15G.08 · Sexe et genre — recherche et clinique

Sex and gender — research and clinical care

Personne, Santé, Société (PSS) 2025-2026 · 42 pages

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Sex & Gender Medicine

1Sex & Gender Medicine 3Joint Influence on Health 4Definition 5Lecture Outline

1. Clinical Differences

61. Clinical Differences 7Cardiac Anatomy 8Cardiac Physiology Table 9Blood Pressure Example

Blood Pressure Example

10BP Across Lifespan 11SBP Elevation From Baseline 12BP Difference Hypotheses

1. Clinical Differences

13Myocardial Infarction Example

Myocardial Infarction Example

14Sex Hormones & CV Biology 15MI Sex/Gender Pathway 16MI Symptoms by Sex 17MI Symptoms in Women 18Diagnostic Delay in Women 19MI Mortality Consequences 20False Optimism & Risk

1. Clinical Differences

21Depression Example

Depression Example

22Frequency vs Mortality 23Symptoms by Sex 24Male Symptom Scale Data 25Reporting Gender Bias 26Masked Depression in Men 27Underdiagnosis in Men

28Broader Health Determinants 29Lecture Outline (Recap)

2. Management & Prescribing

30Drug Effects by Sex 31Pharmacokinetic Differences 32Pain Prescribing Bias 33Painkiller Use by Sex/Age 34Yentl Syndrome

35Lecture Outline (Recap)

3. Sex/Gender in Research

36Male-Default Studies 37Inclusion by Discipline 38ESC Guidelines Bias 39Women's Trial Inclusion 40Policy & Mandates

41Take-Home Summary 42Sex & Gender Medicine

15G.08Page 1Sex & Gender Medicine

Sexe et genre — recherche et clinique page 1

15G.08Page 2Sex & Gender Medicine

Sexe et genre — recherche et clinique page 2

15G.08Page 3Sex & Gender MedicineJoint Influence on Health

Sexe et genre — recherche et clinique page 3

15G.08Page 4Sex & Gender MedicineDefinition

Sexe et genre — recherche et clinique page 4

15G.08Page 5Sex & Gender MedicineLecture Outline

Sexe et genre — recherche et clinique page 5

15G.08Page 6Sex & Gender Medicine1. Clinical Differences

Sexe et genre — recherche et clinique page 6

15G.08Page 7Sex & Gender Medicine1. Clinical DifferencesCardiac Anatomy

Sexe et genre — recherche et clinique page 7

15G.08Page 8Sex & Gender Medicine1. Clinical DifferencesCardiac Physiology Table

Sexe et genre — recherche et clinique page 8

15G.08Page 9Sex & Gender Medicine1. Clinical DifferencesBlood Pressure Example

Sexe et genre — recherche et clinique page 9

15G.08Page 10Sex & Gender Medicine1. Clinical DifferencesBlood Pressure ExampleBP Across Lifespan

Sexe et genre — recherche et clinique page 10

15G.08Page 11Sex & Gender Medicine1. Clinical DifferencesBlood Pressure ExampleSBP Elevation From Baseline

Sexe et genre — recherche et clinique page 11

15G.08Page 12Sex & Gender Medicine1. Clinical DifferencesBlood Pressure ExampleBP Difference Hypotheses

Sexe et genre — recherche et clinique page 12

15G.08Page 13Sex & Gender Medicine1. Clinical DifferencesMyocardial Infarction Example

Sexe et genre — recherche et clinique page 13

15G.08Page 14Sex & Gender Medicine1. Clinical DifferencesMyocardial Infarction ExampleSex Hormones & CV Biology

Sexe et genre — recherche et clinique page 14

15G.08Page 15Sex & Gender Medicine1. Clinical DifferencesMyocardial Infarction ExampleMI Sex/Gender Pathway

Sexe et genre — recherche et clinique page 15

15G.08Page 16Sex & Gender Medicine1. Clinical DifferencesMyocardial Infarction ExampleMI Symptoms by Sex

Sexe et genre — recherche et clinique page 16

15G.08Page 17Sex & Gender Medicine1. Clinical DifferencesMyocardial Infarction ExampleMI Symptoms in Women

Sexe et genre — recherche et clinique page 17

15G.08Page 18Sex & Gender Medicine1. Clinical DifferencesMyocardial Infarction ExampleDiagnostic Delay in Women

Sexe et genre — recherche et clinique page 18

15G.08Page 19Sex & Gender Medicine1. Clinical DifferencesMyocardial Infarction ExampleMI Mortality Consequences

Sexe et genre — recherche et clinique page 19

15G.08Page 20Sex & Gender Medicine1. Clinical DifferencesMyocardial Infarction ExampleFalse Optimism & Risk

Sexe et genre — recherche et clinique page 20

15G.08Page 21Sex & Gender Medicine1. Clinical DifferencesDepression Example

Sexe et genre — recherche et clinique page 21

15G.08Page 22Sex & Gender Medicine1. Clinical DifferencesDepression ExampleFrequency vs Mortality

Sexe et genre — recherche et clinique page 22

15G.08Page 23Sex & Gender Medicine1. Clinical DifferencesDepression ExampleSymptoms by Sex

Sexe et genre — recherche et clinique page 23

15G.08Page 24Sex & Gender Medicine1. Clinical DifferencesDepression ExampleMale Symptom Scale Data

Sexe et genre — recherche et clinique page 24

15G.08Page 25Sex & Gender Medicine1. Clinical DifferencesDepression ExampleReporting Gender Bias

Sexe et genre — recherche et clinique page 25

15G.08Page 26Sex & Gender Medicine1. Clinical DifferencesDepression ExampleMasked Depression in Men

Sexe et genre — recherche et clinique page 26

15G.08Page 27Sex & Gender Medicine1. Clinical DifferencesDepression ExampleUnderdiagnosis in Men

Sexe et genre — recherche et clinique page 27

15G.08Page 28Sex & Gender MedicineBroader Health Determinants

Sexe et genre — recherche et clinique page 28

15G.08Page 29Sex & Gender MedicineLecture Outline (Recap)

Sexe et genre — recherche et clinique page 29

15G.08Page 30Sex & Gender Medicine2. Management & PrescribingDrug Effects by Sex

Sexe et genre — recherche et clinique page 30

15G.08Page 31Sex & Gender Medicine2. Management & PrescribingPharmacokinetic Differences

Sexe et genre — recherche et clinique page 31

15G.08Page 32Sex & Gender Medicine2. Management & PrescribingPain Prescribing Bias

Sexe et genre — recherche et clinique page 32

15G.08Page 33Sex & Gender Medicine2. Management & PrescribingPainkiller Use by Sex/Age

Sexe et genre — recherche et clinique page 33

15G.08Page 34Sex & Gender Medicine2. Management & PrescribingYentl Syndrome

Sexe et genre — recherche et clinique page 34

15G.08Page 35Sex & Gender MedicineLecture Outline (Recap)

Sexe et genre — recherche et clinique page 35

15G.08Page 36Sex & Gender Medicine3. Sex/Gender in ResearchMale-Default Studies

Sexe et genre — recherche et clinique page 36

15G.08Page 37Sex & Gender Medicine3. Sex/Gender in ResearchInclusion by Discipline

Sexe et genre — recherche et clinique page 37

15G.08Page 38Sex & Gender Medicine3. Sex/Gender in ResearchESC Guidelines Bias

Sexe et genre — recherche et clinique page 38

15G.08Page 39Sex & Gender Medicine3. Sex/Gender in ResearchWomen's Trial Inclusion

Sexe et genre — recherche et clinique page 39

15G.08Page 40Sex & Gender Medicine3. Sex/Gender in ResearchPolicy & Mandates

Sexe et genre — recherche et clinique page 40

15G.08Page 41Sex & Gender MedicineTake-Home Summary

Sexe et genre — recherche et clinique page 41

15G.08Page 42Sex & Gender Medicine

Sexe et genre — recherche et clinique page 42