11C.04 · Physiologie reproductive féminine

Female reproductive physiology

Système reproducteur · 57 pages

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Learning Objectives

2Learning Objectives

Course Integration

3Course Integration

Lecture Outline

4Lecture Outline

5Anatomy Review

Menstrual Cycle Overview

6Menstrual Cycle Overview

I. Ovary & Follicular Development

7I. Ovary & Follicular Development 8Ovarian Histology 9Ovarian Changes Across Life

Ia. Follicular Development

10Follicle Stage Sequence

Ia. Follicular Development

11Ia. Follicular Development 12Follicle Structure Diagram 13Antral Secondary Follicle 14Pre-Graafian Follicle 15Follicles: Imaging vs Histology 16Recruitment to Dominance 17Follicular Cell Expansion 18Mitosis in Antral Follicle

19HPG Axis Overview

Ia. Follicular Development

20FSH-Driven Selection

21Steroid Synthesis Pathway 22Follicular Steroidogenesis

Two-Cell Steroid Model

23Two-Cell Steroid Model 24Theca-Granulosa Compartments 25Estradiol Synthesis 26Follicular Estradiol Secretion

27Estradiol Actions

Two-Cell Steroid Model

28Steroid Synthesis Diagram

29Estrogen Feedback Control 30Estrogen Feedback → LH Surge

31LH Surge Effects

32Ib. Ovulation

Ic. Corpus Luteum Formation

33Ic. Corpus Luteum Formation 35Corpus Luteum Cell Types 36Basal Lamina Rupture & Angiogenesis 37Post-Ovulation Reorganization 38Before Ovulation: Steroidogenesis 39After Ovulation: Steroidogenesis 40Corpus Luteum Hormones 41Two-Cell Model Post-Ovulation 42Progesterone & Estradiol Output 43Corpus Luteum Summary

44Progesterone Actions 45Progesterone Feedback Control 46Corpus Luteum Lifespan 47hCG & Corpus Luteum Rescue 48FSH & LH Synthesis Exercise

II. Uterus & Menstrual Cycle

49II. Uterus & Menstrual Cycle 50Uterine Epithelium 51Ovarian-Uterine Cycle Summary 52Proliferative Phase 53Secretory Phase 54Menstruation 55Menstruation & Endometriosis

56Post-Pubertal vs Menopausal Ovary

57Follicle Depletion & Gonadotropin Rise

11C.04Page 1Title Slide

Physiologie reproductive féminine page 1

11C.04Page 2Learning Objectives

Physiologie reproductive féminine page 2

11C.04Page 3Course Integration

Physiologie reproductive féminine page 3

11C.04Page 4Lecture Outline

Physiologie reproductive féminine page 4

11C.04Page 5Anatomy Review

Physiologie reproductive féminine page 5

11C.04Page 6Menstrual Cycle Overview

Physiologie reproductive féminine page 6

11C.04Page 7I. Ovary & Follicular Development

Physiologie reproductive féminine page 7

11C.04Page 8I. Ovary & Follicular DevelopmentOvarian Histology

Physiologie reproductive féminine page 8

11C.04Page 9I. Ovary & Follicular DevelopmentOvarian Changes Across Life

Physiologie reproductive féminine page 9

11C.04Page 10I. Ovary & Follicular DevelopmentIa. Follicular DevelopmentFollicle Stage Sequence

Physiologie reproductive féminine page 10

11C.04Page 11I. Ovary & Follicular DevelopmentIa. Follicular Development

Physiologie reproductive féminine page 11

11C.04Page 12I. Ovary & Follicular DevelopmentIa. Follicular DevelopmentFollicle Structure Diagram

Physiologie reproductive féminine page 12

11C.04Page 13I. Ovary & Follicular DevelopmentIa. Follicular DevelopmentAntral Secondary Follicle

Physiologie reproductive féminine page 13

11C.04Page 14I. Ovary & Follicular DevelopmentIa. Follicular DevelopmentPre-Graafian Follicle

Physiologie reproductive féminine page 14

11C.04Page 15I. Ovary & Follicular DevelopmentIa. Follicular DevelopmentFollicles: Imaging vs Histology

Physiologie reproductive féminine page 15

11C.04Page 16I. Ovary & Follicular DevelopmentIa. Follicular DevelopmentRecruitment to Dominance

Physiologie reproductive féminine page 16

11C.04Page 17I. Ovary & Follicular DevelopmentIa. Follicular DevelopmentFollicular Cell Expansion

Physiologie reproductive féminine page 17

11C.04Page 18I. Ovary & Follicular DevelopmentIa. Follicular DevelopmentMitosis in Antral Follicle

Physiologie reproductive féminine page 18

11C.04Page 19I. Ovary & Follicular DevelopmentHPG Axis Overview

Physiologie reproductive féminine page 19

11C.04Page 20I. Ovary & Follicular DevelopmentIa. Follicular DevelopmentFSH-Driven Selection

Physiologie reproductive féminine page 20

11C.04Page 21I. Ovary & Follicular DevelopmentSteroid Synthesis Pathway

Physiologie reproductive féminine page 21

11C.04Page 22I. Ovary & Follicular DevelopmentFollicular Steroidogenesis

Physiologie reproductive féminine page 22

11C.04Page 23I. Ovary & Follicular DevelopmentTwo-Cell Steroid Model

Physiologie reproductive féminine page 23

11C.04Page 24I. Ovary & Follicular DevelopmentTwo-Cell Steroid ModelTheca-Granulosa Compartments

Physiologie reproductive féminine page 24

11C.04Page 25I. Ovary & Follicular DevelopmentTwo-Cell Steroid ModelEstradiol Synthesis

Physiologie reproductive féminine page 25

11C.04Page 26I. Ovary & Follicular DevelopmentTwo-Cell Steroid ModelFollicular Estradiol Secretion

Physiologie reproductive féminine page 26

11C.04Page 27I. Ovary & Follicular DevelopmentEstradiol Actions

Physiologie reproductive féminine page 27

11C.04Page 28I. Ovary & Follicular DevelopmentTwo-Cell Steroid ModelSteroid Synthesis Diagram

Physiologie reproductive féminine page 28

11C.04Page 29I. Ovary & Follicular DevelopmentEstrogen Feedback Control

Physiologie reproductive féminine page 29

11C.04Page 30I. Ovary & Follicular DevelopmentEstrogen Feedback → LH Surge

Physiologie reproductive féminine page 30

11C.04Page 31I. Ovary & Follicular DevelopmentIb. OvulationLH Surge Effects

Physiologie reproductive féminine page 31

11C.04Page 32I. Ovary & Follicular DevelopmentIb. Ovulation

Physiologie reproductive féminine page 32

11C.04Page 33I. Ovary & Follicular DevelopmentIc. Corpus Luteum Formation

Physiologie reproductive féminine page 33

11C.04Page 34I. Ovary & Follicular DevelopmentIc. Corpus Luteum Formation

Physiologie reproductive féminine page 34

11C.04Page 35I. Ovary & Follicular DevelopmentIc. Corpus Luteum FormationCorpus Luteum Cell Types

Physiologie reproductive féminine page 35

11C.04Page 36I. Ovary & Follicular DevelopmentIc. Corpus Luteum FormationBasal Lamina Rupture & Angiogenesis

Physiologie reproductive féminine page 36

11C.04Page 37I. Ovary & Follicular DevelopmentIc. Corpus Luteum FormationPost-Ovulation Reorganization

Physiologie reproductive féminine page 37

11C.04Page 38I. Ovary & Follicular DevelopmentIc. Corpus Luteum FormationBefore Ovulation: Steroidogenesis

Physiologie reproductive féminine page 38

11C.04Page 39I. Ovary & Follicular DevelopmentIc. Corpus Luteum FormationAfter Ovulation: Steroidogenesis

Physiologie reproductive féminine page 39

11C.04Page 40I. Ovary & Follicular DevelopmentIc. Corpus Luteum FormationCorpus Luteum Hormones

Physiologie reproductive féminine page 40

11C.04Page 41I. Ovary & Follicular DevelopmentIc. Corpus Luteum FormationTwo-Cell Model Post-Ovulation

Physiologie reproductive féminine page 41

11C.04Page 42I. Ovary & Follicular DevelopmentIc. Corpus Luteum FormationProgesterone & Estradiol Output

Physiologie reproductive féminine page 42

11C.04Page 43I. Ovary & Follicular DevelopmentIc. Corpus Luteum FormationCorpus Luteum Summary

Physiologie reproductive féminine page 43

11C.04Page 44I. Ovary & Follicular DevelopmentProgesterone Actions

Physiologie reproductive féminine page 44

11C.04Page 45I. Ovary & Follicular DevelopmentProgesterone Feedback Control

Physiologie reproductive féminine page 45

11C.04Page 46I. Ovary & Follicular DevelopmentCorpus Luteum Lifespan

Physiologie reproductive féminine page 46

11C.04Page 47I. Ovary & Follicular DevelopmenthCG & Corpus Luteum Rescue

Physiologie reproductive féminine page 47

11C.04Page 48I. Ovary & Follicular DevelopmentFSH & LH Synthesis Exercise

Physiologie reproductive féminine page 48

11C.04Page 49II. Uterus & Menstrual Cycle

Physiologie reproductive féminine page 49

11C.04Page 50II. Uterus & Menstrual CycleUterine Epithelium

Physiologie reproductive féminine page 50

11C.04Page 51II. Uterus & Menstrual CycleOvarian-Uterine Cycle Summary

Physiologie reproductive féminine page 51

11C.04Page 52II. Uterus & Menstrual CycleProliferative Phase

Physiologie reproductive féminine page 52

11C.04Page 53II. Uterus & Menstrual CycleSecretory Phase

Physiologie reproductive féminine page 53

11C.04Page 54II. Uterus & Menstrual CycleMenstruation

Physiologie reproductive féminine page 54

11C.04Page 55II. Uterus & Menstrual CycleMenstruation & Endometriosis

Physiologie reproductive féminine page 55

11C.04Page 56Ovarian AgingPost-Pubertal vs Menopausal Ovary

Physiologie reproductive féminine page 56

11C.04Page 57MenopauseFollicle Depletion & Gonadotropin Rise

Physiologie reproductive féminine page 57