11B.03 · Cours 3 — Hormones thyroïdiennes

Course 3 — Thyroid hormones

Système endocrinien · 53 pages

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Course 3 — Thyroid hormones

Thyroid Hormones

2Section Outline 3Thyrotropic Axis Overview

Structure, Synthesis & Release

4Thyroid Gland Anatomy 5T4, T3, rT3 Structures 6Dietary Iodine Sources 7MIT Synthesis Step 8DIT Synthesis Step 9DIT+DIT Coupling → T4 10MIT+DIT Coupling → T3 11MIT+DIT Coupling → rT3 12Thyroglobulin Scaffold 13Follicle Microanatomy 14Follicular Cell Polarity 15Iodination/Organification 16T3/T4 Release 17Synthesis-Release Summary 18TSH-Stimulated Follicle 19Resting vs Stimulated Follicles

Thyroid Hormones

20Section Outline

Transport & Metabolism

21T4 vs T3 Comparison 22Progressive Deiodination 23Deiodination in Illness/Fasting 24Cell Entry Transporters

Thyroid Hormones

25Section Outline

Cellular Mode of Action

26T3 Nuclear Receptor Action 27TR Subtypes & Transcription

Thyroid Hormones

28Section Outline

Effects & Function

29Effects Overview 30Basal Metabolism Effects 31Growth & Development Effects 32Cardiovascular Effects 33T3 in Cardiomyocyte 34Other Effects

Thyroid Hormones

35Section Outline

Thyroid Activity Control

36HPT Axis Regulation 37Hypophysiotropic Hormones 38TSH Protein Structure 39TSH Receptor Binding 40T3 Negative Feedback 41Circadian TSH Regulation

Thyroid Hormones

42Section Outline

43Congenital Hypothyroidism 44Thyroid Dwarfism 45Delayed Bone Maturation 46Myxedema Symptoms 47Myxedema Puffy Face 48Hypothyroidism Causes 49Iodine Deficiency → Goiter 50Iodine Deficiency World Map 51Goiter Clinical Photos 52Hypothyroidism Evaluation 53Hyperthyroidism / Graves Disease

11B.03Page 1Course PlanWeek Agenda

Cours 3 — Hormones thyroïdiennes page 1

11B.03Page 2Thyroid HormonesSection Outline

Cours 3 — Hormones thyroïdiennes page 2

11B.03Page 3Thyroid HormonesThyrotropic Axis Overview

Cours 3 — Hormones thyroïdiennes page 3

11B.03Page 4Structure, Synthesis & ReleaseThyroid Gland Anatomy

Cours 3 — Hormones thyroïdiennes page 4

11B.03Page 5Structure, Synthesis & ReleaseT4, T3, rT3 Structures

Cours 3 — Hormones thyroïdiennes page 5

11B.03Page 6Structure, Synthesis & ReleaseDietary Iodine Sources

Cours 3 — Hormones thyroïdiennes page 6

11B.03Page 7Structure, Synthesis & ReleaseMIT Synthesis Step

Cours 3 — Hormones thyroïdiennes page 7

11B.03Page 8Structure, Synthesis & ReleaseDIT Synthesis Step

Cours 3 — Hormones thyroïdiennes page 8

11B.03Page 9Structure, Synthesis & ReleaseDIT+DIT Coupling → T4

Cours 3 — Hormones thyroïdiennes page 9

11B.03Page 10Structure, Synthesis & ReleaseMIT+DIT Coupling → T3

Cours 3 — Hormones thyroïdiennes page 10

11B.03Page 11Structure, Synthesis & ReleaseMIT+DIT Coupling → rT3

Cours 3 — Hormones thyroïdiennes page 11

11B.03Page 12Structure, Synthesis & ReleaseThyroglobulin Scaffold

Cours 3 — Hormones thyroïdiennes page 12

11B.03Page 13Structure, Synthesis & ReleaseFollicle Microanatomy

Cours 3 — Hormones thyroïdiennes page 13

11B.03Page 14Structure, Synthesis & ReleaseFollicular Cell Polarity

Cours 3 — Hormones thyroïdiennes page 14

11B.03Page 15Structure, Synthesis & ReleaseIodination/Organification

Cours 3 — Hormones thyroïdiennes page 15

11B.03Page 16Structure, Synthesis & ReleaseT3/T4 Release

Cours 3 — Hormones thyroïdiennes page 16

11B.03Page 17Structure, Synthesis & ReleaseSynthesis-Release Summary

Cours 3 — Hormones thyroïdiennes page 17

11B.03Page 18Structure, Synthesis & ReleaseTSH-Stimulated Follicle

Cours 3 — Hormones thyroïdiennes page 18

11B.03Page 19Structure, Synthesis & ReleaseResting vs Stimulated Follicles

Cours 3 — Hormones thyroïdiennes page 19

11B.03Page 20Thyroid HormonesSection Outline

Cours 3 — Hormones thyroïdiennes page 20

11B.03Page 21Transport & MetabolismT4 vs T3 Comparison

Cours 3 — Hormones thyroïdiennes page 21

11B.03Page 22Transport & MetabolismProgressive Deiodination

Cours 3 — Hormones thyroïdiennes page 22

11B.03Page 23Transport & MetabolismDeiodination in Illness/Fasting

Cours 3 — Hormones thyroïdiennes page 23

11B.03Page 24Transport & MetabolismCell Entry Transporters

Cours 3 — Hormones thyroïdiennes page 24

11B.03Page 25Thyroid HormonesSection Outline

Cours 3 — Hormones thyroïdiennes page 25

11B.03Page 26Cellular Mode of ActionT3 Nuclear Receptor Action

Cours 3 — Hormones thyroïdiennes page 26

11B.03Page 27Cellular Mode of ActionTR Subtypes & Transcription

Cours 3 — Hormones thyroïdiennes page 27

11B.03Page 28Thyroid HormonesSection Outline

Cours 3 — Hormones thyroïdiennes page 28

11B.03Page 29Effects & FunctionEffects Overview

Cours 3 — Hormones thyroïdiennes page 29

11B.03Page 30Effects & FunctionBasal Metabolism Effects

Cours 3 — Hormones thyroïdiennes page 30

11B.03Page 31Effects & FunctionGrowth & Development Effects

Cours 3 — Hormones thyroïdiennes page 31

11B.03Page 32Effects & FunctionCardiovascular Effects

Cours 3 — Hormones thyroïdiennes page 32

11B.03Page 33Effects & FunctionT3 in Cardiomyocyte

Cours 3 — Hormones thyroïdiennes page 33

11B.03Page 34Effects & FunctionOther Effects

Cours 3 — Hormones thyroïdiennes page 34

11B.03Page 35Thyroid HormonesSection Outline

Cours 3 — Hormones thyroïdiennes page 35

11B.03Page 36Thyroid Activity ControlHPT Axis Regulation

Cours 3 — Hormones thyroïdiennes page 36

11B.03Page 37Thyroid Activity ControlHypophysiotropic Hormones

Cours 3 — Hormones thyroïdiennes page 37

11B.03Page 38Thyroid Activity ControlTSH Protein Structure

Cours 3 — Hormones thyroïdiennes page 38

11B.03Page 39Thyroid Activity ControlTSH Receptor Binding

Cours 3 — Hormones thyroïdiennes page 39

11B.03Page 40Thyroid Activity ControlT3 Negative Feedback

Cours 3 — Hormones thyroïdiennes page 40

11B.03Page 41Thyroid Activity ControlCircadian TSH Regulation

Cours 3 — Hormones thyroïdiennes page 41

11B.03Page 42Thyroid HormonesSection Outline

Cours 3 — Hormones thyroïdiennes page 42

11B.03Page 43PathologiesCongenital Hypothyroidism

Cours 3 — Hormones thyroïdiennes page 43

11B.03Page 44PathologiesThyroid Dwarfism

Cours 3 — Hormones thyroïdiennes page 44

11B.03Page 45PathologiesDelayed Bone Maturation

Cours 3 — Hormones thyroïdiennes page 45

11B.03Page 46PathologiesMyxedema Symptoms

Cours 3 — Hormones thyroïdiennes page 46

11B.03Page 47PathologiesMyxedema Puffy Face

Cours 3 — Hormones thyroïdiennes page 47

11B.03Page 48PathologiesHypothyroidism Causes

Cours 3 — Hormones thyroïdiennes page 48

11B.03Page 49PathologiesIodine Deficiency → Goiter

Cours 3 — Hormones thyroïdiennes page 49

11B.03Page 50PathologiesIodine Deficiency World Map

Cours 3 — Hormones thyroïdiennes page 50

11B.03Page 51PathologiesGoiter Clinical Photos

Cours 3 — Hormones thyroïdiennes page 51

11B.03Page 52PathologiesHypothyroidism Evaluation

Cours 3 — Hormones thyroïdiennes page 52

11B.03Page 53PathologiesHyperthyroidism / Graves Disease

Cours 3 — Hormones thyroïdiennes page 53