09C.02 · Signalisation cellulaire II

Cell signaling II

Communication et tissus · 38 pages

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Cell signaling II

Intercellular Communications

1Lecture Introduction 2Signaling Vocabulary

3Cytoplasmic Receptors 4Paracrine Signaling: NO 5Membrane Receptor Overview 6Neurotransmitter Receptors Table

Ionotropic Receptors

7Channel Receptors: ACh Example 8Excitatory vs. Inhibitory

G Protein-Coupled Receptors

9GPCR Introduction 10GPCR Structure & Features 11GPCR Genome Distribution 12GPCR Classes A, B, C 13GPCR Ligands & Heterotrimeric G Protein 14GPCR Conformational Change 15Gα GDP/GTP Exchange

Second Messengers

16Adenylyl Cyclase / cAMP Pathway 17PKA Activation & Feedback 18cAMP → CREB → Gene Expression 19PLC-β / IP3 / DAG Pathway 20Calcium & Calmodulin

G Protein-Coupled Receptors

21Gβγ Signaling 22GPCR Activation Cycle 23Signal Termination & Desensitization 24G Protein States Summary 25GPCR Pathologies 26GPCR Example: Olfaction 27GPCR Example: Phototransduction

Enzyme-Linked Receptors

28Insulin Receptor Introduction 29RTK Family 30RTK Dimerization & Autophosphorylation 31RTK → PLC-γ Pathway 32Ras / Small GTPase Signaling 33GTPase Switch: GEF & GAP 34MAP Kinase Cascade

Gα12/13 / RhoA Pathway

35Gα12/13 → RhoA Mechanism 36Gα12/13 Tissue Examples

Signal Integration

37Pathway Convergence 38Signaling Network Complexity

09C.02Page 1Intercellular CommunicationsLecture Introduction

Signalisation cellulaire II page 1

09C.02Page 2Intercellular CommunicationsSignaling Vocabulary

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09C.02Page 3Receptor TypesCytoplasmic Receptors

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09C.02Page 4Receptor TypesParacrine Signaling: NO

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09C.02Page 5Receptor TypesMembrane Receptor Overview

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09C.02Page 6Receptor TypesNeurotransmitter Receptors Table

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09C.02Page 7Ionotropic ReceptorsChannel Receptors: ACh Example

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09C.02Page 8Ionotropic ReceptorsExcitatory vs. Inhibitory

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09C.02Page 9G Protein-Coupled ReceptorsGPCR Introduction

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09C.02Page 10G Protein-Coupled ReceptorsGPCR Structure & Features

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09C.02Page 11G Protein-Coupled ReceptorsGPCR Genome Distribution

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09C.02Page 12G Protein-Coupled ReceptorsGPCR Classes A, B, C

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09C.02Page 13G Protein-Coupled ReceptorsGPCR Ligands & Heterotrimeric G Protein

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09C.02Page 14G Protein-Coupled ReceptorsGPCR Conformational Change

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09C.02Page 15G Protein-Coupled ReceptorsGα GDP/GTP Exchange

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09C.02Page 16Second MessengersAdenylyl Cyclase / cAMP Pathway

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09C.02Page 17Second MessengersPKA Activation & Feedback

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09C.02Page 18Second MessengerscAMP → CREB → Gene Expression

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09C.02Page 19Second MessengersPLC-β / IP3 / DAG Pathway

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09C.02Page 20Second MessengersCalcium & Calmodulin

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09C.02Page 21G Protein-Coupled ReceptorsGβγ Signaling

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09C.02Page 22G Protein-Coupled ReceptorsGPCR Activation Cycle

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09C.02Page 23G Protein-Coupled ReceptorsSignal Termination & Desensitization

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09C.02Page 24G Protein-Coupled ReceptorsG Protein States Summary

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09C.02Page 25G Protein-Coupled ReceptorsGPCR Pathologies

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09C.02Page 26G Protein-Coupled ReceptorsGPCR Example: Olfaction

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09C.02Page 27G Protein-Coupled ReceptorsGPCR Example: Phototransduction

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09C.02Page 28Enzyme-Linked ReceptorsInsulin Receptor Introduction

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09C.02Page 29Enzyme-Linked ReceptorsRTK Family

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09C.02Page 30Enzyme-Linked ReceptorsRTK Dimerization & Autophosphorylation

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09C.02Page 31Enzyme-Linked ReceptorsRTK → PLC-γ Pathway

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09C.02Page 32Enzyme-Linked ReceptorsRas / Small GTPase Signaling

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09C.02Page 33Enzyme-Linked ReceptorsGTPase Switch: GEF & GAP

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09C.02Page 34Enzyme-Linked ReceptorsMAP Kinase Cascade

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09C.02Page 35Gα12/13 / RhoA PathwayGα12/13 → RhoA Mechanism

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09C.02Page 36Gα12/13 / RhoA PathwayGα12/13 Tissue Examples

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09C.02Page 37Signal IntegrationPathway Convergence

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09C.02Page 38Signal IntegrationSignaling Network Complexity

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