11C.05 · Hormones sexuelles

Sex hormones

Système reproducteur · 70 pages

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2Hormone Basics

Liposoluble vs Hydrosoluble

3Liposoluble vs Hydrosoluble

Sex Hormones: Definition

4Sex Hormones: Definition

Sexual Endocrine Axis

5Sexual Endocrine Axis

Key Hormones Overview

6Key Hormones Overview

Steroid Synthesis

7Steroidogenesis Overview 8Sex Steroid Families 9Cholesterol Pathway

Steroid Transport

10Albumin & Binding Proteins 11SHBG & CBG Affinities 12SHBG Concentration Effects

Steroid Mechanism of Action

13Genomic Action 14Receptor Domains 15Genomic Mechanism Steps 16Receptor Model (Info)17Agonists & Antagonists 18Non-Genomic Action

Steroidogenesis Regulation

19Two-Cell Model: Ovary & Testis 20Ovarian Follicle Two-Cell

Sex Hormones: Roles Intro

21Sex Hormones: Roles Intro

22Section Outline 23Structure & Production 24Menstrual Cycle Context 25Transport & Regulation 26Luteal Axis Diagram 27Main Roles 28Cycle Levels Graph 29Endometrial Changes

30Section Outline 31Structure & Aromatase 32Transport & Regulation 33Estrogen Feedback Diagram 34Full Cycle Overview 35Main Roles 36Estradiol Cycle Levels 37Endometrial Growth & LH Peak 38Female Puberty Changes 39Role in Spermatogenesis 40Cycle Summary

41Section Outline 42Structure & Production 43Transport, Regulation & AR 44HPT Axis Diagram 45Main Roles 46Anabolic vs Other Effects 47Fetal Sexual Differentiation 48Male Phenotype Summary 49Brain Imprinting 50Testicular Descent 51Male Secondary Characteristics 52Male Puberty Timeline 53Ovarian Follicular Role 54Female Androgen Excess 55Male Hypogonadism

Steroid Measurement

56Cycle Graph Scale Caution 57Anabolic Steroids Context 58Dosage Introduction 59Measurement Challenge: Concentration 60Measurement Challenge: Structural Similarity 61RIA: Historical Context 62RIA Principle 63GC-MS Method Overview 64GC-MS: Injection Step 65GC-MS: Retention Time & Detection 66GC-MS / LC-MS Summary 67Normal Cycle Reference Values 68Free Fraction Measurement

70Abbreviations

11C.05Page 1Title Slide

Hormones sexuelles page 1

11C.05Page 2Hormone Basics

Hormones sexuelles page 2

11C.05Page 3Liposoluble vs Hydrosoluble

Hormones sexuelles page 3

11C.05Page 4Sex Hormones: Definition

Hormones sexuelles page 4

11C.05Page 5Sexual Endocrine Axis

Hormones sexuelles page 5

11C.05Page 6Key Hormones Overview

Hormones sexuelles page 6

11C.05Page 7Steroid SynthesisSteroidogenesis Overview

Hormones sexuelles page 7

11C.05Page 8Steroid SynthesisSex Steroid Families

Hormones sexuelles page 8

11C.05Page 9Steroid SynthesisCholesterol Pathway

Hormones sexuelles page 9

11C.05Page 10Steroid TransportAlbumin & Binding Proteins

Hormones sexuelles page 10

11C.05Page 11Steroid TransportSHBG & CBG Affinities

Hormones sexuelles page 11

11C.05Page 12Steroid TransportSHBG Concentration Effects

Hormones sexuelles page 12

11C.05Page 13Steroid Mechanism of ActionGenomic Action

Hormones sexuelles page 13

11C.05Page 14Steroid Mechanism of ActionReceptor Domains

Hormones sexuelles page 14

11C.05Page 15Steroid Mechanism of ActionGenomic Mechanism Steps

Hormones sexuelles page 15

11C.05Page 16Steroid Mechanism of ActionReceptor Model (Info)

Hormones sexuelles page 16

11C.05Page 17Steroid Mechanism of ActionAgonists & Antagonists

Hormones sexuelles page 17

11C.05Page 18Steroid Mechanism of ActionNon-Genomic Action

Hormones sexuelles page 18

11C.05Page 19Steroidogenesis RegulationTwo-Cell Model: Ovary & Testis

Hormones sexuelles page 19

11C.05Page 20Steroidogenesis RegulationOvarian Follicle Two-Cell

Hormones sexuelles page 20

11C.05Page 21Sex Hormones: Roles Intro

Hormones sexuelles page 21

11C.05Page 22ProgesteroneSection Outline

Hormones sexuelles page 22

11C.05Page 23ProgesteroneStructure & Production

Hormones sexuelles page 23

11C.05Page 24ProgesteroneMenstrual Cycle Context

Hormones sexuelles page 24

11C.05Page 25ProgesteroneTransport & Regulation

Hormones sexuelles page 25

11C.05Page 26ProgesteroneLuteal Axis Diagram

Hormones sexuelles page 26

11C.05Page 27ProgesteroneMain Roles

Hormones sexuelles page 27

11C.05Page 28ProgesteroneCycle Levels Graph

Hormones sexuelles page 28

11C.05Page 29ProgesteroneEndometrial Changes

Hormones sexuelles page 29

11C.05Page 30EstrogensSection Outline

Hormones sexuelles page 30

11C.05Page 31EstrogensStructure & Aromatase

Hormones sexuelles page 31

11C.05Page 32EstrogensTransport & Regulation

Hormones sexuelles page 32

11C.05Page 33EstrogensEstrogen Feedback Diagram

Hormones sexuelles page 33

11C.05Page 34EstrogensFull Cycle Overview

Hormones sexuelles page 34

11C.05Page 35EstrogensMain Roles

Hormones sexuelles page 35

11C.05Page 36EstrogensEstradiol Cycle Levels

Hormones sexuelles page 36

11C.05Page 37EstrogensEndometrial Growth & LH Peak

Hormones sexuelles page 37

11C.05Page 38EstrogensFemale Puberty Changes

Hormones sexuelles page 38

11C.05Page 39EstrogensRole in Spermatogenesis

Hormones sexuelles page 39

11C.05Page 40EstrogensCycle Summary

Hormones sexuelles page 40

11C.05Page 41AndrogensSection Outline

Hormones sexuelles page 41

11C.05Page 42AndrogensStructure & Production

Hormones sexuelles page 42

11C.05Page 43AndrogensTransport, Regulation & AR

Hormones sexuelles page 43

11C.05Page 44AndrogensHPT Axis Diagram

Hormones sexuelles page 44

11C.05Page 45AndrogensMain Roles

Hormones sexuelles page 45

11C.05Page 46AndrogensAnabolic vs Other Effects

Hormones sexuelles page 46

11C.05Page 47AndrogensFetal Sexual Differentiation

Hormones sexuelles page 47

11C.05Page 48AndrogensMale Phenotype Summary

Hormones sexuelles page 48

11C.05Page 49AndrogensBrain Imprinting

Hormones sexuelles page 49

11C.05Page 50AndrogensTesticular Descent

Hormones sexuelles page 50

11C.05Page 51AndrogensMale Secondary Characteristics

Hormones sexuelles page 51

11C.05Page 52AndrogensMale Puberty Timeline

Hormones sexuelles page 52

11C.05Page 53AndrogensOvarian Follicular Role

Hormones sexuelles page 53

11C.05Page 54AndrogensFemale Androgen Excess

Hormones sexuelles page 54

11C.05Page 55AndrogensMale Hypogonadism

Hormones sexuelles page 55

11C.05Page 56Steroid MeasurementCycle Graph Scale Caution

Hormones sexuelles page 56

11C.05Page 57Steroid MeasurementAnabolic Steroids Context

Hormones sexuelles page 57

11C.05Page 58Steroid MeasurementDosage Introduction

Hormones sexuelles page 58

11C.05Page 59Steroid MeasurementMeasurement Challenge: Concentration

Hormones sexuelles page 59

11C.05Page 60Steroid MeasurementMeasurement Challenge: Structural Similarity

Hormones sexuelles page 60

11C.05Page 61Steroid MeasurementRIA: Historical Context

Hormones sexuelles page 61

11C.05Page 62Steroid MeasurementRIA Principle

Hormones sexuelles page 62

11C.05Page 63Steroid MeasurementGC-MS Method Overview

Hormones sexuelles page 63

11C.05Page 64Steroid MeasurementGC-MS: Injection Step

Hormones sexuelles page 64

11C.05Page 65Steroid MeasurementGC-MS: Retention Time & Detection

Hormones sexuelles page 65

11C.05Page 66Steroid MeasurementGC-MS / LC-MS Summary

Hormones sexuelles page 66

11C.05Page 67Steroid MeasurementNormal Cycle Reference Values

Hormones sexuelles page 67

11C.05Page 68Steroid MeasurementFree Fraction Measurement

Hormones sexuelles page 68

11C.05Page 69Conclusions

Hormones sexuelles page 69

11C.05Page 70Abbreviations

Hormones sexuelles page 70