12.06 · Immunité adaptative — lymphocytes B

Adaptive immunity — B lymphocytes

SMB4 Systèmes physiologiques 2 Immunologie, inflammation, transplantation · 34 pages

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Adaptive Immunity — B Lymphocytes

1Adaptive Immunity — B Lymphocytes 2Course Overview 3Antibody Structure 4Antibody Isotypes

BCR Rearrangement

5B-Cell Development in Bone Marrow 6VDJ Recombination & Combinatorial Diversity 7BCR Diversity Quantification 8IgM and IgD Co-Expression

B-Cell Activation

9Overview in Secondary Lymphoid Organs 10Antigen Binding — Epitopes 11Signal 1 — BCR Cross-Linking 12Signal 2 — T-Cell Help in Lymph Node 13Signal 2 — CD40L and Cytokines 14Early IgM Secretion by Plasma Cells

Germinal Center

15Germinal Center Initiation 16Germinal Center Structure 17AID — Affinity Maturation & Isotype Switching 18Isotype Switching Mechanism 19Cytokine Control of Isotype Switching 20Somatic Hypermutation — CDR Regions 21Affinity Maturation — Selection by FDC 22Transition

Antibody Distribution & Transport

23Isotype Distribution in the Body 24IgG Active Transport via FcRn 25Dimeric IgA Transport to Mucosa 26Neonatal Vulnerability Period

Antibody Functions

27Neutralization of Viruses 28Neutralization of Bacteria 29Neutralization of Toxins 30Complement Activation — Classical Pathway 31Opsonization 32ADCC by NK Cells 33IgE Response Against Parasites 34Isotype Function Summary Table

12.06Page 1Adaptive Immunity — B Lymphocytes

Immunité adaptative — lymphocytes B page 1

12.06Page 2Adaptive Immunity — B LymphocytesCourse Overview

Immunité adaptative — lymphocytes B page 2

12.06Page 3Adaptive Immunity — B LymphocytesAntibody Structure

Immunité adaptative — lymphocytes B page 3

12.06Page 4Adaptive Immunity — B LymphocytesAntibody Isotypes

Immunité adaptative — lymphocytes B page 4

12.06Page 5Adaptive Immunity — B LymphocytesBCR RearrangementB-Cell Development in Bone Marrow

Immunité adaptative — lymphocytes B page 5

12.06Page 6Adaptive Immunity — B LymphocytesBCR RearrangementVDJ Recombination & Combinatorial Diversity

Immunité adaptative — lymphocytes B page 6

12.06Page 7Adaptive Immunity — B LymphocytesBCR RearrangementBCR Diversity Quantification

Immunité adaptative — lymphocytes B page 7

12.06Page 8Adaptive Immunity — B LymphocytesBCR RearrangementIgM and IgD Co-Expression

Immunité adaptative — lymphocytes B page 8

12.06Page 9Adaptive Immunity — B LymphocytesB-Cell ActivationOverview in Secondary Lymphoid Organs

Immunité adaptative — lymphocytes B page 9

12.06Page 10Adaptive Immunity — B LymphocytesB-Cell ActivationAntigen Binding — Epitopes

Immunité adaptative — lymphocytes B page 10

12.06Page 11Adaptive Immunity — B LymphocytesB-Cell ActivationSignal 1 — BCR Cross-Linking

Immunité adaptative — lymphocytes B page 11

12.06Page 12Adaptive Immunity — B LymphocytesB-Cell ActivationSignal 2 — T-Cell Help in Lymph Node

Immunité adaptative — lymphocytes B page 12

12.06Page 13Adaptive Immunity — B LymphocytesB-Cell ActivationSignal 2 — CD40L and Cytokines

Immunité adaptative — lymphocytes B page 13

12.06Page 14Adaptive Immunity — B LymphocytesB-Cell ActivationEarly IgM Secretion by Plasma Cells

Immunité adaptative — lymphocytes B page 14

12.06Page 15Adaptive Immunity — B LymphocytesGerminal CenterGerminal Center Initiation

Immunité adaptative — lymphocytes B page 15

12.06Page 16Adaptive Immunity — B LymphocytesGerminal CenterGerminal Center Structure

Immunité adaptative — lymphocytes B page 16

12.06Page 17Adaptive Immunity — B LymphocytesGerminal CenterAID — Affinity Maturation & Isotype Switching

Immunité adaptative — lymphocytes B page 17

12.06Page 18Adaptive Immunity — B LymphocytesGerminal CenterIsotype Switching Mechanism

Immunité adaptative — lymphocytes B page 18

12.06Page 19Adaptive Immunity — B LymphocytesGerminal CenterCytokine Control of Isotype Switching

Immunité adaptative — lymphocytes B page 19

12.06Page 20Adaptive Immunity — B LymphocytesGerminal CenterSomatic Hypermutation — CDR Regions

Immunité adaptative — lymphocytes B page 20

12.06Page 21Adaptive Immunity — B LymphocytesGerminal CenterAffinity Maturation — Selection by FDC

Immunité adaptative — lymphocytes B page 21

12.06Page 22Adaptive Immunity — B LymphocytesGerminal CenterTransition

Immunité adaptative — lymphocytes B page 22

12.06Page 23Adaptive Immunity — B LymphocytesAntibody Distribution & TransportIsotype Distribution in the Body

Immunité adaptative — lymphocytes B page 23

12.06Page 24Adaptive Immunity — B LymphocytesAntibody Distribution & TransportIgG Active Transport via FcRn

Immunité adaptative — lymphocytes B page 24

12.06Page 25Adaptive Immunity — B LymphocytesAntibody Distribution & TransportDimeric IgA Transport to Mucosa

Immunité adaptative — lymphocytes B page 25

12.06Page 26Adaptive Immunity — B LymphocytesAntibody Distribution & TransportNeonatal Vulnerability Period

Immunité adaptative — lymphocytes B page 26

12.06Page 27Adaptive Immunity — B LymphocytesAntibody FunctionsNeutralization of Viruses

Immunité adaptative — lymphocytes B page 27

12.06Page 28Adaptive Immunity — B LymphocytesAntibody FunctionsNeutralization of Bacteria

Immunité adaptative — lymphocytes B page 28

12.06Page 29Adaptive Immunity — B LymphocytesAntibody FunctionsNeutralization of Toxins

Immunité adaptative — lymphocytes B page 29

12.06Page 30Adaptive Immunity — B LymphocytesAntibody FunctionsComplement Activation — Classical Pathway

Immunité adaptative — lymphocytes B page 30

12.06Page 31Adaptive Immunity — B LymphocytesAntibody FunctionsOpsonization

Immunité adaptative — lymphocytes B page 31

12.06Page 32Adaptive Immunity — B LymphocytesAntibody FunctionsADCC by NK Cells

Immunité adaptative — lymphocytes B page 32

12.06Page 33Adaptive Immunity — B LymphocytesAntibody FunctionsIgE Response Against Parasites

Immunité adaptative — lymphocytes B page 33

12.06Page 34Adaptive Immunity — B LymphocytesAntibody FunctionsIsotype Function Summary Table

Immunité adaptative — lymphocytes B page 34