14.07 · Cours 2 — Métabolisme des acides gras

Course 2 — Fatty acid metabolism

Balance énergétique et lipides · 61 pages

All pagesPage view Open original PDF

All pages overview. Scroll the whole file, jump by section, or jump directly to a page.

← Previous file → Next file

Fatty Acid Metabolism

1Fatty Acid Metabolism 2Course Outline

β-Oxidation (Catabolism)

3Overview 4Metabolic Context 5Saturated FA Pathway & Carnitine Shuttle 6Carnitine Shuttle for Long-Chain FA 7Carnitine Sources 8Metabolic Context 9Four-Step Cycle Detail 10C14:0 Worked Example 11Key Summary Points 12Special Cases: Unsaturated & Odd-Chain FA 13Three Stages to ATP 14Carnitine Supplements: Medicine or Quackery?15Carnitine as Transport Helper 16Fate of Acetyl-CoA 17Peroxisomal β-Oxidation

18ATP Yield of C16 β-Oxidation 19Citric Acid Cycle: 12 ATP per Acetyl-CoA 20Glucose Catabolism Comparison 21Energy Expenditure Components 22Respiratory Quotient (RQ)23Glucose Electron Balance 24Catabolism–RQ Relationship 25Palmitate Electron Balance & RQ 26Stearate Electron Balance & RQ

Fatty Acid Synthesis (Anabolism)

27Overview: Abundance & Insulin 28Metabolic Context 29Three Main Mechanisms 30Cytosolic Synthesis: Substrates & Citrate Shuttle 31Adipose Tissue Distribution 32Citrate Shuttle Mechanism 33Citrate Shuttle & NADPH Generation 34NADPH Sources 35Metabolic Connections

36Step 1: ACC — Malonyl-CoA Formation 37Malonyl-CoA Production Detail

Fatty Acid Synthesis (Anabolism)

38Metabolic Context

39Step 2: FAS Cycle Overview 40FAS 3D Structure 41Cycle Initiation (Overview)42Cycle Initiation (Detailed)43Cycle Initiation (Continued)44Full Cycle with All Six Steps 45Seven Rounds on FAS (Part 1)46Seven Rounds on FAS (Part 2)47Seven Rounds on FAS (Chemical Detail)48Palmitate Release by Thioesterase 49ACC Biotin Mechanism 50Step A: Condensation 51Step B: First Reduction (NADPH)52Step C: Dehydration 53Step D: Second Reduction (NADPH)54Cycle Summary: C2 to C16 55Palmitate Formation Summary

Fatty Acid Synthesis (Anabolism)

56Malonyl-CoA Inhibits Carnitine Shuttle

57Complete Pathway Diagram

Fatty Acid Synthesis (Anabolism)

58Elongation & Desaturation 59Mitochondrial Elongation Detail

60Adipose Tissue Regulation Overview 61ACC Regulation Signals

14.07Page 1Fatty Acid Metabolism

Cours 2 — Métabolisme des acides gras page 1

14.07Page 2Fatty Acid MetabolismCourse Outline

Cours 2 — Métabolisme des acides gras page 2

14.07Page 3Fatty Acid Metabolismβ-Oxidation (Catabolism)Overview

Cours 2 — Métabolisme des acides gras page 3

14.07Page 4Fatty Acid Metabolismβ-Oxidation (Catabolism)Metabolic Context

Cours 2 — Métabolisme des acides gras page 4

14.07Page 5Fatty Acid Metabolismβ-Oxidation (Catabolism)Saturated FA Pathway & Carnitine Shuttle

Cours 2 — Métabolisme des acides gras page 5

14.07Page 6Fatty Acid Metabolismβ-Oxidation (Catabolism)Carnitine Shuttle for Long-Chain FA

Cours 2 — Métabolisme des acides gras page 6

14.07Page 7Fatty Acid Metabolismβ-Oxidation (Catabolism)Carnitine Sources

Cours 2 — Métabolisme des acides gras page 7

14.07Page 8Fatty Acid Metabolismβ-Oxidation (Catabolism)Metabolic Context

Cours 2 — Métabolisme des acides gras page 8

14.07Page 9Fatty Acid Metabolismβ-Oxidation (Catabolism)Four-Step Cycle Detail

Cours 2 — Métabolisme des acides gras page 9

14.07Page 10Fatty Acid Metabolismβ-Oxidation (Catabolism)C14:0 Worked Example

Cours 2 — Métabolisme des acides gras page 10

14.07Page 11Fatty Acid Metabolismβ-Oxidation (Catabolism)Key Summary Points

Cours 2 — Métabolisme des acides gras page 11

14.07Page 12Fatty Acid Metabolismβ-Oxidation (Catabolism)Special Cases: Unsaturated & Odd-Chain FA

Cours 2 — Métabolisme des acides gras page 12

14.07Page 13Fatty Acid Metabolismβ-Oxidation (Catabolism)Three Stages to ATP

Cours 2 — Métabolisme des acides gras page 13

14.07Page 14Fatty Acid Metabolismβ-Oxidation (Catabolism)Carnitine Supplements: Medicine or Quackery?

Cours 2 — Métabolisme des acides gras page 14

14.07Page 15Fatty Acid Metabolismβ-Oxidation (Catabolism)Carnitine as Transport Helper

Cours 2 — Métabolisme des acides gras page 15

14.07Page 16Fatty Acid Metabolismβ-Oxidation (Catabolism)Fate of Acetyl-CoA

Cours 2 — Métabolisme des acides gras page 16

14.07Page 17Fatty Acid Metabolismβ-Oxidation (Catabolism)Peroxisomal β-Oxidation

Cours 2 — Métabolisme des acides gras page 17

14.07Page 18Fatty Acid MetabolismEnergy BalanceATP Yield of C16 β-Oxidation

Cours 2 — Métabolisme des acides gras page 18

14.07Page 19Fatty Acid MetabolismEnergy BalanceCitric Acid Cycle: 12 ATP per Acetyl-CoA

Cours 2 — Métabolisme des acides gras page 19

14.07Page 20Fatty Acid MetabolismEnergy BalanceGlucose Catabolism Comparison

Cours 2 — Métabolisme des acides gras page 20

14.07Page 21Fatty Acid MetabolismEnergy BalanceEnergy Expenditure Components

Cours 2 — Métabolisme des acides gras page 21

14.07Page 22Fatty Acid MetabolismEnergy BalanceRespiratory Quotient (RQ)

Cours 2 — Métabolisme des acides gras page 22

14.07Page 23Fatty Acid MetabolismEnergy BalanceGlucose Electron Balance

Cours 2 — Métabolisme des acides gras page 23

14.07Page 24Fatty Acid MetabolismEnergy BalanceCatabolism–RQ Relationship

Cours 2 — Métabolisme des acides gras page 24

14.07Page 25Fatty Acid MetabolismEnergy BalancePalmitate Electron Balance & RQ

Cours 2 — Métabolisme des acides gras page 25

14.07Page 26Fatty Acid MetabolismEnergy BalanceStearate Electron Balance & RQ

Cours 2 — Métabolisme des acides gras page 26

14.07Page 27Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Overview: Abundance & Insulin

Cours 2 — Métabolisme des acides gras page 27

14.07Page 28Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Metabolic Context

Cours 2 — Métabolisme des acides gras page 28

14.07Page 29Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Three Main Mechanisms

Cours 2 — Métabolisme des acides gras page 29

14.07Page 30Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Cytosolic Synthesis: Substrates & Citrate Shuttle

Cours 2 — Métabolisme des acides gras page 30

14.07Page 31Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Adipose Tissue Distribution

Cours 2 — Métabolisme des acides gras page 31

14.07Page 32Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Citrate Shuttle Mechanism

Cours 2 — Métabolisme des acides gras page 32

14.07Page 33Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Citrate Shuttle & NADPH Generation

Cours 2 — Métabolisme des acides gras page 33

14.07Page 34Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)NADPH Sources

Cours 2 — Métabolisme des acides gras page 34

14.07Page 35Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Metabolic Connections

Cours 2 — Métabolisme des acides gras page 35

14.07Page 36Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsStep 1: ACC — Malonyl-CoA Formation

Cours 2 — Métabolisme des acides gras page 36

14.07Page 37Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsMalonyl-CoA Production Detail

Cours 2 — Métabolisme des acides gras page 37

14.07Page 38Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Metabolic Context

Cours 2 — Métabolisme des acides gras page 38

14.07Page 39Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsStep 2: FAS Cycle Overview

Cours 2 — Métabolisme des acides gras page 39

14.07Page 40Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsFAS 3D Structure

Cours 2 — Métabolisme des acides gras page 40

14.07Page 41Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsCycle Initiation (Overview)

Cours 2 — Métabolisme des acides gras page 41

14.07Page 42Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsCycle Initiation (Detailed)

Cours 2 — Métabolisme des acides gras page 42

14.07Page 43Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsCycle Initiation (Continued)

Cours 2 — Métabolisme des acides gras page 43

14.07Page 44Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsFull Cycle with All Six Steps

Cours 2 — Métabolisme des acides gras page 44

14.07Page 45Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsSeven Rounds on FAS (Part 1)

Cours 2 — Métabolisme des acides gras page 45

14.07Page 46Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsSeven Rounds on FAS (Part 2)

Cours 2 — Métabolisme des acides gras page 46

14.07Page 47Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsSeven Rounds on FAS (Chemical Detail)

Cours 2 — Métabolisme des acides gras page 47

14.07Page 48Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsPalmitate Release by Thioesterase

Cours 2 — Métabolisme des acides gras page 48

14.07Page 49Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsACC Biotin Mechanism

Cours 2 — Métabolisme des acides gras page 49

14.07Page 50Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsStep A: Condensation

Cours 2 — Métabolisme des acides gras page 50

14.07Page 51Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsStep B: First Reduction (NADPH)

Cours 2 — Métabolisme des acides gras page 51

14.07Page 52Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsStep C: Dehydration

Cours 2 — Métabolisme des acides gras page 52

14.07Page 53Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsStep D: Second Reduction (NADPH)

Cours 2 — Métabolisme des acides gras page 53

14.07Page 54Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsCycle Summary: C2 to C16

Cours 2 — Métabolisme des acides gras page 54

14.07Page 55Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsPalmitate Formation Summary

Cours 2 — Métabolisme des acides gras page 55

14.07Page 56Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Malonyl-CoA Inhibits Carnitine Shuttle

Cours 2 — Métabolisme des acides gras page 56

14.07Page 57Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)FAS ReactionsComplete Pathway Diagram

Cours 2 — Métabolisme des acides gras page 57

14.07Page 58Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Elongation & Desaturation

Cours 2 — Métabolisme des acides gras page 58

14.07Page 59Fatty Acid MetabolismFatty Acid Synthesis (Anabolism)Mitochondrial Elongation Detail

Cours 2 — Métabolisme des acides gras page 59

14.07Page 60Fatty Acid MetabolismRegulationAdipose Tissue Regulation Overview

Cours 2 — Métabolisme des acides gras page 60

14.07Page 61Fatty Acid MetabolismRegulationACC Regulation Signals

Cours 2 — Métabolisme des acides gras page 61