10B.04 · Transport des gaz sanguins

Blood gas transport

Système respiratoire · 42 pages

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Blood gas transport

Blood Gas Transport

1Blood Gas Transport 2Objectives 3Cardiorespiratory Pathway Overview

Blood as Gas Transport Organ

4Dissolved vs Hb-Bound Forms 5Dissolved Fraction and Partial Pressure 6O2 vs CO2 Solubility

Hemoglobin and O2 Dissociation

7Hemoglobin Structure and Gas Affinity 8Dissociation Curve and P50 9Arterial O2 Content Formula 10Dissolved vs Combined O2 Content 11Hb Concentration and O2 Content 12CaO2 at Different Hb Levels 13Sigmoid Shape: Allosteric Cooperativity 14Sigmoid Advantage: Loading and Unloading

Oxygen Pathway and Delivery

15Convective O2 Transport 16PO2 Drop Along the Pathway 17O2 Cascade and Diffusion Distance 18Tissue PO2 by Organ

Factors Modifying Hb Affinity

19Curve Shifts: pH, DPG, Temperature 20Temperature Effect: Baseline Calculation 21Temperature Effect: Reduced CaO2 22Summary of Affinity Modulators

23Three Forms of CO2 in Blood 24Acid-Base Balance and Henderson-Hasselbalch 25RBC CO2-Bicarbonate Exchange

Bohr and Haldane Effects

26Bohr Effect: CO2 Shifts O2 Curve 27Haldane Effect: PaO2 Modulates CO2 Carriage 28Haldane Effect: Molecular Mechanism 29Bohr and Haldane Combined Summary 30Tissue vs Lung Integration

Respiratory Quotient

31Cell Substrate and Metabolic Notation 32RQ Definition: VCO2 / VO2 33Carbohydrate vs Lipid RQ 34RQ During Exercise 35O2 vs CO2 Dissociation Curve Comparison

O2 Consumption and Exercise

36VO2 Determinants 37Fick Principle 38Fick Calculation: VO2 at Rest 39O2 Delivery During Exercise 40Pulmonary O2 Diffusion at Rest 41Pulmonary O2 Diffusion During Exercise

Blood Gas Transport

10B.04Page 1Blood Gas Transport

Transport des gaz sanguins page 1

10B.04Page 2Blood Gas TransportObjectives

Transport des gaz sanguins page 2

10B.04Page 3Blood Gas TransportCardiorespiratory Pathway Overview

Transport des gaz sanguins page 3

10B.04Page 4Blood as Gas Transport OrganDissolved vs Hb-Bound Forms

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10B.04Page 5Blood as Gas Transport OrganDissolved Fraction and Partial Pressure

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10B.04Page 6Blood as Gas Transport OrganO2 vs CO2 Solubility

Transport des gaz sanguins page 6

10B.04Page 7Hemoglobin and O2 DissociationHemoglobin Structure and Gas Affinity

Transport des gaz sanguins page 7

10B.04Page 8Hemoglobin and O2 DissociationDissociation Curve and P50

Transport des gaz sanguins page 8

10B.04Page 9Hemoglobin and O2 DissociationArterial O2 Content Formula

Transport des gaz sanguins page 9

10B.04Page 10Hemoglobin and O2 DissociationDissolved vs Combined O2 Content

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10B.04Page 11Hemoglobin and O2 DissociationHb Concentration and O2 Content

Transport des gaz sanguins page 11

10B.04Page 12Hemoglobin and O2 DissociationCaO2 at Different Hb Levels

Transport des gaz sanguins page 12

10B.04Page 13Hemoglobin and O2 DissociationSigmoid Shape: Allosteric Cooperativity

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10B.04Page 14Hemoglobin and O2 DissociationSigmoid Advantage: Loading and Unloading

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10B.04Page 15Oxygen Pathway and DeliveryConvective O2 Transport

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10B.04Page 16Oxygen Pathway and DeliveryPO2 Drop Along the Pathway

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10B.04Page 17Oxygen Pathway and DeliveryO2 Cascade and Diffusion Distance

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10B.04Page 18Oxygen Pathway and DeliveryTissue PO2 by Organ

Transport des gaz sanguins page 18

10B.04Page 19Factors Modifying Hb AffinityCurve Shifts: pH, DPG, Temperature

Transport des gaz sanguins page 19

10B.04Page 20Factors Modifying Hb AffinityTemperature Effect: Baseline Calculation

Transport des gaz sanguins page 20

10B.04Page 21Factors Modifying Hb AffinityTemperature Effect: Reduced CaO2

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10B.04Page 22Factors Modifying Hb AffinitySummary of Affinity Modulators

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10B.04Page 23CO2 TransportThree Forms of CO2 in Blood

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10B.04Page 24CO2 TransportAcid-Base Balance and Henderson-Hasselbalch

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10B.04Page 25CO2 TransportRBC CO2-Bicarbonate Exchange

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10B.04Page 26Bohr and Haldane EffectsBohr Effect: CO2 Shifts O2 Curve

Transport des gaz sanguins page 26

10B.04Page 27Bohr and Haldane EffectsHaldane Effect: PaO2 Modulates CO2 Carriage

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10B.04Page 28Bohr and Haldane EffectsHaldane Effect: Molecular Mechanism

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10B.04Page 29Bohr and Haldane EffectsBohr and Haldane Combined Summary

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10B.04Page 30Bohr and Haldane EffectsTissue vs Lung Integration

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10B.04Page 31Respiratory QuotientCell Substrate and Metabolic Notation

Transport des gaz sanguins page 31

10B.04Page 32Respiratory QuotientRQ Definition: VCO2 / VO2

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10B.04Page 33Respiratory QuotientCarbohydrate vs Lipid RQ

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10B.04Page 34Respiratory QuotientRQ During Exercise

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10B.04Page 35Respiratory QuotientO2 vs CO2 Dissociation Curve Comparison

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10B.04Page 36O2 Consumption and ExerciseVO2 Determinants

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10B.04Page 37O2 Consumption and ExerciseFick Principle

Transport des gaz sanguins page 37

10B.04Page 38O2 Consumption and ExerciseFick Calculation: VO2 at Rest

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10B.04Page 39O2 Consumption and ExerciseO2 Delivery During Exercise

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10B.04Page 40O2 Consumption and ExercisePulmonary O2 Diffusion at Rest

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10B.04Page 41O2 Consumption and ExercisePulmonary O2 Diffusion During Exercise

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10B.04Page 42Blood Gas TransportKey Messages

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