12.08 · Mécanismes de l’inflammation

Mechanisms of inflammation

SMB4 Systèmes physiologiques 2 Immunologie, inflammation, transplantation · 43 pages

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Mechanisms of inflammation

Mechanisms of Inflammation

1Mechanisms of Inflammation 2Lecture Outline

3Gout Attack 4Ankle Sprain 5Infectious Pneumonia

Definition and Purpose

6Definition of Acute Inflammation 7Historical Perspective 8Five Cardinal Signs 9Two Main Functions 10Causes and Homeostasis Goal 11Exogenous and Endogenous Triggers

Three Stages of Acute Inflammation

12Overview of Three Stages 13Stage 1: Arteriolar Dilation 14Stage 2: Increased Permeability 15Stage 2: Endothelial Barrier Change 16Stage 3: Leukocyte Extravasation 17Macrophages: M1 vs M2 18Neutrophil Adhesion and Transmigration

Cellular Mediators

19Cell Types Overview Table

Three Stages of Acute Inflammation

20Summary of Three Stages

Chemical Mediators

21Mast Cell and Histamine 22Histamine Receptors H1-H4 23Mast Cell: Prostaglandins and Leukotrienes 24Lipid Mediator Pathways 25Mast Cell: AGEPC / PAF 26Platelet Serotonin 27Plasma Mediators 28Complement System Pathways 29Cytokines: Definition 30Cytokine Signaling Modes 31Six Cytokine Families 32Cytokine Mechanism of Action

Local and Systemic Inflammation

33Pro-inflammatory Cytokines: Local 34Pro-inflammatory Cytokines: Systemic 35Fever as Protective Response

Resolution or Chronic Inflammation

36Resolution: Three Phases 37Cells in Resolution 38ILC2 and Inflammation Resolution 39Chronic Inflammation: Definition

Therapeutic Targets

40NSAIDs: COX Inhibition 41Glucocorticoids 42Biologic Agents: TNF/IL-1/IL-6 Blockade

12.08Page 1Mechanisms of Inflammation

Mécanismes de l’inflammation page 1

12.08Page 2Mechanisms of InflammationLecture Outline

Mécanismes de l’inflammation page 2

12.08Page 3Clinical CasesGout Attack

Mécanismes de l’inflammation page 3

12.08Page 4Clinical CasesAnkle Sprain

Mécanismes de l’inflammation page 4

12.08Page 5Clinical CasesInfectious Pneumonia

Mécanismes de l’inflammation page 5

12.08Page 6Definition and PurposeDefinition of Acute Inflammation

Mécanismes de l’inflammation page 6

12.08Page 7Definition and PurposeHistorical Perspective

Mécanismes de l’inflammation page 7

12.08Page 8Definition and PurposeFive Cardinal Signs

Mécanismes de l’inflammation page 8

12.08Page 9Definition and PurposeTwo Main Functions

Mécanismes de l’inflammation page 9

12.08Page 10Definition and PurposeCauses and Homeostasis Goal

Mécanismes de l’inflammation page 10

12.08Page 11Definition and PurposeExogenous and Endogenous Triggers

Mécanismes de l’inflammation page 11

12.08Page 12Three Stages of Acute InflammationOverview of Three Stages

Mécanismes de l’inflammation page 12

12.08Page 13Three Stages of Acute InflammationStage 1: Arteriolar Dilation

Mécanismes de l’inflammation page 13

12.08Page 14Three Stages of Acute InflammationStage 2: Increased Permeability

Mécanismes de l’inflammation page 14

12.08Page 15Three Stages of Acute InflammationStage 2: Endothelial Barrier Change

Mécanismes de l’inflammation page 15

12.08Page 16Three Stages of Acute InflammationStage 3: Leukocyte Extravasation

Mécanismes de l’inflammation page 16

12.08Page 17Three Stages of Acute InflammationMacrophages: M1 vs M2

Mécanismes de l’inflammation page 17

12.08Page 18Three Stages of Acute InflammationNeutrophil Adhesion and Transmigration

Mécanismes de l’inflammation page 18

12.08Page 19Cellular MediatorsCell Types Overview Table

Mécanismes de l’inflammation page 19

12.08Page 20Three Stages of Acute InflammationSummary of Three Stages

Mécanismes de l’inflammation page 20

12.08Page 21Chemical MediatorsMast Cell and Histamine

Mécanismes de l’inflammation page 21

12.08Page 22Chemical MediatorsHistamine Receptors H1-H4

Mécanismes de l’inflammation page 22

12.08Page 23Chemical MediatorsMast Cell: Prostaglandins and Leukotrienes

Mécanismes de l’inflammation page 23

12.08Page 24Chemical MediatorsLipid Mediator Pathways

Mécanismes de l’inflammation page 24

12.08Page 25Chemical MediatorsMast Cell: AGEPC / PAF

Mécanismes de l’inflammation page 25

12.08Page 26Chemical MediatorsPlatelet Serotonin

Mécanismes de l’inflammation page 26

12.08Page 27Chemical MediatorsPlasma Mediators

Mécanismes de l’inflammation page 27

12.08Page 28Chemical MediatorsComplement System Pathways

Mécanismes de l’inflammation page 28

12.08Page 29Chemical MediatorsCytokines: Definition

Mécanismes de l’inflammation page 29

12.08Page 30Chemical MediatorsCytokine Signaling Modes

Mécanismes de l’inflammation page 30

12.08Page 31Chemical MediatorsSix Cytokine Families

Mécanismes de l’inflammation page 31

12.08Page 32Chemical MediatorsCytokine Mechanism of Action

Mécanismes de l’inflammation page 32

12.08Page 33Local and Systemic InflammationPro-inflammatory Cytokines: Local

Mécanismes de l’inflammation page 33

12.08Page 34Local and Systemic InflammationPro-inflammatory Cytokines: Systemic

Mécanismes de l’inflammation page 34

12.08Page 35Local and Systemic InflammationFever as Protective Response

Mécanismes de l’inflammation page 35

12.08Page 36Resolution or Chronic InflammationResolution: Three Phases

Mécanismes de l’inflammation page 36

12.08Page 37Resolution or Chronic InflammationCells in Resolution

Mécanismes de l’inflammation page 37

12.08Page 38Resolution or Chronic InflammationILC2 and Inflammation Resolution

Mécanismes de l’inflammation page 38

12.08Page 39Resolution or Chronic InflammationChronic Inflammation: Definition

Mécanismes de l’inflammation page 39

12.08Page 40Therapeutic TargetsNSAIDs: COX Inhibition

Mécanismes de l’inflammation page 40

12.08Page 41Therapeutic TargetsGlucocorticoids

Mécanismes de l’inflammation page 41

12.08Page 42Therapeutic TargetsBiologic Agents: TNF/IL-1/IL-6 Blockade

Mécanismes de l’inflammation page 42

12.08Page 43Closing

Mécanismes de l’inflammation page 43