12.04 · Répertoires B et T

B and T repertoires

SMB4 Systèmes physiologiques 2 Immunologie, inflammation, transplantation · 27 pages

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B and T repertoires

B and T Repertoires

1B and T Repertoires

TCR and BCR Structure

2TCR vs BCR Overview 3Antibody Structure 4Immunoglobulin Domains as Building Blocks 5Structural Similarity of TCR and Antibody 6Hypervariable Regions and CDR Loops

Repertoire Diversity Principle

7Lottery Analogy for Receptor Diversity

V(D)J Recombination

8Heavy Chain Gene Segments and VDJ Joining 9BCR Heavy Chain vs TCR Beta Chain Loci 10BCR Light Chain and TCR Alpha Chain (V-J Only)11RAG Mechanism and DNA Cleavage Steps 12Hairpin Opening and P Nucleotides 13N Nucleotide Addition by TdT

Reading Frame Consequences

14Three Reading Frames — Frame 1 15Three Reading Frames — Frame 2 16Three Reading Frames — Frame 3 17Only 1 in 3 Junctions Are Productive

Quality Control Checkpoints

18Pre-BCR and Pre-TCR Surrogate Chain Test 19Post-Checkpoint: RAG Off and Allelic Exclusion 20Multiple Light Chain Rearrangement Attempts 21Final BCR Surface Test and TCR Positive Selection 22Successful BCR: RAG Off and Surface Expression 23BCR Rearrangement Overview Flowchart

B-Cell Self-Tolerance

24Elimination of Autoreactive B Cells 25Receptor Editing as Last Chance

Lymphocyte Circulation

26Entry into Blood-Lymph Circuit

12.04Page 1B and T Repertoires

Répertoires B et T page 1

12.04Page 2TCR and BCR StructureTCR vs BCR Overview

Répertoires B et T page 2

12.04Page 3TCR and BCR StructureAntibody Structure

Répertoires B et T page 3

12.04Page 4TCR and BCR StructureImmunoglobulin Domains as Building Blocks

Répertoires B et T page 4

12.04Page 5TCR and BCR StructureStructural Similarity of TCR and Antibody

Répertoires B et T page 5

12.04Page 6TCR and BCR StructureHypervariable Regions and CDR Loops

Répertoires B et T page 6

12.04Page 7Repertoire Diversity PrincipleLottery Analogy for Receptor Diversity

Répertoires B et T page 7

12.04Page 8V(D)J RecombinationHeavy Chain Gene Segments and VDJ Joining

Répertoires B et T page 8

12.04Page 9V(D)J RecombinationBCR Heavy Chain vs TCR Beta Chain Loci

Répertoires B et T page 9

12.04Page 10V(D)J RecombinationBCR Light Chain and TCR Alpha Chain (V-J Only)

Répertoires B et T page 10

12.04Page 11V(D)J RecombinationRAG Mechanism and DNA Cleavage Steps

Répertoires B et T page 11

12.04Page 12V(D)J RecombinationHairpin Opening and P Nucleotides

Répertoires B et T page 12

12.04Page 13V(D)J RecombinationN Nucleotide Addition by TdT

Répertoires B et T page 13

12.04Page 14Reading Frame ConsequencesThree Reading Frames — Frame 1

Répertoires B et T page 14

12.04Page 15Reading Frame ConsequencesThree Reading Frames — Frame 2

Répertoires B et T page 15

12.04Page 16Reading Frame ConsequencesThree Reading Frames — Frame 3

Répertoires B et T page 16

12.04Page 17Reading Frame ConsequencesOnly 1 in 3 Junctions Are Productive

Répertoires B et T page 17

12.04Page 18Quality Control CheckpointsPre-BCR and Pre-TCR Surrogate Chain Test

Répertoires B et T page 18

12.04Page 19Quality Control CheckpointsPost-Checkpoint: RAG Off and Allelic Exclusion

Répertoires B et T page 19

12.04Page 20Quality Control CheckpointsMultiple Light Chain Rearrangement Attempts

Répertoires B et T page 20

12.04Page 21Quality Control CheckpointsFinal BCR Surface Test and TCR Positive Selection

Répertoires B et T page 21

12.04Page 22Quality Control CheckpointsSuccessful BCR: RAG Off and Surface Expression

Répertoires B et T page 22

12.04Page 23Quality Control CheckpointsBCR Rearrangement Overview Flowchart

Répertoires B et T page 23

12.04Page 24B-Cell Self-ToleranceElimination of Autoreactive B Cells

Répertoires B et T page 24

12.04Page 25B-Cell Self-ToleranceReceptor Editing as Last Chance

Répertoires B et T page 25

12.04Page 26Lymphocyte CirculationEntry into Blood-Lymph Circuit

Répertoires B et T page 26

12.04Page 27Key Messages

Répertoires B et T page 27