 29Selection MechanismsPre-existing Variant Selection

Génétique humaine — session 4 page 29

06B.04APage 30Selection MechanismsMulti-variant Selection

Génétique humaine — session 4 page 30

06B.04APage 31Selection MechanismsBalancing Selection

Génétique humaine — session 4 page 31

06B.04APage 32Selection MechanismsSelection Types Summary

Génétique humaine — session 4 page 32

06B.04APage 33Evolution & DiseaseVariant Fates

Génétique humaine — session 4 page 33

06B.04APage 34Evolution & DiseaseAncestry from Neutral Variants

Génétique humaine — session 4 page 34

06B.04APage 35Evolution & DiseaseVariant Outcomes Summary

Génétique humaine — session 4 page 35

06B.04APage 36Evolution & DiseaseModern Era Consequences

Génétique humaine — session 4 page 36

06B.04APage 37Evolution & DiseaseHuman Activity & Evolution

Génétique humaine — session 4 page 37

06B.04APage 38Learning Objectives

Génétique humaine — session 4 page 38