12.13 · Transplantation — jour 2

Transplantation — day 2

SMB4 Systèmes physiologiques 2 Immunologie, inflammation, transplantation · 56 pages

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Organ & HSC Transplantation

1Organ & HSC Transplantation

Graft Rejection

2Rejection Types Overview

Hyperacute Rejection

4Preformed Antibodies Mechanism 5ABO and Anti-HLA Antibodies 6Routes of Anti-HLA Immunization 7Gross and Histological Damage 8Cross-Match Test

9Rejection Types Overview

Cellular Rejection Mechanisms

10Natural Graft Rejection Pathway 11T-Cell Infiltration Histology 12Direct vs Indirect Antigen Presentation 13Direct and Indirect Presentation Signals 14MHC vs Minor Antigen Barriers 15T-Cell Cross-Reactivity with Foreign HLA 16Thymic Selection and Escape 17MHC Restriction Principle 18Alloreactivity Mechanisms 19Rejection as TCR Side Effect 20Three Activation Signals 21Steps of Graft Destruction 22Recipient Cellular Immune Response

Immunosuppressive Treatment

23Prevention Principle — Lifelong 24Drug Targets in T-Cell Rejection 25Signaling Pathway Drug Map 26Induction, Maintenance & Acute Regimens

Chronic Rejection

27Chronic Graft Nephropathy Overview 28Immunologic and Non-Immunologic Factors

29Complications of Treatment

Organ Transplantation Practical Considerations

30Donor Selection & Complications 31Kidney Graft Survival vs HLA Mismatch 32Graft Survival by Organ Type

Hematopoietic Stem Cell Transplantation

12.13Page 1Organ & HSC Transplantation

Transplantation — jour 2 page 1

12.13Page 2Graft RejectionRejection Types Overview

Transplantation — jour 2 page 2

12.13Page 3Graft RejectionRejection Types Overview

Transplantation — jour 2 page 3

12.13Page 4Graft RejectionHyperacute RejectionPreformed Antibodies Mechanism

Transplantation — jour 2 page 4

12.13Page 5Graft RejectionHyperacute RejectionABO and Anti-HLA Antibodies

Transplantation — jour 2 page 5

12.13Page 6Graft RejectionHyperacute RejectionRoutes of Anti-HLA Immunization

Transplantation — jour 2 page 6

12.13Page 7Graft RejectionHyperacute RejectionGross and Histological Damage

Transplantation — jour 2 page 7

12.13Page 8Graft RejectionHyperacute RejectionCross-Match Test

Transplantation — jour 2 page 8

12.13Page 9Graft RejectionRejection Types Overview

Transplantation — jour 2 page 9

12.13Page 10Graft RejectionCellular Rejection MechanismsNatural Graft Rejection Pathway

Transplantation — jour 2 page 10

12.13Page 11Graft RejectionCellular Rejection MechanismsT-Cell Infiltration Histology

Transplantation — jour 2 page 11

12.13Page 12Graft RejectionCellular Rejection MechanismsDirect vs Indirect Antigen Presentation

Transplantation — jour 2 page 12

12.13Page 13Graft RejectionCellular Rejection MechanismsDirect and Indirect Presentation Signals

Transplantation — jour 2 page 13

12.13Page 14Graft RejectionCellular Rejection MechanismsMHC vs Minor Antigen Barriers

Transplantation — jour 2 page 14

12.13Page 15Graft RejectionCellular Rejection MechanismsT-Cell Cross-Reactivity with Foreign HLA

Transplantation — jour 2 page 15

12.13Page 16Graft RejectionCellular Rejection MechanismsThymic Selection and Escape

Transplantation — jour 2 page 16

12.13Page 17Graft RejectionCellular Rejection MechanismsMHC Restriction Principle

Transplantation — jour 2 page 17

12.13Page 18Graft RejectionCellular Rejection MechanismsAlloreactivity Mechanisms

Transplantation — jour 2 page 18

12.13Page 19Graft RejectionCellular Rejection MechanismsRejection as TCR Side Effect

Transplantation — jour 2 page 19

12.13Page 20Graft RejectionCellular Rejection MechanismsThree Activation Signals

Transplantation — jour 2 page 20

12.13Page 21Graft RejectionCellular Rejection MechanismsSteps of Graft Destruction

Transplantation — jour 2 page 21

12.13Page 22Graft RejectionCellular Rejection MechanismsRecipient Cellular Immune Response

Transplantation — jour 2 page 22

12.13Page 23Graft RejectionImmunosuppressive TreatmentPrevention Principle — Lifelong

Transplantation — jour 2 page 23

12.13Page 24Graft RejectionImmunosuppressive TreatmentDrug Targets in T-Cell Rejection

Transplantation — jour 2 page 24

12.13Page 25Graft RejectionImmunosuppressive TreatmentSignaling Pathway Drug Map

Transplantation — jour 2 page 25

12.13Page 26Graft RejectionImmunosuppressive TreatmentInduction, Maintenance & Acute Regimens

Transplantation — jour 2 page 26

12.13Page 27Graft RejectionChronic RejectionChronic Graft Nephropathy Overview

Transplantation — jour 2 page 27

12.13Page 28Graft RejectionChronic RejectionImmunologic and Non-Immunologic Factors

Transplantation — jour 2 page 28

12.13Page 29Graft RejectionComplications of Treatment

Transplantation — jour 2 page 29

12.13Page 30Organ Transplantation Practical ConsiderationsDonor Selection & Complications

Transplantation — jour 2 page 30

12.13Page 31Organ Transplantation Practical ConsiderationsKidney Graft Survival vs HLA Mismatch

Transplantation — jour 2 page 31

12.13Page 32Organ Transplantation Practical ConsiderationsGraft Survival by Organ Type

Transplantation — jour 2 page 32

12.13Page 33Hematopoietic Stem Cell TransplantationIntroduction to HSC

Transplantation — jour 2 page 33

12.13Page 34Hematopoietic Stem Cell TransplantationHematopoiesisLineage Tree — Cell Types

Transplantation — jour 2 page 34

12.13Page 35Hematopoietic Stem Cell TransplantationHematopoiesisCytokines and Transcription Factors

Transplantation — jour 2 page 35

12.13Page 36Hematopoietic Stem Cell TransplantationHematopoiesisFour Functional Compartments

Transplantation — jour 2 page 36

12.13Page 37Hematopoietic Stem Cell TransplantationHematopoiesisFull Lineage Diagram

Transplantation — jour 2 page 37

12.13Page 38Hematopoietic Stem Cell TransplantationHematopoiesisCompartment Definitions

Transplantation — jour 2 page 38

12.13Page 39Hematopoietic Stem Cell TransplantationStem Cell Plasticity

Transplantation — jour 2 page 39

12.13Page 40Hematopoietic Stem Cell TransplantationHSC Transplant ProcedureConditioning and Graft Preparation

Transplantation — jour 2 page 40

12.13Page 41Hematopoietic Stem Cell TransplantationHSC Transplant ProcedureTransplant Sequence

Transplantation — jour 2 page 41

12.13Page 42Hematopoietic Stem Cell TransplantationHSC Transplant ProcedureClinical Indications

Transplantation — jour 2 page 42

12.13Page 43Hematopoietic Stem Cell TransplantationHSC Transplant ProcedureAutologous vs Allogeneic

Transplantation — jour 2 page 43

12.13Page 44Hematopoietic Stem Cell TransplantationImmune OutcomesThree Scenarios: Success, Rejection, GVHD

Transplantation — jour 2 page 44

12.13Page 45Hematopoietic Stem Cell TransplantationImmune OutcomesScenario A — Successful Engraftment

Transplantation — jour 2 page 45

12.13Page 46Hematopoietic Stem Cell TransplantationImmune OutcomesScenario B — Host-vs-Graft Rejection

Transplantation — jour 2 page 46

12.13Page 47Hematopoietic Stem Cell TransplantationImmune OutcomesScenario C — Graft-vs-Host Disease

Transplantation — jour 2 page 47

12.13Page 48Hematopoietic Stem Cell TransplantationImmune OutcomesOrgan vs HSC Transplant Contrast

Transplantation — jour 2 page 48

12.13Page 49Hematopoietic Stem Cell TransplantationImmune OutcomesGraft Sources and GVH/GVL/GVI Effects

Transplantation — jour 2 page 49

12.13Page 50Hematopoietic Stem Cell TransplantationImmune OutcomesGVH vs GVL — Harmful and Beneficial

Transplantation — jour 2 page 50

12.13Page 51Hematopoietic Stem Cell TransplantationHematopoietic Reconstitution Timeline

Transplantation — jour 2 page 51

12.13Page 52Hematopoietic Stem Cell TransplantationPractical Considerations

Transplantation — jour 2 page 52

12.13Page 53Hematopoietic Stem Cell TransplantationDonor SelectionFamily Donor HLA Haplotypes

Transplantation — jour 2 page 53

12.13Page 54Hematopoietic Stem Cell TransplantationDonor SelectionInternational Unrelated Donor Registries

Transplantation — jour 2 page 54

12.13Page 55Hematopoietic Stem Cell TransplantationDonor SelectionPhenotypic vs Allele-Level HLA Typing

Transplantation — jour 2 page 55

12.13Page 56Hematopoietic Stem Cell TransplantationDonor SelectionSwiss Donor Registration

Transplantation — jour 2 page 56