09A.07 · Adaptation métabolique

Metabolic adaptation

Biochimie et métabolisme · 47 pages

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Metabolic adaptation

Metabolic Adaptation

1Metabolic Adaptation

Course Overview

2Course Overview

3Lecture Agenda

Acetyl-CoA Sources

4Nutritional State Overview 5From Carbohydrates 6From Lipids 7From Proteins

Citric Acid Cycle

8Link to ETC 9ETC Complexes & ATP Synthesis 10Energy Yield (38 ATP)11Acetyl-CoA Origins Summary

12Overview 13Ketogenesis & Ketolysis

Citric Acid Cycle

14Anabolic Precursors

Hormonal Regulation

15Insulin & Glucagon 16Hypoglycemia Response 17Glycemic Index & Lipogenesis

Glucose Homeostasis

18Phases I–V (Ruderman & Cahill)

Hepatic Glucose Production

19Glycogenolysis & Gluconeogenesis 20Gluconeogenesis Substrates 21Cori Cycle

Gluconeogenesis

22Irreversible Glycolysis Steps 23Bypassing Glycolysis 24Glucose-6-Phosphatase

Tissue Metabolic Integration

25Organs Overview 26Fuel Consumption per Tissue 27Energy Stores 28Substrate Distribution 29Postprandial Distribution 30Glucose Sources: Phases Graph 31Postprandial Nutrient Routing

33Phosphorylation Control 34Adipose Tissue (Postprandial)35Contracting Muscle 36Resting Muscle

Fasting Adaptation

37Overnight Fasting Distribution 38Glucose Sources: Overnight Window 39Overnight Fasting Integration 40Prolonged Fasting Distribution 41Glucose Sources: Prolonged Fasting 42Prolonged Fasting Integration 43Body Energy Reserves 44Adaptation Phases 45Fasting Weight Loss Rate 46Minnesota Starvation Study 47Refeeding Endocrine Changes

09A.07Page 1Metabolic Adaptation

Adaptation métabolique page 1

09A.07Page 2Course Overview

Adaptation métabolique page 2

09A.07Page 3Lecture Agenda

Adaptation métabolique page 3

09A.07Page 4Acetyl-CoA SourcesNutritional State Overview

Adaptation métabolique page 4

09A.07Page 5Acetyl-CoA SourcesFrom Carbohydrates

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09A.07Page 6Acetyl-CoA SourcesFrom Lipids

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09A.07Page 7Acetyl-CoA SourcesFrom Proteins

Adaptation métabolique page 7

09A.07Page 8Citric Acid CycleLink to ETC

Adaptation métabolique page 8

09A.07Page 9Citric Acid CycleETC Complexes & ATP Synthesis

Adaptation métabolique page 9

09A.07Page 10Citric Acid CycleEnergy Yield (38 ATP)

Adaptation métabolique page 10

09A.07Page 11Citric Acid CycleAcetyl-CoA Origins Summary

Adaptation métabolique page 11

09A.07Page 12Ketone BodiesOverview

Adaptation métabolique page 12

09A.07Page 13Ketone BodiesKetogenesis & Ketolysis

Adaptation métabolique page 13

09A.07Page 14Citric Acid CycleAnabolic Precursors

Adaptation métabolique page 14

09A.07Page 15Hormonal RegulationInsulin & Glucagon

Adaptation métabolique page 15

09A.07Page 16Hormonal RegulationHypoglycemia Response

Adaptation métabolique page 16

09A.07Page 17Hormonal RegulationGlycemic Index & Lipogenesis

Adaptation métabolique page 17

09A.07Page 18Glucose HomeostasisPhases I–V (Ruderman & Cahill)

Adaptation métabolique page 18

09A.07Page 19Hepatic Glucose ProductionGlycogenolysis & Gluconeogenesis

Adaptation métabolique page 19

09A.07Page 20Hepatic Glucose ProductionGluconeogenesis Substrates

Adaptation métabolique page 20

09A.07Page 21Hepatic Glucose ProductionCori Cycle

Adaptation métabolique page 21

09A.07Page 22GluconeogenesisIrreversible Glycolysis Steps

Adaptation métabolique page 22

09A.07Page 23GluconeogenesisBypassing Glycolysis

Adaptation métabolique page 23

09A.07Page 24GluconeogenesisGlucose-6-Phosphatase

Adaptation métabolique page 24

09A.07Page 25Tissue Metabolic IntegrationOrgans Overview

Adaptation métabolique page 25

09A.07Page 26Tissue Metabolic IntegrationFuel Consumption per Tissue

Adaptation métabolique page 26

09A.07Page 27Tissue Metabolic IntegrationEnergy Stores

Adaptation métabolique page 27

09A.07Page 28Tissue Metabolic IntegrationSubstrate Distribution

Adaptation métabolique page 28

09A.07Page 29Tissue Metabolic IntegrationPostprandial Distribution

Adaptation métabolique page 29

09A.07Page 30Tissue Metabolic IntegrationGlucose Sources: Phases Graph

Adaptation métabolique page 30

09A.07Page 31Tissue Metabolic IntegrationPostprandial Nutrient Routing

Adaptation métabolique page 31

09A.07Page 32Tissue Metabolic IntegrationPostprandial Nutrient Routing

Adaptation métabolique page 32

09A.07Page 33PDH RegulationPhosphorylation Control

Adaptation métabolique page 33

09A.07Page 34PDH RegulationAdipose Tissue (Postprandial)

Adaptation métabolique page 34

09A.07Page 35PDH RegulationContracting Muscle

Adaptation métabolique page 35

09A.07Page 36PDH RegulationResting Muscle

Adaptation métabolique page 36

09A.07Page 37Fasting AdaptationOvernight Fasting Distribution

Adaptation métabolique page 37

09A.07Page 38Fasting AdaptationGlucose Sources: Overnight Window

Adaptation métabolique page 38

09A.07Page 39Fasting AdaptationOvernight Fasting Integration

Adaptation métabolique page 39

09A.07Page 40Fasting AdaptationProlonged Fasting Distribution

Adaptation métabolique page 40

09A.07Page 41Fasting AdaptationGlucose Sources: Prolonged Fasting

Adaptation métabolique page 41

09A.07Page 42Fasting AdaptationProlonged Fasting Integration

Adaptation métabolique page 42

09A.07Page 43Fasting AdaptationBody Energy Reserves

Adaptation métabolique page 43

09A.07Page 44Fasting AdaptationAdaptation Phases

Adaptation métabolique page 44

09A.07Page 45Fasting AdaptationFasting Weight Loss Rate

Adaptation métabolique page 45

09A.07Page 46Fasting AdaptationMinnesota Starvation Study

Adaptation métabolique page 46

09A.07Page 47Fasting AdaptationRefeeding Endocrine Changes

Adaptation métabolique page 47