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10 · SMB3 · Cardio, respi & rénal · 10A.90 · Circulatoire — polycopié 2020 · all pages
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10A.90 · Circulatoire — polycopié 2020

Circulatory system — 2020 handout

Système circulatoire · 69 pages

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1Title Page2Table of Contents
Introduction
3Need for a Circulatory System
1. Overview of the Circulatory System
4Three Subsystems: Blood, Heart, Vessels5Heart Pump Phases and Vessel Types6Blood Volume Distribution7Parallel and Series Vascular Arrangement8Systemic and Pulmonary Circuits9Pressure Profile and Mean Circulatory Pressure10Cross-Sectional Area and Blood Velocity11Organ Blood Flow Distribution12Cardiac Output at Rest vs Exercise13Lymphatic System Overview
2. Blood
14Composition: Plasma and Cells15Blood Cell Types and Erythrocytes16Iron Recycling and Erythrocyte Lifecycle17Erythropoietin (EPO) Regulation18Anemia and Polycythemia
3. Heart
19Double Pump in Series20Cardiac Output and Valve Function21Functional Anatomy and Ventricular Filling22Isovolumic Contraction and Ejection23Cardiac Cycle Pressure and Volume Timing24Pressure-Volume Loop and Preload25Starling's Law: Tension-Length Relationship26Cardiac Muscle Ultrastructure27Afterload and Wall Tension28Afterload, Contractility, and Stroke Volume29Excitation-Contraction Coupling: Ca²⁺ Release30Excitation-Contraction Coupling: Mechanism31Determinants of Cardiac Output
4. Vessels
32Arteries: Elasticity and Pulse Smoothing33Windkessel Effect and Pulse Pressure34Mean Arterial Pressure Formula35Arterioles: Resistance and Poiseuille's Law36Arteriolar Radius Control and Capillary Exchange37Starling Forces: Filtration and Absorption38Starling Equation: Jv and Filtration Coefficient39Net Filtration Pressure: Arterial vs Venous End40Venous Pressures and Central Venous Pressure41Peripheral vs Central Venous Pressure42Venous Return: Muscle and Respiratory Pumps43Venous Return Mechanics and Valve Incompetence44Lymphatic System: Protein Recovery45Lymph Flow, Edema, and Fat Transport
5. Biophysics of Blood Circulation
46Velocity/Area and Pascal's Law47Bernoulli's Law: Pressure and Velocity48Viscous Blood and Aortic Stenosis Example49Poiseuille's Law and Vascular Resistance50Parallel Resistance and Turbulent Flow51Vascular Distensibility and Compliance52Pressure-Volume Curves and Sympathetic Effects53Blood Redistribution During Pressure Drop
6. Heart-Vessel Integration
54Cardiac Function Curve55Vascular Function Curve56Simplified Two-Compartment Model57Volume and Resistance Shifts on Vascular Curve58Equilibrium Point: Heart-Vessel Coupling59Sympathetic Stimulation Shifts Equilibrium
7. Arterial Pressure Regulation
60Hemorrhage and Pressure Recovery61Baroreceptor Reflex After Hemorrhage62Volume Correction and Positive Feedback Risk63Hypertension: Causes and Consequences64Baroreceptor Reflex Summary Diagram
8. Heart Failure
65Definition and Causes66Systolic vs Diastolic Dysfunction67Compensatory Mechanisms and Vicious Circle68Untreated vs Treated Heart Failure Outcome69Heart Failure Vicious Circle (cont.)