10B.06 · Physiologie acido-basique

Acid-base physiology

Système respiratoire · 29 pages

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Acid-Base Physiology

1pH Across Body Compartments 2H+ in Solution and Origin of pH 3pH–[H+] Tables and Buffer Chemistry 4Mechanism of H+ Buffering

CO2/HCO3- Buffer System

5CO2 Hydration and Henderson-Hasselbalch 6Out-of-Equilibrium CO2/HCO3- Solutions 7Henderson-Hasselbalch Derivation 8Buffering Power: Closed vs Open Systems 9Buffering Power Curves: Single and Multiple Buffers 10Open-System CO2/HCO3- Buffering

CO2/HCO3- as Only Buffer

11Doubling PCO2: Respiratory Acidosis 12Four Major Acid-Base Disorders 13Metabolic Alkalosis and Acidosis 14Vomiting-Induced Metabolic Alkalosis 15Equivalence of Alkali-Loading Maneuvers

Davenport Diagram

16CO2 Isopleths and Buffer Lines 17Respiratory Disturbances on the Diagram 18Constructing the Non-HCO3- Buffer Line 19Metabolic Acidosis on the Diagram 20Metabolic Acid and Base Addition 21Quantitative Buffering: CO2 vs Non-HCO3-

Compensation of Acid-Base Disorders

22Metabolic Compensation for Respiratory Disorders 23Respiratory Compensation for Metabolic Disorders 24Summary: All Acid-Base States on Davenport

Intracellular pH Regulation

25Response to Intracellular Acid and Alkali Loads 26Acid Extruders vs Loaders: Steady State 27Catalog of Acid Extruders and Loaders 28Intracellular Response to Respiratory Acidosis

10B.06Page 1Acid-Base PhysiologypH and BufferspH Across Body Compartments

Physiologie acido-basique page 1

10B.06Page 2Acid-Base PhysiologypH and BuffersH+ in Solution and Origin of pH

Physiologie acido-basique page 2

10B.06Page 3Acid-Base PhysiologypH and BufferspH–[H+] Tables and Buffer Chemistry

Physiologie acido-basique page 3

10B.06Page 4Acid-Base PhysiologypH and BuffersMechanism of H+ Buffering

Physiologie acido-basique page 4

10B.06Page 5Acid-Base PhysiologyCO2/HCO3- Buffer SystemCO2 Hydration and Henderson-Hasselbalch

Physiologie acido-basique page 5

10B.06Page 6Acid-Base PhysiologyCO2/HCO3- Buffer SystemOut-of-Equilibrium CO2/HCO3- Solutions

Physiologie acido-basique page 6

10B.06Page 7Acid-Base PhysiologyCO2/HCO3- Buffer SystemHenderson-Hasselbalch Derivation

Physiologie acido-basique page 7

10B.06Page 8Acid-Base PhysiologyCO2/HCO3- Buffer SystemBuffering Power: Closed vs Open Systems

Physiologie acido-basique page 8

10B.06Page 9Acid-Base PhysiologyCO2/HCO3- Buffer SystemBuffering Power Curves: Single and Multiple Buffers

Physiologie acido-basique page 9

10B.06Page 10Acid-Base PhysiologyCO2/HCO3- Buffer SystemOpen-System CO2/HCO3- Buffering

Physiologie acido-basique page 10

10B.06Page 11Acid-Base PhysiologyCO2/HCO3- as Only BufferDoubling PCO2: Respiratory Acidosis

Physiologie acido-basique page 11

10B.06Page 12Acid-Base PhysiologyCO2/HCO3- as Only BufferFour Major Acid-Base Disorders

Physiologie acido-basique page 12

10B.06Page 13Acid-Base PhysiologyCO2/HCO3- as Only BufferMetabolic Alkalosis and Acidosis

Physiologie acido-basique page 13

10B.06Page 14Acid-Base PhysiologyCO2/HCO3- as Only BufferVomiting-Induced Metabolic Alkalosis

Physiologie acido-basique page 14

10B.06Page 15Acid-Base PhysiologyCO2/HCO3- as Only BufferEquivalence of Alkali-Loading Maneuvers

Physiologie acido-basique page 15

10B.06Page 16Acid-Base PhysiologyDavenport DiagramCO2 Isopleths and Buffer Lines

Physiologie acido-basique page 16

10B.06Page 17Acid-Base PhysiologyDavenport DiagramRespiratory Disturbances on the Diagram

Physiologie acido-basique page 17

10B.06Page 18Acid-Base PhysiologyDavenport DiagramConstructing the Non-HCO3- Buffer Line

Physiologie acido-basique page 18

10B.06Page 19Acid-Base PhysiologyDavenport DiagramMetabolic Acidosis on the Diagram

Physiologie acido-basique page 19

10B.06Page 20Acid-Base PhysiologyDavenport DiagramMetabolic Acid and Base Addition

Physiologie acido-basique page 20

10B.06Page 21Acid-Base PhysiologyDavenport DiagramQuantitative Buffering: CO2 vs Non-HCO3-

Physiologie acido-basique page 21

10B.06Page 22Acid-Base PhysiologyCompensation of Acid-Base DisordersMetabolic Compensation for Respiratory Disorders

Physiologie acido-basique page 22

10B.06Page 23Acid-Base PhysiologyCompensation of Acid-Base DisordersRespiratory Compensation for Metabolic Disorders

Physiologie acido-basique page 23

10B.06Page 24Acid-Base PhysiologyCompensation of Acid-Base DisordersSummary: All Acid-Base States on Davenport

Physiologie acido-basique page 24

10B.06Page 25Acid-Base PhysiologyIntracellular pH RegulationResponse to Intracellular Acid and Alkali Loads

Physiologie acido-basique page 25

10B.06Page 26Acid-Base PhysiologyIntracellular pH RegulationAcid Extruders vs Loaders: Steady State

Physiologie acido-basique page 26

10B.06Page 27Acid-Base PhysiologyIntracellular pH RegulationCatalog of Acid Extruders and Loaders

Physiologie acido-basique page 27

10B.06Page 28Acid-Base PhysiologyIntracellular pH RegulationIntracellular Response to Respiratory Acidosis

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10B.06Page 29Acid-Base PhysiologyReferences

Physiologie acido-basique page 29