12.09 · Extravasation leucocytaire

Leukocyte extravasation

SMB4 Systèmes physiologiques 2 Immunologie, inflammation, transplantation · 45 pages

All pagesPage view Open original PDF

All pages overview. Scroll the whole file, jump by section, or jump directly to a page.

← Previous file → Next file

Lymphocyte Circulation & Extravasation

1Lymphocyte Circulation & Extravasation

Leukocyte Adhesion Cascade

2Lymphocyte Recirculation 3Cascade Overview 4Rolling → Activation → Adhesion → Extravasation 5Detailed Eight-Step Cascade 6Cascade with Vessel Wall Layers 7Live Imaging of Extravasation 8Molecules Involved in the Process

9Rolling in Arterioles vs Venules 10Rolling in the Full Cascade 11Selectins & Selectin Ligands 12Selectin Family: L, E, P 13Selectin Modular Structure 14Selectin Ligands: Sialyl Lewis X 15L-Selectin Expression Profile 16Selectin Functions: Homeostasis vs Inflammation 17Why Do Leukocytes Roll?

18Ca²⁺ Activation Signal 19Chemokines & Signaling Molecules 20Chemokines in the Cascade Summary

21Integrin Structure: α and β Subunits 22Integrin Activation: Low → High Affinity

23Chemokine Signaling via GPCRs 24Chemokine Receptor–Ligand Map 25Chemokine Structural Classes: C, CC, CXC, CX₃C

26Live Imaging of Leukocyte Adhesion 27Integrins in the Cascade Diagram 28Cascade Summary with Integrins 29Key Integrin Heterodimers: LFA-1, α4β7, VLA-4 30Integrin Ligands: ICAM, VCAM, MAdCAM

Tissue Addressing

31Integrin Addresses by Tissue 32Chemokine Addresses by Tissue 33One Door, Two Locks

Transmigration / Extravasation

34Extravasation Video Introduction 35Full Cascade with Junction Proteins 36Four-Step Summary with Transmigration 37Endothelial Cell Junctions 38Junction Proteins in Transmigration

39Simplified Cascade Recap 40Detailed Eight-Step Recap 41Four Steps with Molecule Classes

Key Messages to Remember

42Key Messages to Remember 43Four Adhesion Molecule Types 44Chemokine Receptor–Ligand Map 45One Door, Two Locks Recap

12.09Page 1Lymphocyte Circulation & Extravasation

Extravasation leucocytaire page 1

12.09Page 2Leukocyte Adhesion CascadeLymphocyte Recirculation

Extravasation leucocytaire page 2

12.09Page 3Leukocyte Adhesion CascadeCascade Overview

Extravasation leucocytaire page 3

12.09Page 4Leukocyte Adhesion CascadeRolling → Activation → Adhesion → Extravasation

Extravasation leucocytaire page 4

12.09Page 5Leukocyte Adhesion CascadeDetailed Eight-Step Cascade

Extravasation leucocytaire page 5

12.09Page 6Leukocyte Adhesion CascadeCascade with Vessel Wall Layers

Extravasation leucocytaire page 6

12.09Page 7Leukocyte Adhesion CascadeLive Imaging of Extravasation

Extravasation leucocytaire page 7

12.09Page 8Leukocyte Adhesion CascadeMolecules Involved in the Process

Extravasation leucocytaire page 8

12.09Page 9Leukocyte Adhesion CascadeRollingRolling in Arterioles vs Venules

Extravasation leucocytaire page 9

12.09Page 10Leukocyte Adhesion CascadeRollingRolling in the Full Cascade

Extravasation leucocytaire page 10

12.09Page 11Leukocyte Adhesion CascadeRollingSelectins & Selectin Ligands

Extravasation leucocytaire page 11

12.09Page 12Leukocyte Adhesion CascadeRollingSelectin Family: L, E, P

Extravasation leucocytaire page 12

12.09Page 13Leukocyte Adhesion CascadeRollingSelectin Modular Structure

Extravasation leucocytaire page 13

12.09Page 14Leukocyte Adhesion CascadeRollingSelectin Ligands: Sialyl Lewis X

Extravasation leucocytaire page 14

12.09Page 15Leukocyte Adhesion CascadeRollingL-Selectin Expression Profile

Extravasation leucocytaire page 15

12.09Page 16Leukocyte Adhesion CascadeRollingSelectin Functions: Homeostasis vs Inflammation

Extravasation leucocytaire page 16

12.09Page 17Leukocyte Adhesion CascadeRollingWhy Do Leukocytes Roll?

Extravasation leucocytaire page 17

12.09Page 18Leukocyte Adhesion CascadeActivationCa²⁺ Activation Signal

Extravasation leucocytaire page 18

12.09Page 19Leukocyte Adhesion CascadeActivationChemokines & Signaling Molecules

Extravasation leucocytaire page 19

12.09Page 20Leukocyte Adhesion CascadeActivationChemokines in the Cascade Summary

Extravasation leucocytaire page 20

12.09Page 21Leukocyte Adhesion CascadeAdhesionIntegrin Structure: α and β Subunits

Extravasation leucocytaire page 21

12.09Page 22Leukocyte Adhesion CascadeAdhesionIntegrin Activation: Low → High Affinity

Extravasation leucocytaire page 22

12.09Page 23Leukocyte Adhesion CascadeActivationChemokine Signaling via GPCRs

Extravasation leucocytaire page 23

12.09Page 24Leukocyte Adhesion CascadeActivationChemokine Receptor–Ligand Map

Extravasation leucocytaire page 24

12.09Page 25Leukocyte Adhesion CascadeActivationChemokine Structural Classes: C, CC, CXC, CX₃C

Extravasation leucocytaire page 25

12.09Page 26Leukocyte Adhesion CascadeAdhesionLive Imaging of Leukocyte Adhesion

Extravasation leucocytaire page 26

12.09Page 27Leukocyte Adhesion CascadeAdhesionIntegrins in the Cascade Diagram

Extravasation leucocytaire page 27

12.09Page 28Leukocyte Adhesion CascadeAdhesionCascade Summary with Integrins

Extravasation leucocytaire page 28

12.09Page 29Leukocyte Adhesion CascadeAdhesionKey Integrin Heterodimers: LFA-1, α4β7, VLA-4

Extravasation leucocytaire page 29

12.09Page 30Leukocyte Adhesion CascadeAdhesionIntegrin Ligands: ICAM, VCAM, MAdCAM

Extravasation leucocytaire page 30

12.09Page 31Leukocyte Adhesion CascadeTissue AddressingIntegrin Addresses by Tissue

Extravasation leucocytaire page 31

12.09Page 32Leukocyte Adhesion CascadeTissue AddressingChemokine Addresses by Tissue

Extravasation leucocytaire page 32

12.09Page 33Leukocyte Adhesion CascadeTissue AddressingOne Door, Two Locks

Extravasation leucocytaire page 33

12.09Page 34Leukocyte Adhesion CascadeTransmigration / ExtravasationExtravasation Video Introduction

Extravasation leucocytaire page 34

12.09Page 35Leukocyte Adhesion CascadeTransmigration / ExtravasationFull Cascade with Junction Proteins

Extravasation leucocytaire page 35

12.09Page 36Leukocyte Adhesion CascadeTransmigration / ExtravasationFour-Step Summary with Transmigration

Extravasation leucocytaire page 36

12.09Page 37Leukocyte Adhesion CascadeTransmigration / ExtravasationEndothelial Cell Junctions

Extravasation leucocytaire page 37

12.09Page 38Leukocyte Adhesion CascadeTransmigration / ExtravasationJunction Proteins in Transmigration

Extravasation leucocytaire page 38

12.09Page 39Leukocyte Adhesion CascadeSummarySimplified Cascade Recap

Extravasation leucocytaire page 39

12.09Page 40Leukocyte Adhesion CascadeSummaryDetailed Eight-Step Recap

Extravasation leucocytaire page 40

12.09Page 41Leukocyte Adhesion CascadeSummaryFour Steps with Molecule Classes

Extravasation leucocytaire page 41

12.09Page 42Leukocyte Adhesion CascadeKey Messages to Remember

Extravasation leucocytaire page 42

12.09Page 43Leukocyte Adhesion CascadeKey Messages to RememberFour Adhesion Molecule Types

Extravasation leucocytaire page 43

12.09Page 44Leukocyte Adhesion CascadeKey Messages to RememberChemokine Receptor–Ligand Map

Extravasation leucocytaire page 44

12.09Page 45Leukocyte Adhesion CascadeKey Messages to RememberOne Door, Two Locks Recap

Extravasation leucocytaire page 45