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11 · SMB3 · Digestif, endocrino, repro, os & pharmaco · 11E.02 · Principes de base de la pharmacologie · all pages
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11E.02 · Principes de base de la pharmacologie

Basic principles of pharmacology

Pharmacologie · 53 pages

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Course Introduction
1Course Introduction
Curriculum Overview
2Curriculum Overview
Reference Textbooks
3Reference Textbooks
Core Definitions
4Pharmacology & Pharmacy5PK, PD & Pharmacogenetics
Pharmacology Disciplines
6Experimental Pharmacology7Clinical Pharmacology
Core Definitions
8Drug Definition
Prescription to Effect
9Prescription to Effect
Course Objectives
10Course Objectives
Lecture Objectives
11Lecture Objectives
ADME Pathway Overview
12ADME Pathway Overview
Absorption
13Routes of Administration14Bilayer Crossing Mechanisms15Passive Diffusion16Fick's First Law17Lipophilicity & log P18Henderson-Hasselbalch Equation19Ionization & Body pH20Bilayer Crossing Mechanisms21Active Transport22Major Drug Transporters23P-Glycoprotein Efflux Pump
Metabolism
24Metabolism25Liver: Lipophilic to Hydrophilic26Liver Anatomy & Function27Phase I Reactions28Cytochrome P450 Structure29CYP450 Isoenzymes30CYP450 Inhibition & Induction31CYP450 Substrate/Inhibitor/Inducer Table32CYP450 Genetic Polymorphism33Metabolizer Phenotypes34CYP2D6 Clinical Example35Phase II Reactions36UGTs & SULTs37Amitriptyline Biotransformation38Extrahepatic Metabolism
Distribution
39Organ Perfusion & Capillaries40Blood-Tissue Barriers41Plasma Protein Binding42Binding Equilibrium43Free Fraction Effects
Excretion
44Renal Nephron45Glomerular Filtration46Tubular Reabsorption47Urinary pH & Elimination48Tubular Secretion
Summary
49Summary50Absorption Summary51Metabolism Summary52Distribution Summary53Excretion Summary