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09 · SMB2 · Cellule, tissus & développement · 09E.02 · Fécondation et empreinte génomique · all pages
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09E.02 · Fécondation et empreinte génomique

Fertilization and genomic imprinting

Mécanisme du développement · 92 pages

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Fertilization
1Fertilization
Lecture Overview
2Lecture Overview
Gametogenesis
3Somatic vs Germline Lineages4PGC Induction (Week 3)5Testis vs Ovary Timeline6Meiosis: Stages & Ploidy7Spermatogenesis vs Oogenesis
Spermatogenesis
8Testis Anatomy9Seminiferous Tubule Wall10Spermatogenesis Stages11Spermiogenesis12Spermatozoon Structure
Oogenesis
13Ovary Overview14Ovary Histology15Primordial & Primary Follicles16Secondary Follicle17Mature Follicle (Oocyte II)18Zona Pellucida & Corona Radiata19Zona Pellucida20Follicle Development Timeline21Hormonal Cycle (FSH/LH/Estrogen/Progesterone)22Corpus Luteum & Atretic Follicles23Ovulation24Stigma (Ovarian Rupture Point)25Oocyte I → Oocyte II (Asymmetric Division)26Ovum Structure (Oocyte II)27Oocyte II with Corona Radiata28Oocyte Transport to Ampulla
Fertilization
299-Step Overview30Step 1: Sperm Transport31Capacitation32Step 2: Oocyte Transport33Ovary → Tube → Uterus Route34Step 3: Acrosomal Reaction35Acrosomal Reaction Detail36Enzymatic Barrier Crossing37Corona Radiata & Zona Pellucida Layers38Step 4: Membrane Fusion → Zygote39IZUMO/CD9 Fusion & Oocyte Activation40Step 5: Cortical Reaction41Polyspermy Consequences42Steps 5–6: Polyspermy Block & Meiosis II43Recap 1: Corona & Zona Crossing44Recap 2: Membrane Fusion & Calcium Wave45Sperm-Oocyte Binding (IZUMO/JUNO)46Step 7: Male Pronucleus Formation47Human Zygote (1-Cell Embryo)48Zygote / Ootid (Mouse)49Step 8: Pronuclear Fusion & DNA Synthesis50Step 9: First Cleavage (2 Blastomeres)512-Blastomere Embryo (~24h)52In Vitro Fertilization (IVF)53ICSI
Non-Mendelian Genetics
54Intro: Mitochondrial Diseases & Imprinting
Fertilization
55Post-Fertilization Events Summary
Non-Mendelian Genetics
56Classical vs Non-Classical Genetics57Maternal Mitochondrial Inheritance58Nuclear Transfer (Prevent Mitochondrial Mutation)59Pronuclear Transfer & Spindle Transfer
Parental Genomic Imprinting
60Are Paternal & Maternal Genomes Equivalent?61Androgenote vs Gynogenote Results62Uniparental Embryo Development Failure63Hydatidiform Mole (Clinical)64Androgenotes: Partial & Complete Mole65Gynogenotes & Parthenogenesis66Parthenogenesis History (Bonnet/Aphids)67Automixis (Crocodile, 2023)68Imprinting Conclusion69Imprinting Pedigree Pattern70Paternal vs Maternal Allele Silencing71Promoter Methylation = Gene Silencing72DNA Methylation Mechanism73DNA & Histone Methylation74Histone Marks: Heterochromatin vs Euchromatin75Epigenetic Writers & Erasers76Gene Expression Control Levels77Methylation Profile Heritability78Methylation Dynamics: PGC → Gametogenesis → Implantation79DNMT3 (de novo) vs DNMT1 (Maintenance)80Imprinting Set in Gametogenesis; ZGA at 4-Cell81Zygotic Genome Activation (MZT)82Imprinting-Related Pathologies83Chr 15q12: Prader-Willi & Angelman Syndromes
Non-Mendelian Genetics
84Non-Mendelian Summary
Parental Genomic Imprinting
85Epigenetics Summary86Genomic Imprinting Summary87Imprinting Blocks Parthenogenesis (IGF2)
Gene and Society
88Gene and Society89Omics & Precision Medicine90Genetic Technologies: Ethical Issues91Personalized & Predictive Medicine92Gene and Society