07.03A · Les virus — diapositives

Viruses — slides

SMB1 De la molécule à la cellule Introduction à la microbiologie · 40 pages

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1Viruses 2Course outline

Viruses and their discovery

3Viruses and their discovery 4What is a virus?5Size and abundance of viruses 6Timeline of virus discovery 7Poll: detecting a non-bacterial agent 8Tobacco Mosaic Virus experiment 9Viruses are ubiquitous

Viruses influence our health

10Viruses influence our health 11First animal virus discovery 12Viral infections by body site 13Emerging and re-emerging viruses 14Prerequisites for productive infection 15Viral pathogenesis 16Viruses and cancer

Organization of viruses

17Organization of viruses 18Virion structure 19Viral genome 20Genes and proteins — SARS-CoV-2 21Minus/plus strand convention 22Baltimore classification 23Diversity of viral shapes

Evolutionary capacity of viruses

24Evolutionary capacity of viruses 25High mutation rate 26Selection of advantageous mutations 27Spike protein variants 28SARS-CoV-2 variant evolution in Geneva 29Contagiousness (R₀) vs mortality

The viral cycle

30The viral cycle 31Attachment and penetration 32Entry pathways 33Complete multiplication cycle 34Exit from host cell 35Blocking viral cycles — intro 36Poll: RNA(+) antivirals interchangeable?37SARS-CoV-2 cycle and antivirals 38HIV cycle and antivirals

39Learning objectives 40Closing

07.03APage 1Viruses

Les virus — diapositives page 1

07.03APage 2VirusesCourse outline

Les virus — diapositives page 2

07.03APage 3VirusesViruses and their discovery

Les virus — diapositives page 3

07.03APage 4VirusesViruses and their discoveryWhat is a virus?

Les virus — diapositives page 4

07.03APage 5VirusesViruses and their discoverySize and abundance of viruses

Les virus — diapositives page 5

07.03APage 6VirusesViruses and their discoveryTimeline of virus discovery

Les virus — diapositives page 6

07.03APage 7VirusesViruses and their discoveryPoll: detecting a non-bacterial agent

Les virus — diapositives page 7

07.03APage 8VirusesViruses and their discoveryTobacco Mosaic Virus experiment

Les virus — diapositives page 8

07.03APage 9VirusesViruses and their discoveryViruses are ubiquitous

Les virus — diapositives page 9

07.03APage 10VirusesViruses influence our health

Les virus — diapositives page 10

07.03APage 11VirusesViruses influence our healthFirst animal virus discovery

Les virus — diapositives page 11

07.03APage 12VirusesViruses influence our healthViral infections by body site

Les virus — diapositives page 12

07.03APage 13VirusesViruses influence our healthEmerging and re-emerging viruses

Les virus — diapositives page 13

07.03APage 14VirusesViruses influence our healthPrerequisites for productive infection

Les virus — diapositives page 14

07.03APage 15VirusesViruses influence our healthViral pathogenesis

Les virus — diapositives page 15

07.03APage 16VirusesViruses influence our healthViruses and cancer

Les virus — diapositives page 16

07.03APage 17VirusesOrganization of viruses

Les virus — diapositives page 17

07.03APage 18VirusesOrganization of virusesVirion structure

Les virus — diapositives page 18

07.03APage 19VirusesOrganization of virusesViral genome

Les virus — diapositives page 19

07.03APage 20VirusesOrganization of virusesGenes and proteins — SARS-CoV-2

Les virus — diapositives page 20

07.03APage 21VirusesOrganization of virusesMinus/plus strand convention

Les virus — diapositives page 21

07.03APage 22VirusesOrganization of virusesBaltimore classification

Les virus — diapositives page 22

07.03APage 23VirusesOrganization of virusesDiversity of viral shapes

Les virus — diapositives page 23

07.03APage 24VirusesEvolutionary capacity of viruses

Les virus — diapositives page 24

07.03APage 25VirusesEvolutionary capacity of virusesHigh mutation rate

Les virus — diapositives page 25

07.03APage 26VirusesEvolutionary capacity of virusesSelection of advantageous mutations

Les virus — diapositives page 26

07.03APage 27VirusesEvolutionary capacity of virusesSpike protein variants

Les virus — diapositives page 27

07.03APage 28VirusesEvolutionary capacity of virusesSARS-CoV-2 variant evolution in Geneva

Les virus — diapositives page 28

07.03APage 29VirusesEvolutionary capacity of virusesContagiousness (R₀) vs mortality

Les virus — diapositives page 29

07.03APage 30VirusesThe viral cycle

Les virus — diapositives page 30

07.03APage 31VirusesThe viral cycleAttachment and penetration

Les virus — diapositives page 31

07.03APage 32VirusesThe viral cycleEntry pathways

Les virus — diapositives page 32

07.03APage 33VirusesThe viral cycleComplete multiplication cycle

Les virus — diapositives page 33

07.03APage 34VirusesThe viral cycleExit from host cell

Les virus — diapositives page 34

07.03APage 35VirusesThe viral cycleBlocking viral cycles — intro

Les virus — diapositives page 35

07.03APage 36VirusesThe viral cyclePoll: RNA(+) antivirals interchangeable?

Les virus — diapositives page 36

07.03APage 37VirusesThe viral cycleSARS-CoV-2 cycle and antivirals

Les virus — diapositives page 37

07.03APage 38VirusesThe viral cycleHIV cycle and antivirals

Les virus — diapositives page 38

07.03APage 39VirusesLearning objectives

Les virus — diapositives page 39

07.03APage 40VirusesClosing

Les virus — diapositives page 40