12.02 · Cours 2 — Immunité innée

Course 2 — Innate immunity

SMB4 Systèmes physiologiques 2 Immunologie, inflammation, transplantation · 59 pages

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Innate Immunity

1Innate Immunity 2Definitions 3Overview & Components

Physical Barriers

4Physical Barriers 5Body Surface Map 6Tight Junctions 7Epithelial Defenses by Site 8M Cells & Peyer's Patches 9M Cell Transcytosis 10Commensal Flora & Bacteriocins

Complement System

11Complement System 12Three Activation Pathways 13Classical Pathway — Cascade Detail 14Classical Pathway — IgM vs IgG Binding 15Acute-Phase Proteins: MBL & CRP 16Alternative Pathway 17Pathway Convergence & MAC Lysis 18Complement Summary

Interferons & Antiviral Immunity

19Interferons & Antiviral Immunity 20Viral Structure & Replication Cycle 21Interferon Discovery — Unprotected Cells 22Interferon Discovery — Pre-Treatment Protection 23Interferon Discovery — Soluble Factor 24Interferon Classification (Types I–III)25Viral Sensing → IFN-β Induction 26Cytoplasmic Sensors: RIG-I & MDA-5 27Autocrine & Paracrine IFN Signaling 28Antiviral State: ISGs & PKR 29Type I IFN Effects Summary

Granulocytes & Mast Cells

31Granulocytes & Mast Cells 32Hematopoietic Lineage 33Mast Cell Degranulation & IgE Cross-Linking 34Anti-Parasitic Immunity

Phagocytic System

35Phagocytic System 36Hematopoietic Lineage — Phagocyte Focus 37Neutrophil Extracellular Traps (NETs)38Phagocytosis — Introduction 39Phagocytosis — General Principles 40Opsonization by Complement 41Opsonization by Antibodies 42Phagocyte Surface Receptors 43Intracellular Killing Mechanisms 44Neutrophil Granules & ROS Production 45ROS Cascade: O₂ → HOCl 46Macrophage Phagocytosis 47NOX2 Deficiency 48Chronic Granulomatous Disease (CGD)

Toll-Like Receptors (TLRs)

49Toll-Like Receptors (TLRs)50TLR Domain Structure 51TLR Locations & PAMPs/PRRs 52TLR Ligand & Cell Reference Table 53TLR Signaling: Priming & Inflammasome Activation

54NLRP3 Inflammasome Assembly 55NLRP3 vs NLRC4 vs AIM2 56NLRP3 Signaling & GSDMD Pore Release

Inflammation — Innate to Adaptive Bridge

57Inflammation — Innate to Adaptive Bridge 58Local Inflammation → Antigen Presentation

59Lecture Summary

12.02Page 1Innate Immunity

Cours 2 — Immunité innée page 1

12.02Page 2Innate ImmunityDefinitions

Cours 2 — Immunité innée page 2

12.02Page 3Innate ImmunityOverview & Components

Cours 2 — Immunité innée page 3

12.02Page 4Innate ImmunityPhysical Barriers

Cours 2 — Immunité innée page 4

12.02Page 5Innate ImmunityPhysical BarriersBody Surface Map

Cours 2 — Immunité innée page 5

12.02Page 6Innate ImmunityPhysical BarriersTight Junctions

Cours 2 — Immunité innée page 6

12.02Page 7Innate ImmunityPhysical BarriersEpithelial Defenses by Site

Cours 2 — Immunité innée page 7

12.02Page 8Innate ImmunityPhysical BarriersM Cells & Peyer's Patches

Cours 2 — Immunité innée page 8

12.02Page 9Innate ImmunityPhysical BarriersM Cell Transcytosis

Cours 2 — Immunité innée page 9

12.02Page 10Innate ImmunityPhysical BarriersCommensal Flora & Bacteriocins

Cours 2 — Immunité innée page 10

12.02Page 11Innate ImmunityComplement System

Cours 2 — Immunité innée page 11

12.02Page 12Innate ImmunityComplement SystemThree Activation Pathways

Cours 2 — Immunité innée page 12

12.02Page 13Innate ImmunityComplement SystemClassical Pathway — Cascade Detail

Cours 2 — Immunité innée page 13

12.02Page 14Innate ImmunityComplement SystemClassical Pathway — IgM vs IgG Binding

Cours 2 — Immunité innée page 14

12.02Page 15Innate ImmunityComplement SystemAcute-Phase Proteins: MBL & CRP

Cours 2 — Immunité innée page 15

12.02Page 16Innate ImmunityComplement SystemAlternative Pathway

Cours 2 — Immunité innée page 16

12.02Page 17Innate ImmunityComplement SystemPathway Convergence & MAC Lysis

Cours 2 — Immunité innée page 17

12.02Page 18Innate ImmunityComplement SystemComplement Summary

Cours 2 — Immunité innée page 18

12.02Page 19Innate ImmunityInterferons & Antiviral Immunity

Cours 2 — Immunité innée page 19

12.02Page 20Innate ImmunityInterferons & Antiviral ImmunityViral Structure & Replication Cycle

Cours 2 — Immunité innée page 20

12.02Page 21Innate ImmunityInterferons & Antiviral ImmunityInterferon Discovery — Unprotected Cells

Cours 2 — Immunité innée page 21

12.02Page 22Innate ImmunityInterferons & Antiviral ImmunityInterferon Discovery — Pre-Treatment Protection

Cours 2 — Immunité innée page 22

12.02Page 23Innate ImmunityInterferons & Antiviral ImmunityInterferon Discovery — Soluble Factor

Cours 2 — Immunité innée page 23

12.02Page 24Innate ImmunityInterferons & Antiviral ImmunityInterferon Classification (Types I–III)

Cours 2 — Immunité innée page 24

12.02Page 25Innate ImmunityInterferons & Antiviral ImmunityViral Sensing → IFN-β Induction

Cours 2 — Immunité innée page 25

12.02Page 26Innate ImmunityInterferons & Antiviral ImmunityCytoplasmic Sensors: RIG-I & MDA-5

Cours 2 — Immunité innée page 26

12.02Page 27Innate ImmunityInterferons & Antiviral ImmunityAutocrine & Paracrine IFN Signaling

Cours 2 — Immunité innée page 27

12.02Page 28Innate ImmunityInterferons & Antiviral ImmunityAntiviral State: ISGs & PKR

Cours 2 — Immunité innée page 28

12.02Page 29Innate ImmunityInterferons & Antiviral ImmunityType I IFN Effects Summary

Cours 2 — Immunité innée page 29

12.02Page 30Innate ImmunityNK Cells

Cours 2 — Immunité innée page 30

12.02Page 31Innate ImmunityGranulocytes & Mast Cells

Cours 2 — Immunité innée page 31

12.02Page 32Innate ImmunityGranulocytes & Mast CellsHematopoietic Lineage

Cours 2 — Immunité innée page 32

12.02Page 33Innate ImmunityGranulocytes & Mast CellsMast Cell Degranulation & IgE Cross-Linking

Cours 2 — Immunité innée page 33

12.02Page 34Innate ImmunityGranulocytes & Mast CellsAnti-Parasitic Immunity

Cours 2 — Immunité innée page 34

12.02Page 35Innate ImmunityPhagocytic System

Cours 2 — Immunité innée page 35

12.02Page 36Innate ImmunityPhagocytic SystemHematopoietic Lineage — Phagocyte Focus

Cours 2 — Immunité innée page 36

12.02Page 37Innate ImmunityPhagocytic SystemNeutrophil Extracellular Traps (NETs)

Cours 2 — Immunité innée page 37

12.02Page 38Innate ImmunityPhagocytic SystemPhagocytosis — Introduction

Cours 2 — Immunité innée page 38

12.02Page 39Innate ImmunityPhagocytic SystemPhagocytosis — General Principles

Cours 2 — Immunité innée page 39

12.02Page 40Innate ImmunityPhagocytic SystemOpsonization by Complement

Cours 2 — Immunité innée page 40

12.02Page 41Innate ImmunityPhagocytic SystemOpsonization by Antibodies

Cours 2 — Immunité innée page 41

12.02Page 42Innate ImmunityPhagocytic SystemPhagocyte Surface Receptors

Cours 2 — Immunité innée page 42

12.02Page 43Innate ImmunityPhagocytic SystemIntracellular Killing Mechanisms

Cours 2 — Immunité innée page 43

12.02Page 44Innate ImmunityPhagocytic SystemNeutrophil Granules & ROS Production

Cours 2 — Immunité innée page 44

12.02Page 45Innate ImmunityPhagocytic SystemROS Cascade: O₂ → HOCl

Cours 2 — Immunité innée page 45

12.02Page 46Innate ImmunityPhagocytic SystemMacrophage Phagocytosis

Cours 2 — Immunité innée page 46

12.02Page 47Innate ImmunityPhagocytic SystemNOX2 Deficiency

Cours 2 — Immunité innée page 47

12.02Page 48Innate ImmunityPhagocytic SystemChronic Granulomatous Disease (CGD)

Cours 2 — Immunité innée page 48

12.02Page 49Innate ImmunityToll-Like Receptors (TLRs)

Cours 2 — Immunité innée page 49

12.02Page 50Innate ImmunityToll-Like Receptors (TLRs)TLR Domain Structure

Cours 2 — Immunité innée page 50

12.02Page 51Innate ImmunityToll-Like Receptors (TLRs)TLR Locations & PAMPs/PRRs

Cours 2 — Immunité innée page 51

12.02Page 52Innate ImmunityToll-Like Receptors (TLRs)TLR Ligand & Cell Reference Table

Cours 2 — Immunité innée page 52

12.02Page 53Innate ImmunityToll-Like Receptors (TLRs)TLR Signaling: Priming & Inflammasome Activation

Cours 2 — Immunité innée page 53

12.02Page 54Innate ImmunityInflammasomesNLRP3 Inflammasome Assembly

Cours 2 — Immunité innée page 54

12.02Page 55Innate ImmunityInflammasomesNLRP3 vs NLRC4 vs AIM2

Cours 2 — Immunité innée page 55

12.02Page 56Innate ImmunityInflammasomesNLRP3 Signaling & GSDMD Pore Release

Cours 2 — Immunité innée page 56

12.02Page 57Innate ImmunityInflammation — Innate to Adaptive Bridge

Cours 2 — Immunité innée page 57

12.02Page 58Innate ImmunityInflammation — Innate to Adaptive BridgeLocal Inflammation → Antigen Presentation

Cours 2 — Immunité innée page 58

12.02Page 59Innate ImmunityLecture Summary

Cours 2 — Immunité innée page 59