06A.01 · Structure de l'ADN

DNA structure

SMB1 De la molécule à la cellule De l'ADN à la protéine · 53 pages

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Course Objectives

2Course Objectives

Review Session Info

3Review Session Info

5Lecture Agenda

Purifying Heredity Chemically

6Purifying Heredity Chemically 7Mendel's Genetics Rules 8Chromosomes & Heredity 9Chromosomes in Cell Cycle 10Quiz: Chromosome Composition 11Nuclein to DNA 12Griffith's Transforming Principle 13Avery: DNA as Transformant 14Hershey & Chase Experiment

DNA Composition

15DNA Composition 16Nucleotide Structure 17Deoxyribose Sugar 18Purines & Pyrimidines 19Nucleotide Chain Polymer

DNA Structure & Properties

20DNA Structure & Properties 21Chargaff's Rules 22DNA Double Helix 23Structure Explains Function 24Hydrogen Bonds & Antiparallelism 25Antiparallel Strands 26Complementarity & Replication 27Break 28DNA Grooves 29Groove Recognition Patterns 30Protein–DNA Groove Contacts 31Quiz: Strand Separation 32Denaturation Principle 33Renaturation Specificity 34Alternative DNA Structures 35Guanine Tetrads

Human Genome Organization

36Human Genome Organization 37Chromosomes Overview 38DNA in Interphase Nucleus 40Mitotic Condensation 41Chromatin Composition 42Genome Organization Summary

Human Genome Sequencing

43Human Genome Sequencing 44Sequencing Strategies 45Human Genome Project Timeline 46Genome Annotations 47Sequencing Technology & Cost 48Gapless Genome (2022)

Genome Applications

49Genome Applications 50Disease Gene Discovery 51Clinical Sequencing Uses 52Structure Explains Function 53Genome Applications

06A.01Page 1DNA Structure

Structure de l'ADN page 1

06A.01Page 2Course Objectives

Structure de l'ADN page 2

06A.01Page 3Review Session Info

Structure de l'ADN page 3

06A.01Page 4Central Dogma

Structure de l'ADN page 4

06A.01Page 5Lecture Agenda

Structure de l'ADN page 5

06A.01Page 6Purifying Heredity Chemically

Structure de l'ADN page 6

06A.01Page 7Purifying Heredity ChemicallyMendel's Genetics Rules

Structure de l'ADN page 7

06A.01Page 8Purifying Heredity ChemicallyChromosomes & Heredity

Structure de l'ADN page 8

06A.01Page 9Purifying Heredity ChemicallyChromosomes in Cell Cycle

Structure de l'ADN page 9

06A.01Page 10Purifying Heredity ChemicallyQuiz: Chromosome Composition

Structure de l'ADN page 10

06A.01Page 11Purifying Heredity ChemicallyNuclein to DNA

Structure de l'ADN page 11

06A.01Page 12Purifying Heredity ChemicallyGriffith's Transforming Principle

Structure de l'ADN page 12

06A.01Page 13Purifying Heredity ChemicallyAvery: DNA as Transformant

Structure de l'ADN page 13

06A.01Page 14Purifying Heredity ChemicallyHershey & Chase Experiment

Structure de l'ADN page 14

06A.01Page 15DNA Composition

Structure de l'ADN page 15

06A.01Page 16DNA CompositionNucleotide Structure

Structure de l'ADN page 16

06A.01Page 17DNA CompositionDeoxyribose Sugar

Structure de l'ADN page 17

06A.01Page 18DNA CompositionPurines & Pyrimidines

Structure de l'ADN page 18

06A.01Page 19DNA CompositionNucleotide Chain Polymer

Structure de l'ADN page 19

06A.01Page 20DNA Structure & Properties

Structure de l'ADN page 20

06A.01Page 21DNA Structure & PropertiesChargaff's Rules

Structure de l'ADN page 21

06A.01Page 22DNA Structure & PropertiesDNA Double Helix

Structure de l'ADN page 22

06A.01Page 23DNA Structure & PropertiesStructure Explains Function

Structure de l'ADN page 23

06A.01Page 24DNA Structure & PropertiesHydrogen Bonds & Antiparallelism

Structure de l'ADN page 24

06A.01Page 25DNA Structure & PropertiesAntiparallel Strands

Structure de l'ADN page 25

06A.01Page 26DNA Structure & PropertiesComplementarity & Replication

Structure de l'ADN page 26

06A.01Page 27DNA Structure & PropertiesBreak

Structure de l'ADN page 27

06A.01Page 28DNA Structure & PropertiesDNA Grooves

Structure de l'ADN page 28

06A.01Page 29DNA Structure & PropertiesGroove Recognition Patterns

Structure de l'ADN page 29

06A.01Page 30DNA Structure & PropertiesProtein–DNA Groove Contacts

Structure de l'ADN page 30

06A.01Page 31DNA Structure & PropertiesQuiz: Strand Separation

Structure de l'ADN page 31

06A.01Page 32DNA Structure & PropertiesDenaturation Principle

Structure de l'ADN page 32

06A.01Page 33DNA Structure & PropertiesRenaturation Specificity

Structure de l'ADN page 33

06A.01Page 34DNA Structure & PropertiesAlternative DNA Structures

Structure de l'ADN page 34

06A.01Page 35DNA Structure & PropertiesGuanine Tetrads

Structure de l'ADN page 35

06A.01Page 36Human Genome Organization

Structure de l'ADN page 36

06A.01Page 37Human Genome OrganizationChromosomes Overview

Structure de l'ADN page 37

06A.01Page 38Human Genome OrganizationDNA in Interphase Nucleus

Structure de l'ADN page 38

06A.01Page 39Human Genome OrganizationDNA in Interphase Nucleus

Structure de l'ADN page 39

06A.01Page 40Human Genome OrganizationMitotic Condensation

Structure de l'ADN page 40

06A.01Page 41Human Genome OrganizationChromatin Composition

Structure de l'ADN page 41

06A.01Page 42Human Genome OrganizationGenome Organization Summary

Structure de l'ADN page 42

06A.01Page 43Human Genome Sequencing

Structure de l'ADN page 43

06A.01Page 44Human Genome SequencingSequencing Strategies

Structure de l'ADN page 44

06A.01Page 45Human Genome SequencingHuman Genome Project Timeline

Structure de l'ADN page 45

06A.01Page 46Human Genome SequencingGenome Annotations

Structure de l'ADN page 46

06A.01Page 47Human Genome SequencingSequencing Technology & Cost

Structure de l'ADN page 47

06A.01Page 48Human Genome SequencingGapless Genome (2022)

Structure de l'ADN page 48

06A.01Page 49Genome Applications

Structure de l'ADN page 49

06A.01Page 50Genome ApplicationsDisease Gene Discovery

Structure de l'ADN page 50

06A.01Page 51Genome ApplicationsClinical Sequencing Uses

Structure de l'ADN page 51

06A.01Page 52Genome ApplicationsStructure Explains Function

Structure de l'ADN page 52

06A.01Page 53Genome Applications

Structure de l'ADN page 53