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11 · SMB3 · Digestif, endocrino, repro, os & pharmaco · 11C.01 · Développement sexuel · all pages
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11C.01 · Développement sexuel

Sexual development

Système reproducteur · 73 pages

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Sex Determination
1Sex Determination2Embryological question3Ancient: laterality theory4Ancient: temperature theory5Historical: female as male6Environmental factors9Chromosomal basis10XX/XY system11TDF & SRY discovery12X vs Y chromosomes13SRY function14ODF & WT1-KTS discovery15WT1-KTS & Frasier syndrome
Reproductive System Development
16Embryonic origins17Intermediate mesoderm, 3rd week19Embryo folding, 4th week20Urogenital ridges21Genital ridges & gonad primordia22Indifferent period: PGC migration25Indifferent period: somatic cells28Genital ridges & mesonephros29Indifferent period: genital ducts31Indifferent external genitalia
Reproductive Differentiation
32Differentiation overview33Gonadal differentiation37SRY vs WT1-KTS pathways38Molecular gene network39Three levels of sex40Classical experiments41Three levels of sex42Hormonal control43Hormonal control: male44Hormonal control: female45Genital duct differentiation46Male Wolffian duct47Female Müllerian duct49External genital homologues50Indifferent external genitalia51External genital differentiation52Gonadal descent
Puberty
53Primary vs secondary traits54Puberty onset timing55Puberty hormones56Tanner scale57Tanner scale stages58Puberty onset factors59Genetic factors: menarche60Environmental factors: menarche61Behavioral factors: menarche
Disorders of Sex Development
62Overview63Müllerian fusion defects64Intersex introduction65DSD definition66Sex chromosome DSD6746,XX DSD categories6846,XX DSD: CAH7046,XY DSD categories7146,XY DSD: incomplete masculinization7246,XY DSD: androgen insensitivity
Sex Determination
73Pathway summary