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14.02 · Maladies de l’hémostase III

Hemostasis disorders III

Hémostase · 130 pages

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1Hemostasis Disorders III
2Primary Hemostasis Review3Platelet Adhesion4Platelet Activation5Fibrinogen Binding & Aggregation6Platelet Structure7Platelet Plug Formation
8Three Phases of Hemostasis
9Course Objectives
10Course Outline11Overview12Role of Coagulation13Transition to Players
Coagulation Players
14Coagulation Players15Tissue Factor16Tissue Factor Sources17Factor Classification18Factor Nomenclature Table19Hepatic Synthesis & Vitamin K20Vitamin K Sources & Deficiency21Vitamin K-Dependent Binding22Vitamin K Metabolism23Fibrinogen24Fibrinogen Structure25Factor XIII
26Transition to Scenario
Coagulation Scenario
27Coagulation Scenario28Thrombin Generation Overview29Phospholipids & Calcium30Vitamin K-Dependent Factor Roles31Tenase & Prothrombinase Complexes32Prothrombinase Amplification33Initiation Phase34Amplification Phase35Propagation Phase36Scenario Summary37Fibrin Formation38Fibrin Polymerization39Visual Summary
40Quiz: Coagulation Factors41Quiz: Thrombin Generation42Quiz: Fibrinogen
43Break
44Overview
Bleeding History
45Bleeding History46Constitutional vs Acquired47Constitutional vs Acquired Patterns
48Physical Exam & Lab Overview
Coagulation Tests
49Screening Tests Overview50Blood Collection51Centrifugation52Lab Coagulation Pathways53Extrinsic Pathway54Intrinsic Pathway55Prothrombin Time / Quick Time56PT/Quick Pathway Coverage57INR Standardization58aPTT Method59aPTT Pathway Coverage60Thrombin Time61TT Pathway Coverage
Test Interpretation
62Screening Test Summary63Isolated Low Quick: Factor VII64Isolated Prolonged aPTT65aPTT Prolongation Workup66Factor Reference Range67VKA Pattern: PT & aPTT Prolonged68Vitamin K Deficiency vs Liver Disease69All Tests Prolonged: DIC or Liver70Liver Role in Hemostasis
71Overview72Role of Fibrinolysis73Fibrinolysis Players74Fibrinolysis Scenario75Lab Assessment
D-Dimers
76D-Dimers77D-Dimer Interpretation
78Hyperfibrinolysis79Disseminated Intravascular Coagulation80Complex Coagulopathy Lab Pattern81Visual Summary
82Quiz: Isolated Prolonged aPTT83Quiz: Coagulation Times
84Quiz: Fibrinolysis
85Break
86Overview
Hemostasis Balance
87Hemostasis Balance88Imbalance Toward Bleeding89Imbalance Toward Thrombosis
90Thrombin Amplification Roles91Antithrombin92TFPI93Protein C & Protein S94Thrombomodulin System95Inhibitor Summary
Endothelium Role
96Endothelium Role97Thrombo-Resistant Properties
98Quiz: Coagulation Inhibitors
99Overview100Hemophilia Definition101Normal vs Hemophilia Coagulation102Hemophilia Mechanism
Severity Classification
103Severity Classification104Symptom Patterns by Severity
Bleeding Patterns
105Bleeding Sites106Hemarthrosis
Genetics & Inheritance
107Genetics & Inheritance108Hemophilia in Women
Treatment
109Factor Replacement110Treatment Goal: Restore Balance111On-Demand vs Prophylaxis112Treatment Products
Advanced Treatments
113Treatment Evolution114Non-Factor Therapies115Emicizumab116Gene Therapy
Adjunct Therapies
117Antifibrinolytics118Desmopressin (DDAVP)
Rare Factor Deficiencies
119Rare Factor Deficiencies120Prevalence Comparison121Factor Level-Symptom Thresholds122Specific Bleeding Patterns123Fibrinogen Disorders124Factor XI Deficiency125Factor XI Coagulation Role
126Quiz: Hemophilia127Quiz: Hemophilia Treatment128Quiz: Factor XI Deficiency129Quiz: Hemophilia Lab Profile
130Hemostasis Disorders III