09C.03 · Molécules d’adhésion cellulaire

Cell adhesion molecules

Communication et tissus · 75 pages

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Cell adhesion molecules

Course Overview

2Course Overview 3Schematic Map

Course Logistics

4Course Logistics

Indirect Communication

5Indirect Communication

Direct Communication

6Direct Communication

Prototypical Organization

8Receptor-Adaptor-Cytoskeleton 9Historical: Mouse Compaction 10Junction Types Overview

Claudins / Tight Junctions

31Family Overview 32Tight Junction Structure 33Claudin Band Assembly 34Paracellular Pores 35Sealing Belt Around Cells 36Membrane Compartmentalization 37Apical vs Basolateral Domain 38Membrane Polarity Maintenance 39Intercellular Space Closure 40Tight Junction Rupture: Jaundice

Connexins / Gap Junctions

41Family Overview 42Connexin Structure 43Connexon & Channel Assembly 44Tight vs Gap Junction Comparison 45Gap Junction Channels 46Electrical & Metabolic Coupling 47Coupling Spreads Cell-to-Cell 48Connexin Mutations & Disease

49Family Overview 50Leukocyte–Endothelium Adhesion

51Family Overview 52Immunoglobulin Domain Structure

Cell-Cell Receptors Summary

53Cell-Cell Receptors Summary

Cell-Cell Adhesion Overview

54Cell-Cell Adhesion Overview

Cell-Matrix Adhesion Overview

55Cell-Matrix Adhesion Overview

56Historical: Gastrulation & ECM 57Family Overview 58Integrin Structure Overview 59α and β Chains 60Ligand Specificity by α/β Pairing 61Allosteric Regulation: Inside-Out 62Allosteric Regulation: ECM Binding 63Tension Stabilization 64Focal Adhesions 65Focal Adhesion Migration Dynamics 66α6β4: Intermediate Filament Link 67β-Catenin / Wnt Signaling 68Hemidesmosomes: Cell Polarity 69Inter-Tissue Adhesion 70Hemidesmosome System 71α6β4 Loss: Skin Blisters 72Integrin Defect Pathologies

Summary: All Junctions

73Epithelial Cell Diagram 74Molecular Details Table

09C.03Page 1Title Slide

Molécules d’adhésion cellulaire page 1

09C.03Page 2Course Overview

Molécules d’adhésion cellulaire page 2

09C.03Page 3Course OverviewSchematic Map

Molécules d’adhésion cellulaire page 3

09C.03Page 4Course Logistics

Molécules d’adhésion cellulaire page 4

09C.03Page 5Indirect Communication

Molécules d’adhésion cellulaire page 5

09C.03Page 6Direct Communication

Molécules d’adhésion cellulaire page 6

09C.03Page 7Course Agenda

Molécules d’adhésion cellulaire page 7

09C.03Page 8Prototypical OrganizationReceptor-Adaptor-Cytoskeleton

Molécules d’adhésion cellulaire page 8

09C.03Page 9Prototypical OrganizationHistorical: Mouse Compaction

Molécules d’adhésion cellulaire page 9

09C.03Page 10Prototypical OrganizationJunction Types Overview

Molécules d’adhésion cellulaire page 10

09C.03Page 11CadherinsFamily Overview

Molécules d’adhésion cellulaire page 11

09C.03Page 12CadherinsMolecular Structure

Molécules d’adhésion cellulaire page 12

09C.03Page 13CadherinsHomotypic Domain Swapping

Molécules d’adhésion cellulaire page 13

09C.03Page 14CadherinsCa²⁺ Stabilizes Structure

Molécules d’adhésion cellulaire page 14

09C.03Page 15CadherinsTrans- and Cis-Dimers

Molécules d’adhésion cellulaire page 15

09C.03Page 16CadherinsCa²⁺ Dependence (Imaging)

Molécules d’adhésion cellulaire page 16

09C.03Page 17CadherinsCa²⁺ Dependence (Video)

Molécules d’adhésion cellulaire page 17

09C.03Page 18CadherinsFunction: Cell Shape

Molécules d’adhésion cellulaire page 18

09C.03Page 19CadherinsCadherin–Actin Co-localization

Molécules d’adhésion cellulaire page 19

09C.03Page 20CadherinsCadherin/Catenin Complex

Molécules d’adhésion cellulaire page 20

09C.03Page 21CadherinsTension Reinforces Linkage

Molécules d’adhésion cellulaire page 21

09C.03Page 22CadherinsAdherens Junction Structure

Molécules d’adhésion cellulaire page 22

09C.03Page 23CadherinsJunctions Enable Tissue Movements

Molécules d’adhésion cellulaire page 23

09C.03Page 24CadherinsAJ-Driven Tissue Remodeling

Molécules d’adhésion cellulaire page 24

09C.03Page 25CadherinsDesmosome Structure

Molécules d’adhésion cellulaire page 25

09C.03Page 26CadherinsDesmosomes: IF Anchoring

Molécules d’adhésion cellulaire page 26

09C.03Page 27CadherinsAJ vs Desmosome Adaptors

Molécules d’adhésion cellulaire page 27

09C.03Page 28CadherinsDesmosomes in Stratified Epithelium

Molécules d’adhésion cellulaire page 28

09C.03Page 29CadherinsDesmosome Deficiency: Pemphigus

Molécules d’adhésion cellulaire page 29

09C.03Page 30CadherinsDesmosome Failure: Skin Lesions

Molécules d’adhésion cellulaire page 30

09C.03Page 31Claudins / Tight JunctionsFamily Overview

Molécules d’adhésion cellulaire page 31

09C.03Page 32Claudins / Tight JunctionsTight Junction Structure

Molécules d’adhésion cellulaire page 32

09C.03Page 33Claudins / Tight JunctionsClaudin Band Assembly

Molécules d’adhésion cellulaire page 33

09C.03Page 34Claudins / Tight JunctionsParacellular Pores

Molécules d’adhésion cellulaire page 34

09C.03Page 35Claudins / Tight JunctionsSealing Belt Around Cells

Molécules d’adhésion cellulaire page 35

09C.03Page 36Claudins / Tight JunctionsMembrane Compartmentalization

Molécules d’adhésion cellulaire page 36

09C.03Page 37Claudins / Tight JunctionsApical vs Basolateral Domain

Molécules d’adhésion cellulaire page 37

09C.03Page 38Claudins / Tight JunctionsMembrane Polarity Maintenance

Molécules d’adhésion cellulaire page 38

09C.03Page 39Claudins / Tight JunctionsIntercellular Space Closure

Molécules d’adhésion cellulaire page 39

09C.03Page 40Claudins / Tight JunctionsTight Junction Rupture: Jaundice

Molécules d’adhésion cellulaire page 40

09C.03Page 41Connexins / Gap JunctionsFamily Overview

Molécules d’adhésion cellulaire page 41

09C.03Page 42Connexins / Gap JunctionsConnexin Structure

Molécules d’adhésion cellulaire page 42

09C.03Page 43Connexins / Gap JunctionsConnexon & Channel Assembly

Molécules d’adhésion cellulaire page 43

09C.03Page 44Connexins / Gap JunctionsTight vs Gap Junction Comparison

Molécules d’adhésion cellulaire page 44

09C.03Page 45Connexins / Gap JunctionsGap Junction Channels

Molécules d’adhésion cellulaire page 45

09C.03Page 46Connexins / Gap JunctionsElectrical & Metabolic Coupling

Molécules d’adhésion cellulaire page 46

09C.03Page 47Connexins / Gap JunctionsCoupling Spreads Cell-to-Cell

Molécules d’adhésion cellulaire page 47

09C.03Page 48Connexins / Gap JunctionsConnexin Mutations & Disease

Molécules d’adhésion cellulaire page 48

09C.03Page 49SelectinsFamily Overview

Molécules d’adhésion cellulaire page 49

09C.03Page 50SelectinsLeukocyte–Endothelium Adhesion

Molécules d’adhésion cellulaire page 50

09C.03Page 51CAMsFamily Overview

Molécules d’adhésion cellulaire page 51

09C.03Page 52CAMsImmunoglobulin Domain Structure

Molécules d’adhésion cellulaire page 52

09C.03Page 53Cell-Cell Receptors Summary

Molécules d’adhésion cellulaire page 53

09C.03Page 54Cell-Cell Adhesion Overview

Molécules d’adhésion cellulaire page 54

09C.03Page 55Cell-Matrix Adhesion Overview

Molécules d’adhésion cellulaire page 55

09C.03Page 56IntegrinsHistorical: Gastrulation & ECM

Molécules d’adhésion cellulaire page 56

09C.03Page 57IntegrinsFamily Overview

Molécules d’adhésion cellulaire page 57

09C.03Page 58IntegrinsIntegrin Structure Overview

Molécules d’adhésion cellulaire page 58

09C.03Page 59Integrinsα and β Chains

Molécules d’adhésion cellulaire page 59

09C.03Page 60IntegrinsLigand Specificity by α/β Pairing

Molécules d’adhésion cellulaire page 60

09C.03Page 61IntegrinsAllosteric Regulation: Inside-Out

Molécules d’adhésion cellulaire page 61

09C.03Page 62IntegrinsAllosteric Regulation: ECM Binding

Molécules d’adhésion cellulaire page 62

09C.03Page 63IntegrinsTension Stabilization

Molécules d’adhésion cellulaire page 63

09C.03Page 64IntegrinsFocal Adhesions

Molécules d’adhésion cellulaire page 64

09C.03Page 65IntegrinsFocal Adhesion Migration Dynamics

Molécules d’adhésion cellulaire page 65

09C.03Page 66Integrinsα6β4: Intermediate Filament Link

Molécules d’adhésion cellulaire page 66

09C.03Page 67Integrinsβ-Catenin / Wnt Signaling

Molécules d’adhésion cellulaire page 67

09C.03Page 68IntegrinsHemidesmosomes: Cell Polarity

Molécules d’adhésion cellulaire page 68

09C.03Page 69IntegrinsInter-Tissue Adhesion

Molécules d’adhésion cellulaire page 69

09C.03Page 70IntegrinsHemidesmosome System

Molécules d’adhésion cellulaire page 70

09C.03Page 71Integrinsα6β4 Loss: Skin Blisters

Molécules d’adhésion cellulaire page 71

09C.03Page 72IntegrinsIntegrin Defect Pathologies

Molécules d’adhésion cellulaire page 72

09C.03Page 73Summary: All JunctionsEpithelial Cell Diagram

Molécules d’adhésion cellulaire page 73

09C.03Page 74Summary: All JunctionsMolecular Details Table

Molécules d’adhésion cellulaire page 74

09C.03Page 75Blank Slide

Molécules d’adhésion cellulaire page 75