11A.04 · Régulation de la glycémie

Glucose regulation

Système digestif · 62 pages

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Blood Glucose Regulation

1Blood Glucose Regulation 2Lecture Overview

Glucose Homeostasis

324h Glucose Profile 4Normal Glucose Range 5Diabetes Thresholds 6Inter-organ Glucose Dialogue

Glucose Sources & Utilization

7Production vs Utilization Balance 8Glucose Metabolic Pathways 9Muscle Glucose Use 10Brain Glucose Use 11RBC Glucose Use 12Adipose Glucose Use 13Liver Glucose Use

Nutritional States

14States Definition

Absorptive Phase

15Absorptive Phase 16Glucose & Insulin Daily Profile 17Meal Glucose Distribution 18Body Energy Reserves

Endocrine Pancreas

19Endocrine Pancreas 20Beta Cell: Glucose Sensor 21Insulin Secretion Regulation 22Beta Cell Secretion Mechanism

Absorptive Phase

23Insulin: Tissue-Specific Effects 24Main Absorptive Reactions 25Liver: Insulin Effects 26Muscle: Insulin Effects 27Adipose: Insulin Effects 28GLUT Transporters 29Insulin & GLUT4 Transport 30Organ Integration: Meal 31Meal Homeostasis Feedback 32Insulin Deficiency & Diabetes 33Type 1 Diabetes: History 34Type 1 Diabetes: Hyperglycemia

Post-Absorptive Phase

35Post-Absorptive Phase 36Timeline & Catabolism 37Overnight Glucose & Insulin 38Insulin/Glucagon Inverse Control 39Insulin vs Glucagon Table 40Glucagon Action 41Glucagon Liver Signaling 42Glucagon & Hepatic Glycogen 43Glucagon PKA Mechanism 44Glucagon: Summary 45Main Post-Absorptive Reactions 46Glucose Sources: Fasting Shift 47Fasting Pathways: Quantified 48Gluconeogenesis 49Lipolysis & Gluconeogenesis 50Organ Integration Diagram 51Fasting Metabolism Integration

Short & Prolonged Fasting

52Short & Prolonged Fasting 53Hormonal Adaptation Table 54Short Fast Glucose Sources 55Ketogenesis: Glucose Sparing 56Prolonged Fast Glucose Sources 57Fuel Shift: Day 3 vs Day 40 58Starvation Organ Integration

Counter-Regulatory Hormones

59Counter-Regulatory Hormones 60Hypoglycemia Response 61Adrenaline & Sympathetic Response 62Counter-Regulatory Summary

11A.04Page 1Blood Glucose Regulation

Régulation de la glycémie page 1

11A.04Page 2Blood Glucose RegulationLecture Overview

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11A.04Page 3Blood Glucose RegulationGlucose Homeostasis24h Glucose Profile

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11A.04Page 4Blood Glucose RegulationGlucose HomeostasisNormal Glucose Range

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11A.04Page 5Blood Glucose RegulationGlucose HomeostasisDiabetes Thresholds

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11A.04Page 6Blood Glucose RegulationGlucose HomeostasisInter-organ Glucose Dialogue

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11A.04Page 7Blood Glucose RegulationGlucose Sources & UtilizationProduction vs Utilization Balance

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11A.04Page 8Blood Glucose RegulationGlucose Sources & UtilizationGlucose Metabolic Pathways

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11A.04Page 9Blood Glucose RegulationGlucose Sources & UtilizationMuscle Glucose Use

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11A.04Page 10Blood Glucose RegulationGlucose Sources & UtilizationBrain Glucose Use

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11A.04Page 11Blood Glucose RegulationGlucose Sources & UtilizationRBC Glucose Use

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11A.04Page 12Blood Glucose RegulationGlucose Sources & UtilizationAdipose Glucose Use

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11A.04Page 13Blood Glucose RegulationGlucose Sources & UtilizationLiver Glucose Use

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11A.04Page 14Blood Glucose RegulationNutritional StatesStates Definition

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11A.04Page 15Blood Glucose RegulationAbsorptive Phase

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11A.04Page 16Blood Glucose RegulationAbsorptive PhaseGlucose & Insulin Daily Profile

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11A.04Page 17Blood Glucose RegulationAbsorptive PhaseMeal Glucose Distribution

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11A.04Page 18Blood Glucose RegulationAbsorptive PhaseBody Energy Reserves

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11A.04Page 19Blood Glucose RegulationEndocrine Pancreas

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11A.04Page 20Blood Glucose RegulationEndocrine PancreasBeta Cell: Glucose Sensor

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11A.04Page 21Blood Glucose RegulationEndocrine PancreasInsulin Secretion Regulation

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11A.04Page 22Blood Glucose RegulationEndocrine PancreasBeta Cell Secretion Mechanism

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11A.04Page 23Blood Glucose RegulationAbsorptive PhaseInsulin: Tissue-Specific Effects

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11A.04Page 24Blood Glucose RegulationAbsorptive PhaseMain Absorptive Reactions

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11A.04Page 25Blood Glucose RegulationAbsorptive PhaseLiver: Insulin Effects

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11A.04Page 26Blood Glucose RegulationAbsorptive PhaseMuscle: Insulin Effects

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11A.04Page 27Blood Glucose RegulationAbsorptive PhaseAdipose: Insulin Effects

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11A.04Page 28Blood Glucose RegulationAbsorptive PhaseGLUT Transporters

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11A.04Page 29Blood Glucose RegulationAbsorptive PhaseInsulin & GLUT4 Transport

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11A.04Page 30Blood Glucose RegulationAbsorptive PhaseOrgan Integration: Meal

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11A.04Page 31Blood Glucose RegulationAbsorptive PhaseMeal Homeostasis Feedback

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11A.04Page 32Blood Glucose RegulationAbsorptive PhaseInsulin Deficiency & Diabetes

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11A.04Page 33Blood Glucose RegulationAbsorptive PhaseType 1 Diabetes: History

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11A.04Page 34Blood Glucose RegulationAbsorptive PhaseType 1 Diabetes: Hyperglycemia

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11A.04Page 35Blood Glucose RegulationPost-Absorptive Phase

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11A.04Page 36Blood Glucose RegulationPost-Absorptive PhaseTimeline & Catabolism

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11A.04Page 37Blood Glucose RegulationPost-Absorptive PhaseOvernight Glucose & Insulin

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11A.04Page 38Blood Glucose RegulationPost-Absorptive PhaseInsulin/Glucagon Inverse Control

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11A.04Page 39Blood Glucose RegulationPost-Absorptive PhaseInsulin vs Glucagon Table

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11A.04Page 40Blood Glucose RegulationPost-Absorptive PhaseGlucagon Action

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11A.04Page 41Blood Glucose RegulationPost-Absorptive PhaseGlucagon Liver Signaling

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11A.04Page 42Blood Glucose RegulationPost-Absorptive PhaseGlucagon & Hepatic Glycogen

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11A.04Page 43Blood Glucose RegulationPost-Absorptive PhaseGlucagon PKA Mechanism

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11A.04Page 44Blood Glucose RegulationPost-Absorptive PhaseGlucagon: Summary

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11A.04Page 45Blood Glucose RegulationPost-Absorptive PhaseMain Post-Absorptive Reactions

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11A.04Page 46Blood Glucose RegulationPost-Absorptive PhaseGlucose Sources: Fasting Shift

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11A.04Page 47Blood Glucose RegulationPost-Absorptive PhaseFasting Pathways: Quantified

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11A.04Page 48Blood Glucose RegulationPost-Absorptive PhaseGluconeogenesis

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11A.04Page 49Blood Glucose RegulationPost-Absorptive PhaseLipolysis & Gluconeogenesis

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11A.04Page 50Blood Glucose RegulationPost-Absorptive PhaseOrgan Integration Diagram

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11A.04Page 51Blood Glucose RegulationPost-Absorptive PhaseFasting Metabolism Integration

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11A.04Page 52Blood Glucose RegulationShort & Prolonged Fasting

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11A.04Page 53Blood Glucose RegulationShort & Prolonged FastingHormonal Adaptation Table

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11A.04Page 54Blood Glucose RegulationShort & Prolonged FastingShort Fast Glucose Sources

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11A.04Page 55Blood Glucose RegulationShort & Prolonged FastingKetogenesis: Glucose Sparing

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11A.04Page 56Blood Glucose RegulationShort & Prolonged FastingProlonged Fast Glucose Sources

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11A.04Page 57Blood Glucose RegulationShort & Prolonged FastingFuel Shift: Day 3 vs Day 40

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11A.04Page 58Blood Glucose RegulationShort & Prolonged FastingStarvation Organ Integration

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11A.04Page 59Blood Glucose RegulationCounter-Regulatory Hormones

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11A.04Page 60Blood Glucose RegulationCounter-Regulatory HormonesHypoglycemia Response

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11A.04Page 61Blood Glucose RegulationCounter-Regulatory HormonesAdrenaline & Sympathetic Response

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11A.04Page 62Blood Glucose RegulationCounter-Regulatory HormonesCounter-Regulatory Summary

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