11D.03Page 1Introduction
11D.03 · Remodelage osseux
Bone remodeling
Métabolisme osseux et minéral · 52 pages
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11D.03Page 2Learning Objectives
11D.03Page 3Evolutionary Context
11D.03Page 4Bone as Calcium Reservoir
11D.03Page 5Remodeling Definition
11D.03Page 6Remodeling TypesSurface Remodeling
11D.03Page 7Remodeling TypesIntracortical Remodeling
11D.03Page 10Targeted RemodelingMicrodamage Repair
11D.03Page 12Targeted RemodelingOsteocyte RANKL/OPG Signaling
11D.03Page 13Targeted RemodelingStress Fractures
11D.03Page 15Remodeling Cellular MechanismsOsteoclast Machinery
11D.03Page 16Resorption RegulationSystemic & Local Regulators
11D.03Page 17Resorption RegulationCytokine-driven Bone Loss
11D.03Page 18RANKL/OPG AxisRANKL Activates Osteoclasts
11D.03Page 19RANKL/OPG AxisExcess RANKL → Bone Loss
11D.03Page 20RANKL/OPG AxisRANK KO: Osteopetrosis
11D.03Page 21RANKL/OPG AxisOPG Decoy Mechanism
11D.03Page 22RANKL/OPG AxisOPG → Osteoclast Apoptosis
11D.03Page 23RANKL/OPG AxisOPG Dose & BMD
11D.03Page 24RANKL/OPG AxisOC Mutations & Osteopetrosis
11D.03Page 25CouplingCoupling Factors (TGF-β, IGF-1, BMPs)
11D.03Page 26Bone Formation RegulationSystemic & Local Regulators
11D.03Page 27Bone Formation RegulationIGF-1 & Bone Formation
11D.03Page 28Bone ModelingModeling Definition
11D.03Page 29Bone ModelingMechanical Stimulation & Modeling
11D.03Page 30Bone ModelingLoading Suppresses Sclerostin
11D.03Page 32Sclerostin/Osteocyte AxisSclerostin KO Phenotype
11D.03Page 35Hormonal Regulation
11D.03Page 36Hormonal RegulationPTH Structure
11D.03Page 37Hormonal RegulationPTH Target Organs
11D.03Page 38Hormonal RegulationCalcium–PTH Feedback
11D.03Page 39Hormonal RegulationLow Calcium, High PTH, Bone Loss
11D.03Page 40Hormonal RegulationPTH/PTHrP Shared Receptor
11D.03Page 41Hormonal RegulationPTH Stimulates Bone Resorption
11D.03Page 42Hormonal RegulationPTH on Osteoblast Lineage
11D.03Page 43Hormonal RegulationPTH Inhibits Sclerostin
11D.03Page 44Hormonal RegulationPTH Net Bone Effects
11D.03Page 45Hormonal RegulationContinuous PTH & Bone Loss
11D.03Page 46Hormonal RegulationEstrogen Actions on Bone
11D.03Page 47Hormonal RegulationEstrogens vs PTH on Bone Mass
11D.03Page 48Lactation & BoneLactation Hormonal Regulation
11D.03Page 49Lactation & BoneTrabecular & Cortical Bone Loss
11D.03Page 50Lactation & BoneRecovery After Weaning
11D.03Page 51Lactation & BoneSpine BMD: Lactation & Recovery
11D.03Page 52Closing
