11B.05 · Cours 5 — Axe CRH-ACTH-cortisol

Course 5 — CRH-ACTH-cortisol axis

Système endocrinien · 43 pages

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Course 5 — CRH-ACTH-cortisol axis

Weekly Course Agenda

1Weekly Course Agenda

Lecture Outline

2Lecture Outline

Generalities: Stress & Cortisol

3Corticotropic Axis Overview 4Cortisol: Adaptation Hormone 5Adrenal Gland Anatomy 6Cholesterol → Corticosteroids 7ACTH Steroidogenesis Regulation

Lecture Outline

8Lecture Outline

Corticotropic Axis Regulation

9Basal Regulation & Feedback 10Cortisol Circadian Rhythm 11Cortisol Daily Rhythm Pattern 12Jet Lag & Cortisol 13Jet Lag: Rhythm Reset 14Stress: Set-Point Shift 15Stress Definition & Types 16Surgical Stress: Cortisol Response 17CRH: Hypothalamic Signal 18CRH Neuron: CNS Inputs 19ACTH Structure (39 aa)20POMC Prohormone 21POMC Tissue-Specific Cleavage 22ACTH Mechanism of Action 23Zona Fasciculata: Cortisol Pathway 24Three-Zone Steroidogenesis 25Cortisol Transport & Metabolism 26Glucocorticoid Receptor Mechanism

Lecture Outline

27Lecture Outline

Cortisol Effects

28Metabolic Effects 29Other Organ Effects 30Nervous System Effects 31Anti-Inflammatory & Immune Inhibition

Lecture Outline

32Lecture Outline

33Cushing Disease 34Cushing: Clinical Signs 35Addison Disease 36Addison: Melanoderma 37ACTH-Driven Pigmentation

Lecture Outline

38Lecture Outline

Endocrine Stress Response

39Selye's Three-Phase Model 40Adrenaline vs Cortisol Response 41Adrenaline & Cortisol Actions 42Holmes-Rahe Stress Scale 43Stress Management Tips

11B.05Page 1Weekly Course Agenda

Cours 5 — Axe CRH-ACTH-cortisol page 1

11B.05Page 2Lecture Outline

Cours 5 — Axe CRH-ACTH-cortisol page 2

11B.05Page 3Generalities: Stress & CortisolCorticotropic Axis Overview

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11B.05Page 4Generalities: Stress & CortisolCortisol: Adaptation Hormone

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11B.05Page 5Generalities: Stress & CortisolAdrenal Gland Anatomy

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11B.05Page 6Generalities: Stress & CortisolCholesterol → Corticosteroids

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11B.05Page 7Generalities: Stress & CortisolACTH Steroidogenesis Regulation

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11B.05Page 8Lecture Outline

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11B.05Page 9Corticotropic Axis RegulationBasal Regulation & Feedback

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11B.05Page 10Corticotropic Axis RegulationCortisol Circadian Rhythm

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11B.05Page 11Corticotropic Axis RegulationCortisol Daily Rhythm Pattern

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11B.05Page 12Corticotropic Axis RegulationJet Lag & Cortisol

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11B.05Page 13Corticotropic Axis RegulationJet Lag: Rhythm Reset

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11B.05Page 14Corticotropic Axis RegulationStress: Set-Point Shift

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11B.05Page 15Corticotropic Axis RegulationStress Definition & Types

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11B.05Page 16Corticotropic Axis RegulationSurgical Stress: Cortisol Response

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11B.05Page 17Corticotropic Axis RegulationCRH: Hypothalamic Signal

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11B.05Page 18Corticotropic Axis RegulationCRH Neuron: CNS Inputs

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11B.05Page 19Corticotropic Axis RegulationACTH Structure (39 aa)

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11B.05Page 20Corticotropic Axis RegulationPOMC Prohormone

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11B.05Page 21Corticotropic Axis RegulationPOMC Tissue-Specific Cleavage

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11B.05Page 22Corticotropic Axis RegulationACTH Mechanism of Action

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11B.05Page 23Corticotropic Axis RegulationZona Fasciculata: Cortisol Pathway

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11B.05Page 24Corticotropic Axis RegulationThree-Zone Steroidogenesis

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11B.05Page 25Corticotropic Axis RegulationCortisol Transport & Metabolism

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11B.05Page 26Corticotropic Axis RegulationGlucocorticoid Receptor Mechanism

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11B.05Page 27Lecture Outline

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11B.05Page 28Cortisol EffectsMetabolic Effects

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11B.05Page 29Cortisol EffectsOther Organ Effects

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11B.05Page 30Cortisol EffectsNervous System Effects

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11B.05Page 31Cortisol EffectsAnti-Inflammatory & Immune Inhibition

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11B.05Page 32Lecture Outline

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11B.05Page 33PathologiesCushing Disease

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11B.05Page 34PathologiesCushing: Clinical Signs

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11B.05Page 35PathologiesAddison Disease

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11B.05Page 36PathologiesAddison: Melanoderma

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11B.05Page 37PathologiesACTH-Driven Pigmentation

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11B.05Page 38Lecture Outline

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11B.05Page 39Endocrine Stress ResponseSelye's Three-Phase Model

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11B.05Page 40Endocrine Stress ResponseAdrenaline vs Cortisol Response

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11B.05Page 41Endocrine Stress ResponseAdrenaline & Cortisol Actions

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11B.05Page 42Endocrine Stress ResponseHolmes-Rahe Stress Scale

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11B.05Page 43Endocrine Stress ResponseStress Management Tips

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