01A.07 · Mucoviscidose VII — transplantation pulmonaire

Cystic fibrosis VII — lung transplantation

Cas de liaison · 29 pages

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Lung transplantation

1Introduction and indications 2Growing impact of respiratory disease 3Inactivity, outcomes, and transplant criteria 4Absolute contraindications 5History and global volume 6Swiss waiting list and transplant numbers

CF as a transplant indication

7CF disease burden and multi-organ impact 8Main transplant diagnoses and CF pathophysiology 9CF survival trends and recipient age risk

Transplant timing and referral

10Finding the transplant window 11FEV1 decline as referral trigger 12CF transplant listing criteria 13Microbial risk factors in CF candidates

CFTR modulators and transplant need

14ETI phase 3 trial results 15ETI real-life impact on transplant pathway 16Decreased CF lung transplants — French data

Post-transplant risks and complications

17Surgical procedure and connections 18Early complications — imaging and drainage 19Airway anastomosis complications and stenosis 20Gastro-oesophageal reflux and rejection intro

Transplant immunology

21Allorecognition and T-cell effector pathways

Post-transplant management

22Infection risk and prophylaxis 23Immunosuppression side effects and follow-up

24Post-transplant survival by diagnosis

Post-transplant monitoring

25FEV1 trajectory and graft events timeline 26Acute rejection — clinical presentation 27Transbronchial biopsy and ISHLT rejection grading

Chronic allograft dysfunction (CLAD)

28CLAD definition — BOS and RAS patterns 29Pathophysiological model and conclusion

01A.07Page 1Lung transplantationIntroduction and indications

Mucoviscidose VII — transplantation pulmonaire page 1

01A.07Page 2Lung transplantationGrowing impact of respiratory disease

Mucoviscidose VII — transplantation pulmonaire page 2

01A.07Page 3Lung transplantationInactivity, outcomes, and transplant criteria

Mucoviscidose VII — transplantation pulmonaire page 3

01A.07Page 4Lung transplantationAbsolute contraindications

Mucoviscidose VII — transplantation pulmonaire page 4

01A.07Page 5Lung transplantationHistory and global volume

Mucoviscidose VII — transplantation pulmonaire page 5

01A.07Page 6Lung transplantationSwiss waiting list and transplant numbers

Mucoviscidose VII — transplantation pulmonaire page 6

01A.07Page 7Lung transplantationCF as a transplant indicationCF disease burden and multi-organ impact

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01A.07Page 8Lung transplantationCF as a transplant indicationMain transplant diagnoses and CF pathophysiology

Mucoviscidose VII — transplantation pulmonaire page 8

01A.07Page 9Lung transplantationCF as a transplant indicationCF survival trends and recipient age risk

Mucoviscidose VII — transplantation pulmonaire page 9

01A.07Page 10Lung transplantationTransplant timing and referralFinding the transplant window

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01A.07Page 11Lung transplantationTransplant timing and referralFEV1 decline as referral trigger

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01A.07Page 12Lung transplantationTransplant timing and referralCF transplant listing criteria

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01A.07Page 13Lung transplantationTransplant timing and referralMicrobial risk factors in CF candidates

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01A.07Page 14Lung transplantationCFTR modulators and transplant needETI phase 3 trial results

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01A.07Page 15Lung transplantationCFTR modulators and transplant needETI real-life impact on transplant pathway

Mucoviscidose VII — transplantation pulmonaire page 15

01A.07Page 16Lung transplantationCFTR modulators and transplant needDecreased CF lung transplants — French data

Mucoviscidose VII — transplantation pulmonaire page 16

01A.07Page 17Lung transplantationPost-transplant risks and complicationsSurgical procedure and connections

Mucoviscidose VII — transplantation pulmonaire page 17

01A.07Page 18Lung transplantationPost-transplant risks and complicationsEarly complications — imaging and drainage

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01A.07Page 19Lung transplantationPost-transplant risks and complicationsAirway anastomosis complications and stenosis

Mucoviscidose VII — transplantation pulmonaire page 19

01A.07Page 20Lung transplantationPost-transplant risks and complicationsGastro-oesophageal reflux and rejection intro

Mucoviscidose VII — transplantation pulmonaire page 20

01A.07Page 21Lung transplantationTransplant immunologyAllorecognition and T-cell effector pathways

Mucoviscidose VII — transplantation pulmonaire page 21

01A.07Page 22Lung transplantationPost-transplant managementInfection risk and prophylaxis

Mucoviscidose VII — transplantation pulmonaire page 22

01A.07Page 23Lung transplantationPost-transplant managementImmunosuppression side effects and follow-up

Mucoviscidose VII — transplantation pulmonaire page 23

01A.07Page 24Lung transplantationOutcomesPost-transplant survival by diagnosis

Mucoviscidose VII — transplantation pulmonaire page 24

01A.07Page 25Lung transplantationPost-transplant monitoringFEV1 trajectory and graft events timeline

Mucoviscidose VII — transplantation pulmonaire page 25

01A.07Page 26Lung transplantationPost-transplant monitoringAcute rejection — clinical presentation

Mucoviscidose VII — transplantation pulmonaire page 26

01A.07Page 27Lung transplantationPost-transplant monitoringTransbronchial biopsy and ISHLT rejection grading

Mucoviscidose VII — transplantation pulmonaire page 27

01A.07Page 28Lung transplantationChronic allograft dysfunction (CLAD)CLAD definition — BOS and RAS patterns

Mucoviscidose VII — transplantation pulmonaire page 28

01A.07Page 29Lung transplantationChronic allograft dysfunction (CLAD)Pathophysiological model and conclusion

Mucoviscidose VII — transplantation pulmonaire page 29