10C.03 · Métabolisme de l’azote

Nitrogen metabolism

Système urinaire · 32 pages

All pagesPage view Open original PDF

All pages overview. Scroll the whole file, jump by section, or jump directly to a page.

← Previous file → Next file

Nitrogen Metabolism

1Nitrogen Metabolism 2Lecture Outline 3Forms of Nitrogen 4Nitrogen Cycle

Forms of Nitrogen

5Mineral vs Organic Recap 6Ammonia–Ammonium Equilibrium 7Amino Acid Structure

8NH3 Incorporation — Three Enzymes 9Mineral–Organic Nitrogen Cycle

Amino Nitrogen Metabolism

10Organ Overview Diagram

Amino Acid Catabolism

11Tissue Distribution 12Alanine & Glutamine as Carriers 13AA / α-Keto Acid Relationship 14Transamination Mechanism 15Catabolic Entry to Citric Acid Cycle 16AA Entry Points to TCA Cycle 17Key AA / α-Keto Acid Pairs 18ALAT and ASAT Transamination

Double Transamination

19Step 1 — Glutamate Intermediate 20Step 2 — Transfer to Alanine 21ALAT Reversibility 22Step 2 — Transfer to Aspartate 23ASAT Reversibility 24Summary — Alanine & Aspartate

Trans-deamination

25NH3 Release via GluDH 26Liver Urea vs Muscle Glutamine

Amino Acid Catabolism

27Double Deamination in Kidneys 28Intestinal Deamidation (Non-Exam)

29Muscle — BCAA to Alanine & Glutamine 30Intestine — Glutamine to NH3 & Alanine 31Liver — Alanine to Urea 32Kidney — Glutamine to Urinary NH4+

10C.03Page 1Nitrogen Metabolism

Métabolisme de l’azote page 1

10C.03Page 2Nitrogen MetabolismLecture Outline

Métabolisme de l’azote page 2

10C.03Page 3Nitrogen MetabolismForms of Nitrogen

Métabolisme de l’azote page 3

10C.03Page 4Nitrogen MetabolismNitrogen Cycle

Métabolisme de l’azote page 4

10C.03Page 5Nitrogen MetabolismForms of NitrogenMineral vs Organic Recap

Métabolisme de l’azote page 5

10C.03Page 6Nitrogen MetabolismForms of NitrogenAmmonia–Ammonium Equilibrium

Métabolisme de l’azote page 6

10C.03Page 7Nitrogen MetabolismForms of NitrogenAmino Acid Structure

Métabolisme de l’azote page 7

10C.03Page 8Nitrogen MetabolismNH3 Incorporation — Three Enzymes

Métabolisme de l’azote page 8

10C.03Page 9Nitrogen MetabolismMineral–Organic Nitrogen Cycle

Métabolisme de l’azote page 9

10C.03Page 10Nitrogen MetabolismAmino Nitrogen MetabolismOrgan Overview Diagram

Métabolisme de l’azote page 10

10C.03Page 11Nitrogen MetabolismAmino Acid CatabolismTissue Distribution

Métabolisme de l’azote page 11

10C.03Page 12Nitrogen MetabolismAmino Acid CatabolismAlanine & Glutamine as Carriers

Métabolisme de l’azote page 12

10C.03Page 13Nitrogen MetabolismAmino Acid CatabolismAA / α-Keto Acid Relationship

Métabolisme de l’azote page 13

10C.03Page 14Nitrogen MetabolismAmino Acid CatabolismTransamination Mechanism

Métabolisme de l’azote page 14

10C.03Page 15Nitrogen MetabolismAmino Acid CatabolismCatabolic Entry to Citric Acid Cycle

Métabolisme de l’azote page 15

10C.03Page 16Nitrogen MetabolismAmino Acid CatabolismAA Entry Points to TCA Cycle

Métabolisme de l’azote page 16

10C.03Page 17Nitrogen MetabolismAmino Acid CatabolismKey AA / α-Keto Acid Pairs

Métabolisme de l’azote page 17

10C.03Page 18Nitrogen MetabolismAmino Acid CatabolismALAT and ASAT Transamination

Métabolisme de l’azote page 18

10C.03Page 19Nitrogen MetabolismAmino Acid CatabolismDouble TransaminationStep 1 — Glutamate Intermediate

Métabolisme de l’azote page 19

10C.03Page 20Nitrogen MetabolismAmino Acid CatabolismDouble TransaminationStep 2 — Transfer to Alanine

Métabolisme de l’azote page 20

10C.03Page 21Nitrogen MetabolismAmino Acid CatabolismDouble TransaminationALAT Reversibility

Métabolisme de l’azote page 21

10C.03Page 22Nitrogen MetabolismAmino Acid CatabolismDouble TransaminationStep 2 — Transfer to Aspartate

Métabolisme de l’azote page 22

10C.03Page 23Nitrogen MetabolismAmino Acid CatabolismDouble TransaminationASAT Reversibility

Métabolisme de l’azote page 23

10C.03Page 24Nitrogen MetabolismAmino Acid CatabolismDouble TransaminationSummary — Alanine & Aspartate

Métabolisme de l’azote page 24

10C.03Page 25Nitrogen MetabolismAmino Acid CatabolismTrans-deaminationNH3 Release via GluDH

Métabolisme de l’azote page 25

10C.03Page 26Nitrogen MetabolismAmino Acid CatabolismTrans-deaminationLiver Urea vs Muscle Glutamine

Métabolisme de l’azote page 26

10C.03Page 27Nitrogen MetabolismAmino Acid CatabolismDouble Deamination in Kidneys

Métabolisme de l’azote page 27

10C.03Page 28Nitrogen MetabolismAmino Acid CatabolismIntestinal Deamidation (Non-Exam)

Métabolisme de l’azote page 28

10C.03Page 29Nitrogen MetabolismOrgan SummaryMuscle — BCAA to Alanine & Glutamine

Métabolisme de l’azote page 29

10C.03Page 30Nitrogen MetabolismOrgan SummaryIntestine — Glutamine to NH3 & Alanine

Métabolisme de l’azote page 30

10C.03Page 31Nitrogen MetabolismOrgan SummaryLiver — Alanine to Urea

Métabolisme de l’azote page 31

10C.03Page 32Nitrogen MetabolismOrgan SummaryKidney — Glutamine to Urinary NH4+

Métabolisme de l’azote page 32