01A.06 · Mucoviscidose VI — atteinte gastro-intestinale

Cystic fibrosis VI — gastrointestinal involvement

Cystic fibrosis series · 35 pages

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GI manifestations of cystic fibrosis

1GI manifestations of cystic fibrosis 2Life expectancy and causes of death 3Quality of life impact 4Prevalence of GI symptoms 5CF as a multisystem disease 6Primary vs secondary GI manifestations

Proximal digestive tract

7Overview 8Gastroesophageal reflux — prevalence 9Gastroesophageal reflux — pathophysiology

Distal digestive tract

10Overview 11Pathophysiology 12Symptoms

13Multisystem disease — transition to liver

Liver involvement

14Normal liver functions 15Biliary physiology — CFTR in cholangiocytes 16Cholestasis pathophysiology 17Symptoms overview 18Hepatomegaly 19Portal hypertension 20Respiratory impact — restrictive syndrome

21Multisystem disease — transition to pancreas

Pancreatic involvement

22Normal exocrine physiology 23Exocrine pathophysiology 24Terminal pancreatic insufficiency 25Exocrine symptoms 26Summary — genotype to malabsorption

27GI symptom prevalence — recap

28Current GI therapies 29CFTR modulators — digestive effects?

30Closing — quality of life 31Closing 33Appendix — multisystem disease diagram 34Appendix — SBBO vicious cycle 35Appendix — energy deficit summary

01A.06Page 1GI manifestations of cystic fibrosis

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01A.06Page 2GI manifestations of cystic fibrosisLife expectancy and causes of death

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01A.06Page 3GI manifestations of cystic fibrosisQuality of life impact

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01A.06Page 4GI manifestations of cystic fibrosisPrevalence of GI symptoms

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01A.06Page 5GI manifestations of cystic fibrosisCF as a multisystem disease

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01A.06Page 6GI manifestations of cystic fibrosisPrimary vs secondary GI manifestations

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01A.06Page 7GI manifestations of cystic fibrosisProximal digestive tractOverview

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01A.06Page 8GI manifestations of cystic fibrosisProximal digestive tractGastroesophageal reflux — prevalence

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01A.06Page 9GI manifestations of cystic fibrosisProximal digestive tractGastroesophageal reflux — pathophysiology

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01A.06Page 10GI manifestations of cystic fibrosisDistal digestive tractOverview

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01A.06Page 11GI manifestations of cystic fibrosisDistal digestive tractPathophysiology

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01A.06Page 12GI manifestations of cystic fibrosisDistal digestive tractSymptoms

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01A.06Page 13GI manifestations of cystic fibrosisMultisystem disease — transition to liver

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01A.06Page 14GI manifestations of cystic fibrosisLiver involvementNormal liver functions

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01A.06Page 15GI manifestations of cystic fibrosisLiver involvementBiliary physiology — CFTR in cholangiocytes

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01A.06Page 16GI manifestations of cystic fibrosisLiver involvementCholestasis pathophysiology

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01A.06Page 17GI manifestations of cystic fibrosisLiver involvementSymptoms overview

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01A.06Page 18GI manifestations of cystic fibrosisLiver involvementHepatomegaly

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01A.06Page 19GI manifestations of cystic fibrosisLiver involvementPortal hypertension

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01A.06Page 20GI manifestations of cystic fibrosisLiver involvementRespiratory impact — restrictive syndrome

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01A.06Page 21GI manifestations of cystic fibrosisMultisystem disease — transition to pancreas

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01A.06Page 22GI manifestations of cystic fibrosisPancreatic involvementNormal exocrine physiology

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01A.06Page 23GI manifestations of cystic fibrosisPancreatic involvementExocrine pathophysiology

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01A.06Page 24GI manifestations of cystic fibrosisPancreatic involvementTerminal pancreatic insufficiency

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01A.06Page 25GI manifestations of cystic fibrosisPancreatic involvementExocrine symptoms

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01A.06Page 26GI manifestations of cystic fibrosisPancreatic involvementSummary — genotype to malabsorption

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01A.06Page 27GI manifestations of cystic fibrosisGI symptom prevalence — recap

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01A.06Page 28GI manifestations of cystic fibrosisTreatmentsCurrent GI therapies

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01A.06Page 29GI manifestations of cystic fibrosisTreatmentsCFTR modulators — digestive effects?

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01A.06Page 30GI manifestations of cystic fibrosisClosing — quality of life

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01A.06Page 31GI manifestations of cystic fibrosisClosing

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01A.06Page 32GI manifestations of cystic fibrosisClosing

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01A.06Page 33GI manifestations of cystic fibrosisAppendix — multisystem disease diagram

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01A.06Page 34GI manifestations of cystic fibrosisAppendix — SBBO vicious cycle

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01A.06Page 35GI manifestations of cystic fibrosisAppendix — energy deficit summary

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